The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study DOI Open Access
Andrew Williamson, Alison E Lim,

FR Green

et al.

Head & Neck, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Background To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) describe survival outcomes. Methods Post hoc subgroup analysis a retrospective national observational cohort was conducted. All patients with rHNSCC who received definitive treatment decision between September 1, 2021 November 30, were included. Survival stratified according to subsite, primary versus disease, surgical nonsurgical treatment. Results Data from 202 derived 1488 submitted by 50 UK centers. Median age 66 years (IQR 58–74), 142 (70.3%) male. The most common recurrence subsites oropharynx (20.5%), oral cavity (19.5%), larynx (16.4%), hypopharynx (14.9%). Ninety‐three (48.4%) managed curatively. Surgery for laryngeal (59.4%), (60.5%), hypopharyngeal (44.8%), oropharyngeal (37.5%) cancers. Two‐year overall (OS), disease‐free (DFS), disease‐specific (DSS), local free (LRFS) 41.1%, 39.1%, 42.2%, 39.3%, respectively. treated surgery had improved OS ( p = 0.0005), DFS 0.012), DSS 0.0003), LRFS 0.007), over treatments. Compared cancers, presents more advanced T stage < 0.001) distant metastasis 0.001), receives less curative has worse outcomes (all 0.001). On multivariate analysis, salvage surgery, radiotherapy, p16 status independent prognostic factors all Conclusions Recurrent HNSCC is associated high rates incurable disease than remains in rHNSCC, however future studies are necessary improve patient selection optimize following

Language: Английский

Shorter Time to Biopsy of Patients with Head and Neck Squamous Cell Carcinoma During the COVID-19 Pandemic in Hungary DOI Open Access
Éva Szabó, Eszter Kopjár,

László Rumi

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 360 - 360

Published: Jan. 23, 2025

Background/objectives: The goal of this investigation was to compare the time biopsy (TBI) and treatment (TTI) for head neck squamous cell carcinoma (HNSCC) patients before during COVID-19 pandemic examine effect demographic clinical characteristics on these intervals. Methods: Our retrospective study at a large regional Hungarian cancer center analyzed data from aged 18 or older diagnosed with HNSCC between 1 January 2017 15 March 2020 (pre-COVID-19 period) 16 13 May 2021 (COVID-19 period). We calculated initial physician contact initiation performed descriptive exploratory statistical analyses. Results: median TBI decreased significantly (6 vs. 3 days; p = 0.008), while TTI not affected (28 29 0.972) pre-pandemic pandemic, respectively. Residence in village linked significant reduction (p 0.000), coinciding higher proportion rural oral cavity/oropharyngeal cancers (50.3% 67.4% 0.044). Median laryngeal tumors (27.5 18.5 0.012). Conclusions: study, one few region, provides insights into patient waiting times. Improvement likely resulted availability telemedicine, reduced diagnostic demands non-cancer patients, an increased incidence among patients.

Language: Английский

Citations

0
Análisis de la supervivencia de los pacientes con tumores malignos de cabeza y cuello diagnosticados durante la pandemia de COVID-19 DOI
Xavier León, Cristina Valero, Anna Holgado

et al.

Acta Otorrinolaringológica Española, Journal Year: 2025, Volume and Issue: 76(2), P. 106 - 115

Published: Feb. 16, 2025

Citations

0
Effect of the COVID-19 pandemic and lockdown on cancer stage distribution and time to treatment initiation using cancer registry data of the Swiss cantons of Zurich and Zug from 2018 to 2021 DOI Creative Commons
Flurina Suter, Miriam Wanner, Andreas Wicki

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(2)

Published: Feb. 21, 2025

Swiss healthcare institutions conducted only urgent procedures during the COVID-19 lockdown, potentially leading to a lack of care for other severe diseases, such as cancer. We examined effects pandemic on cancer stage distribution and time between diagnosis treatment initiation using population-based registry data. The study was based data cantons Zurich Zug from 2018 2021. Cancer analysed descriptively with Pearson's Chi-squared test. Time determined in days by fitting Quasipoisson regression models. For all-cancer colorectal, lung, prostate statistically significant evidence difference stages among incidence years observed. Based models, longer (TTI) observed patients diagnosed 2021 receiving surgery (Rate Ratio = 1.08 [95% confidence interval 1.03, 1.14]) or hormone therapy (1.20 [1.03, 1.40]) compared those 2018/19 therapies. no TTI 2020 any therapies investigated, except chemotherapy shorter (0.92 [0.86, 0.98]). outcomes coincided beginning Switzerland onwards. Short- long-term public system were However, we cannot exclude that implementation new law registration explains part our observations.

Language: Английский

Citations

0
The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study DOI Open Access
Andrew Williamson, Alison E Lim,

FR Green

et al.

Head & Neck, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Background To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) describe survival outcomes. Methods Post hoc subgroup analysis a retrospective national observational cohort was conducted. All patients with rHNSCC who received definitive treatment decision between September 1, 2021 November 30, were included. Survival stratified according to subsite, primary versus disease, surgical nonsurgical treatment. Results Data from 202 derived 1488 submitted by 50 UK centers. Median age 66 years (IQR 58–74), 142 (70.3%) male. The most common recurrence subsites oropharynx (20.5%), oral cavity (19.5%), larynx (16.4%), hypopharynx (14.9%). Ninety‐three (48.4%) managed curatively. Surgery for laryngeal (59.4%), (60.5%), hypopharyngeal (44.8%), oropharyngeal (37.5%) cancers. Two‐year overall (OS), disease‐free (DFS), disease‐specific (DSS), local free (LRFS) 41.1%, 39.1%, 42.2%, 39.3%, respectively. treated surgery had improved OS ( p = 0.0005), DFS 0.012), DSS 0.0003), LRFS 0.007), over treatments. Compared cancers, presents more advanced T stage < 0.001) distant metastasis 0.001), receives less curative has worse outcomes (all 0.001). On multivariate analysis, salvage surgery, radiotherapy, p16 status independent prognostic factors all Conclusions Recurrent HNSCC is associated high rates incurable disease than remains in rHNSCC, however future studies are necessary improve patient selection optimize following

Language: Английский

Citations

1