Effective non-invasive brain stimulation over dorsolateral prefrontal cortex for modulation of food craving and consumption: A systematic and meta-analytic review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111271 - 111271

Published: Jan. 1, 2025

Language: Английский

---

Alterations and potential associations of repetitive transcranial magnetic stimulation on body weight in stable schizophrenic patients

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 28, 2025

Although antipsychotic medications are effective in managing schizophrenia (SCZ), there still no strategies or preventive measures to address the weight gain associated with long-term use of these medications. We performed a single-blind, randomized, sham-controlled clinical trial explore efficacy noninvasive high-frequency repetitive transcranial magnetic stimulation (rTMS) technology reducing body patients SCZ. Fifty-three obese chronic stable SCZ (BMI ≥30 kg/m2) completed 4-week intervention study. The primary outcomes were changes and mass index (BMI) before after rTMS intervention. Secondary included psychiatric symptoms, cognitive function, routine blood indicators Significant BMI found active group (mean change = -2.25 kg, P < 0.01; mean -0.08, 0.001). Weight decreased significantly more compared sham 4 weeks (all 0.05). In group, immediate memory, attention, delayed memory elevated (P Delayed was relative correlated attention total score Our findings indicate that could serve as potential method for

Language: Английский

---

Reduced plasma interleukin-6 concentration after transcranial direct current stimulation to the prefrontal cortex

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 474, P. 115201 - 115201

Published: Aug. 14, 2024

Language: Английский

---

The role of impulsivity and binge eating in outpatients with overweight or obesity. A temporal discounting trial

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Background: Binge eating (BE) is associated with a range of cognitive control deficits related to impulsivity, including lower response inhibition, preference for immediate gratification, and maladaptive decision-making. The aim was investigate whether impulsivity BE may interact the decision process underlying brain activity in obese or overweight outpatients who are starting treatment achieve weight loss. Methods: A sample 26 treatment-seeking without evaluated binge eating, temporal discounting rates. Impulsivity measured Barratt Impulsiveness Scale (BIS-11), Eating (BES), changes subjective value rewards Temporal Discounting Task (TDt). Brain recorded through high-density electroencephalogram (hd-EEG) during TDt. Results: Patients reported more impulsive tendencies perceived sooner as gratifying when both options were delayed (p=0.02). reward choice TDt accompanied by an EEG alpha rhythm desynchronization parietal areas. Conclusions: tendency favor constitute obstacle obtaining adherence plans loss goals outpatients. Clinicians therefore encouraged include psychological outcomes such dysfunctional behaviors designing program. Trial registration: This study approved Ethics Committee Department Psychological, Health, Territorial Sciences University G. d’Annunzio Chieti-Pescara (Prot. n. 254 03/14/2017)

Language: Английский

---

Urban diabetes: analysis of diabetes prevalence in cities of the Lombardy region participating in the cities changing diabetes project

Acta Diabetologica, Journal Year: 2024, Volume and Issue: 61(12), P. 1569 - 1576

Published: July 1, 2024

Language: Английский

---

Transcranial Direct Current Stimulation for Food Craving in Women Affected by Overweight and Obesity: A Randomized Controlled Trial

European Addiction Research, Journal Year: 2024, Volume and Issue: 30(4), P. 197 - 206

Published: Jan. 1, 2024

<b><i>Introduction:</i></b> Craving is a multifactorial behavior caused by central circuit imbalance. The proposed treatments involve exercise and reduced food intake. However, the frequently fail. This study aimed to investigate effect of 10 consecutive sessions anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex on craving eating consumption women affected overweight obesity. <b><i>Methods:</i></b> A randomized double-blind controlled trial with 50 volunteers was divided into two groups (active-tDCS: <i>n</i> = 25 sham-tDCS: 25). There were total tDCS (2 mA, for 20 min) an F4 anodal-F3 cathodal montage. We evaluated effects (food craving, uncontrolled eating, emotional cognitive restriction), (calories macronutrients), anthropometric body composition variables (weight, mass index, waist circumference, fat percentage). <b><i>Results:</i></b> no statistically significant results between at baseline regarding sociodemographic clinical characteristics. Also, there interaction time versus group any studied. Treatment well tolerated serious adverse effects. <b><i>Conclusions:</i></b> In obesity cravings, (anodal) F3 (cathodal) did not produce changes in behavior, consumption, composition.

Language: Английский

---

Newly Developed Craving for Swiss Chocolate

Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(4), P. 675 - 677

Published: July 14, 2024

Craving, addiction, and compulsive eating leading to obesity are major public health problems incurring estimated direct indirect costs of up $600 billion.1 The opioid crisis, declared as a emergency in 2017, showed that there is still insufficient understanding craving, thereby hampering the ability treat it effectively. Studies have strived identify neuronal correlates addiction,2 isolation brain networks mainly based frontal lobe. Evidence from experimental animal human studies suggested role orbito-frontal cortex (OFC).2, 3 However, our knowledge, no reports new-onset craving due circumscribed lesion corroborate this notion. This report presents first case targeting Swiss chocolate, minor postoperative fronto-orbital bleeding, dissipating over time disappeared. A patient aged his 50s, right-handed, with an unremarkable medical psychiatric history was admitted department after generalized epileptic seizure. Brain magnetic resonance imaging voluminous mass suggesting frontobasal meningioma surrounding edema (Fig 1A). He prescribed levetiracetam 500 mg b.i.d. Four days later, he underwent neurosurgery complete tumor resection, leaving small compressive hematoma left OFC 1B–D). Histopathology confirmed meningioma, World Health Organization grade I. hospital 9 normal physical examination. To determine if antiseizure medication (levetiracetam) could be discontinued, referred ambulatory epileptology. There were further seizures or suspicious events, awake asleep. Levetiracetam well tolerated. Two weeks surgery, started notice strong for particularly, dark chocolate hazelnuts, had consume at least 200–300 g daily. became irritable nervous wife did not purchase special type would search throughout metropolitan Geneva, even shops closed (eg, driving 30 min airport buy specific chocolate). never lost control physically violent) suffered significant withdrawal symptoms sweating) newly developed craving. rant rail family get chocolate. Before neurosurgery, patient's desire particularly strong. smoke, only drank alcohol occasionally. ride bike regularly, without changes frequency intensity activity before operation. impressed neurology team slim, sporty figure evidence weight gain. His decreased gradually 4 months postoperatively, completely disappeared within year. carried out 6 operation regression 1E,F). seizure recurrence during years follow-up onset any other neurological illness. clinical OFC, psychophysiological "fix" (here, chocolate) low. Craving appeared consequence surgical intervention which led mesial fronto-basal spontaneously resolved months. Its disappearance coincided resolution symptoms. It established patients frontotemporal dementia present personality changes, including impulsive repetitive behavior.4 addiction behavior rely on particular network key structures, involves lobe; is, ventromedial dorsolateral prefrontal cortex, anterior cingulate gyrus, OFC.2 Synaptic potentiation transmission dorsal striatum represents neural correlate drives reinforcement, defining symptom addiction.3 In study healthy consumers, altered found medial OFC,5 concordant site patient. Hypoactivity acute lesions, appears basis behavior.2 Imaging revealed decreases orbitofrontal dependence, reactivation episodes.2 Although (or food general), alcohol, heroin differ significantly various neurobiological societal aspects, subserving anatomical seems similar implicates OFC. An alternative explanation new itself. Yet, I grow very slowly, should been As aforementioned, interest neurosurgery. transient lesion's origin identified left-sided despite literature supporting lateralized Deep stimulation studies, furthermore, target both hemispheres.6 New obsessive-compulsive disorder followed by bleeding described lobe,7 whereas right dominance noted "Gourmand syndrome," high-quality stroke traumatic injury.8 involved bilateral lesions hematoma. Food probably most frequent worldwide, morbidity associated. recent review 19 randomized trials noninvasive active resulted lower body index craving.9 For reasons, difficult reach stimulation, but these constraints might overcome appropriate targeting,10 opening therapeutic avenues those unable their compulsions. Careful distinct different parts necessary learn more about behavior, humans. Such knowledge may help design effective personalized treatment options cope large number people suffering persistent compulsions addictions ensuing society, worldwide prevailing. M.S. supported SNF 180365. All authors contributed conception manuscript. I.B.R. charge data acquisition preparation figures. reviewing/editing final approval Nothing report. confirm findings available article. Data S1. Supporting Information. Please note: publisher responsible content functionality information supplied authors. Any queries (other than missing content) directed corresponding author

Language: Английский

---

How to Treat Compulsive Facets of Behavioural Addictions

Current Addiction Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Language: Английский

---

The role of impulsivity and binge eating in outpatients with overweight or obesity: an EEG temporal discounting study

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 3, 2024

Binge eating (BE) is associated with a range of cognitive control deficits related to impulsivity, including lower response inhibition, preference for immediate gratification, and maladaptive decision-making. The aim was investigate whether impulsivity BE may interact the decision process underlying brain activity in outpatients overweight or obesity who are starting treatment achieve weight loss. A sample 26 treatment-seeking evaluated BE, temporal discounting rates. Impulsivity measured Barratt Impulsiveness Scale (BIS-11), according which two groups were composed: high BIS low BIS; assessed disorders module Structured Clinical Interview DSM5—Research Version, (BE group) without (NBE group). Changes subjective value rewards Temporal Discounting Task (TDt) where participants had choice between sooner but smaller vs. later larger monetary rewards. These choices made differently delayed conditions ("Now" "Not-now"). Brain rhythms recorded through high-density electroencephalogram (hd-EEG) during TDt. Patients reported more impulsive tendencies perceived as gratifying when both options (Not-now condition, p = 0.02). reward TDt accompanied by general EEG alpha band desynchronization parietal areas observed differences experimental patients groups. No effects within Now condition other bands. tendency favor constitute an obstacle adhering plans achieving loss goals obesity. Clinicians therefore encouraged include psychological factors, such dysfunctional behaviors, designing programs. By addressing these aspects, clinicians can better support overcoming barriers adherence sustainable This study approved Ethics Committee Department Psychological, Health, Territorial Sciences University G. d'Annunzio Chieti-Pescara (Prot. n. 254 03/14/2017). Although health risk widely acknowledged, treatments often unsuccessful long term due several factors. might explain some reduced benefits from treatments. In this study, we investigated processes among obesity, looked at their activity. tended be prefer compared ones. all patients, α oscillations lobe have been play dominant role processes. help long-term success plans. also provide useful information working

Language: Английский

---

Transcranial Magnetic Stimulation: A New Possibility in Obesity Treatment

The Open Neurology Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Sept. 30, 2024

Obesity is a major public health challenge and results from the complex interaction of many etiopathogenetic factors. However, food-related hedonic stimuli poor inhibitory control often appear to be specific maintenance factors, conventional treatments are sometimes ineffective. Transcranial magnetic stimulation emerging as promising treatment option. Targeting brain regions, such dorsolateral prefrontal cortex, was found effective in modulating acute food craving improving cognitive control. This review traces evolution development transcranial presents recent randomized clinical trials conducted obese subjects. These suggest that repetitive deep may reducing body weight, BMI cravings. The neural circuits involved underlying mechanisms action this neurostimulation technique also reviewed. Finally, outstanding questions future research directions identified further understand develop therapy.

Language: Английский

---