IRE1α pathway: A potential bone metabolism mediator DOI Creative Commons

Chengbo Yu,

Zhixiang Zhang, Li Xiao

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(10)

Published: May 12, 2024

Abstract Osteoblasts and osteoclasts collaborate in bone metabolism, facilitating development, maintaining normal density strength, aiding the repair of pathological damage. Endoplasmic reticulum stress (ERS) can disrupt intracellular equilibrium between osteoclast osteoblast, resulting dysfunctional metabolism. The inositol‐requiring enzyme‐1α (IRE1α) pathway—the most conservative unfolded protein response pathway activated by ERS—is crucial regulating cell This involvement encompasses functions such as inflammation, autophagy, apoptosis. Many studies have highlighted potential roles IRE1α osteoblasts, chondrocytes, its implication certain bone‐related diseases. These findings suggest that it may serve a mediator for However, relevant reviews on role metabolism remain unavailable. Therefore, this review aims to explore recent research elucidated intricate specifically osteogenesis, chondrogenesis, osteoclastogenesis, osteo‐immunology. provide novel insights into treating

Language: Английский

Protective effect of curcumin against endoplasmic reticulum stress and lipid metabolism disorders in AFB1-intoxicated duck liver DOI
Qian Su, Hang Pan,

Panjing Hong

et al.

Mycotoxin Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

Citations

0
Agrin-deficient osteocytes disrupt bone tissue homeostasis in male mice DOI
Maria Paula Oliveira Gomes, Letícia Faustino Adolpho, Alann Thaffarell Portilho Souza

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142551 - 142551

Published: March 1, 2025

Language: Английский

Citations

0
IRE1α pathway: A potential bone metabolism mediator DOI Creative Commons

Chengbo Yu,

Zhixiang Zhang, Li Xiao

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(10)

Published: May 12, 2024

Abstract Osteoblasts and osteoclasts collaborate in bone metabolism, facilitating development, maintaining normal density strength, aiding the repair of pathological damage. Endoplasmic reticulum stress (ERS) can disrupt intracellular equilibrium between osteoclast osteoblast, resulting dysfunctional metabolism. The inositol‐requiring enzyme‐1α (IRE1α) pathway—the most conservative unfolded protein response pathway activated by ERS—is crucial regulating cell This involvement encompasses functions such as inflammation, autophagy, apoptosis. Many studies have highlighted potential roles IRE1α osteoblasts, chondrocytes, its implication certain bone‐related diseases. These findings suggest that it may serve a mediator for However, relevant reviews on role metabolism remain unavailable. Therefore, this review aims to explore recent research elucidated intricate specifically osteogenesis, chondrogenesis, osteoclastogenesis, osteo‐immunology. provide novel insights into treating

Language: Английский

Citations

3