Berberine Inhibits Abdominal Aortic Aneurysm Formation and Vascular Smooth Muscle Cell Phenotypic Switching by Regulating the Nrf2 Pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(7)

Published: April 1, 2025

ABSTRACT Abdominal aortic aneurysm (AAA) is a life‐threatening disease featuring extensive membrane destruction in the vascular wall, which closely associated with phenotypic switching of smooth muscle cells (VSMC). A thorough understanding changes regulatory factors during pathogenesis VSMC essential for medical treatments AAA. NRF2 was deemed to hold pivotal position developing AAA, especially as it can regulate switching. In this study, we found that berberine prevents formation AAA by regulating VSMC, well validated both vitro and vivo functional experiments. Mechanically, regulates promoting expression downstream contraction genes through deubiquitination Keap1, deubiquitinating enzyme USP15 plays an important mediating role process.

Language: Английский

Lipocalin‐2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(12)

Published: July 18, 2024

Aerobic glycolysis is involved in the pathogenesis of pulmonary hypertension (PH). The mechanisms by which increased and how it contributes to vascular remodelling are not yet fully understood. In this study, we demonstrated that elevated lipocalin-2 (LCN2) PH significantly enhances aerobic human artery smooth muscle cells (PASMCs) up-regulating LDHA expression. Knockout Lcn2 or having heterozygous deficiency mice inhibits progression hypoxic PH. Our study reveals LCN2 stimulates expression activating Akt-HIF-1α signalling pathway. Inhibition Akt HIF-1α reduces proliferation PASMCs. Both play critical roles development suppressed vessels lacking LCN2. These findings shed light on LCN2-Akt-HIF1α-LDHA axis

Language: Английский

Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(12), P. 720 - 730

Published: Nov. 25, 2024

Timely and accurate evaluation of the patient's pulmonary arterial pressure (PAP) is great significance for treatment congenital heart disease. Currently, there no non-invasive gold standard method evaluating PAP.

Language: Английский