Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(12)

Published: July 18, 2024

Traumatic optic neuropathy refers to nerve (ON) injury by trauma, including explosion and traffic accident. Retinal ganglion cell (RGC) death is the critical pathological cause of irreversible visual impairment blindness in ON injury. We previously investigated patterns 11 modes mouse retina post-ON Here we aimed identify additional signalling pathways regulating RGC survival rodents RNA sequencing analysis identified upregulation inflammation cellular senescence-related genes injury, which were confirmed immunoblotting immunofluorescence analyses. Increased expression senescence-associated β-galactosidase (SA-βgal) RGCs activation microglia also found. Transforming growth factor-β receptor type II inhibitor (LY2109761) treatment suppressed p15

Language: Английский