CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention DOI Open Access

Nour Maatouk,

Abdallah Kurdi,

Sarah Marei

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13056 - 13056

Published: Dec. 4, 2024

Breast cancer (BC) remains a significant global health issue, necessitating advanced molecular approaches for early detection and prevention. This review delves into the roles of microRNAs (miRNAs) circular RNAs (circRNAs) in BC, highlighting their potential as non-invasive biomarkers. Utilizing silico tools databases, we propose novel methodology to establish mRNA/circRNA/miRNA axes possibly indicative possible We that during tumor initiation, some changes oncogene or suppressor gene expression (mRNA) are mirrored by alterations corresponding circRNAs reciprocal sponged miRNAs affecting tumorigenesis pathways. used two Gene Expression Omnibus (GEO) datasets identified five initiation further validated proposed through Kaplan-Meier (KM) plot enrichment analysis miRNA using patient data. Evaluating coupled differential body fluids exosomes provides greater confidence than assessing either, with more providing even confidence. The not only improves BC reliability but also has applications other cancers, enhancing preventive measures.

Language: Английский

Plasma protein levels and hepatocellular carcinoma: a Mendelian randomization study with drug screening implications DOI Creative Commons

Longhui Xie,

Dekun Song,

Jianwei Lan

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 19, 2025

Language: Английский

Citations

0
CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention DOI Open Access

Nour Maatouk,

Abdallah Kurdi,

Sarah Marei

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13056 - 13056

Published: Dec. 4, 2024

Breast cancer (BC) remains a significant global health issue, necessitating advanced molecular approaches for early detection and prevention. This review delves into the roles of microRNAs (miRNAs) circular RNAs (circRNAs) in BC, highlighting their potential as non-invasive biomarkers. Utilizing silico tools databases, we propose novel methodology to establish mRNA/circRNA/miRNA axes possibly indicative possible We that during tumor initiation, some changes oncogene or suppressor gene expression (mRNA) are mirrored by alterations corresponding circRNAs reciprocal sponged miRNAs affecting tumorigenesis pathways. used two Gene Expression Omnibus (GEO) datasets identified five initiation further validated proposed through Kaplan-Meier (KM) plot enrichment analysis miRNA using patient data. Evaluating coupled differential body fluids exosomes provides greater confidence than assessing either, with more providing even confidence. The not only improves BC reliability but also has applications other cancers, enhancing preventive measures.

Language: Английский

Citations

1