FOSB is a key factor in the genetic link between inflammatory bowel disease and acute myocardial infarction: multiple bioinformatics analyses and validation DOI Creative Commons

Qingan Fu,

Tianzhou Shen,

Weihan Qiu

et al.

BMC Medical Genomics, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 3, 2025

Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, is associated with an increased risk of Acute Myocardial Infarction (AMI). The genetic mechanisms underlying this link are not well understood. We downloaded IBD AMI-related microarray datasets from the NCBI Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified analyzed using enrichment analysis Weighted Co-expression Network Analysis (WGCNA). Machine learning techniques, including LASSO, random forest, Boruta, employed to screen for hub genes. These validated through qRT-PCR Western blotting. Single-cell sequencing was used confirm findings. Additionally, potential therapeutic targets Connectivity Map (CMap) Five key genes-THBD, FOSB, ADGPR3, IL1R2, PLAUR-were as significantly involved in both AMI pathogenesis. A diagnostic model constructed these demonstrated high predictive accuracy. several drugs targeting identified, offering new avenues. This study highlights crucial role FOSB other comorbidity AMI. findings provide novel insights early diagnosis strategies, emphasizing importance further investigation into links.

Language: Английский

Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy DOI Creative Commons
Yanru Ren, Kun Wang, Yuanyuan Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140488 - 140488

Published: Jan. 29, 2025

Language: Английский

Citations

1
Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus DOI Creative Commons
Xu He, Wei Zhao, Ping Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Glucagon-like peptide-1 (GLP-1) is a 30-amino acid intestinal insulin-stimulating factor, which mainly secreted by L cells in the distal ileum and colon. It has various physiological functions, such as promoting insulin secretion synthesis, stimulating β-cell proliferation, inducing islet regeneration, inhibiting apoptosis glucagon release, delaying gastric emptying controlling appetite, etc. plays role through specific GLP-1 receptor (GLP-1R) distributed many organs or tissues participates regulation of glucose homeostasis body. agonists (GLP-1RAs) similar function GLP-1. Because its structural difference from natural GLP-1, it not easy to be degraded dipeptidyl peptidase-4 (DPP-4), thus prolonging action time. GLP-1RAs have been recognized new type hypoglycemic drugs widely used treatment 2 diabetes mellitus (T2DM). Compared with other non-insulin drugs, can only effectively reduce blood glycosylated hemoglobin (HbA1c), but also protect cardiovascular system, nervous system kidney without causing hypoglycemia weight gain. Therefore, good application prospects potential for further development.

Language: Английский

Citations

0
FOSB is a key factor in the genetic link between inflammatory bowel disease and acute myocardial infarction: multiple bioinformatics analyses and validation DOI Creative Commons

Qingan Fu,

Tianzhou Shen,

Weihan Qiu

et al.

BMC Medical Genomics, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 3, 2025

Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, is associated with an increased risk of Acute Myocardial Infarction (AMI). The genetic mechanisms underlying this link are not well understood. We downloaded IBD AMI-related microarray datasets from the NCBI Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified analyzed using enrichment analysis Weighted Co-expression Network Analysis (WGCNA). Machine learning techniques, including LASSO, random forest, Boruta, employed to screen for hub genes. These validated through qRT-PCR Western blotting. Single-cell sequencing was used confirm findings. Additionally, potential therapeutic targets Connectivity Map (CMap) Five key genes-THBD, FOSB, ADGPR3, IL1R2, PLAUR-were as significantly involved in both AMI pathogenesis. A diagnostic model constructed these demonstrated high predictive accuracy. several drugs targeting identified, offering new avenues. This study highlights crucial role FOSB other comorbidity AMI. findings provide novel insights early diagnosis strategies, emphasizing importance further investigation into links.

Language: Английский

Citations

0