Organoids-on-Chips Technology: Unveiling New Perspectives in Rare-Disease Research DOI Open Access
Xiangyang Li, Hui Wang, Xiaoyan You

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4367 - 4367

Published: May 4, 2025

The scarcity of robust models and therapeutic options for rare diseases continues to hamper their preclinical investigation. Traditional animal two-dimensional cell cultures are limited in ability replicate human heredity-associated traits complex pathological features. Organoids-on-a-chip approaches open up new frontiers rare-disease research via the integration organ chips organoid technology. This integrative strategy offers immense opportunities mimicry disease-related traits, clarification mechanisms underlying disease, prediction treatment responses a highly human-related manner. forward-looking perspective suggests organoids on transformative tools parsing pathogenesis, accelerating discovery, bridging gap between basic precision medicine.

Language: Английский

Organoids-on-Chips Technology: Unveiling New Perspectives in Rare-Disease Research DOI Open Access
Xiangyang Li, Hui Wang, Xiaoyan You

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4367 - 4367

Published: May 4, 2025

The scarcity of robust models and therapeutic options for rare diseases continues to hamper their preclinical investigation. Traditional animal two-dimensional cell cultures are limited in ability replicate human heredity-associated traits complex pathological features. Organoids-on-a-chip approaches open up new frontiers rare-disease research via the integration organ chips organoid technology. This integrative strategy offers immense opportunities mimicry disease-related traits, clarification mechanisms underlying disease, prediction treatment responses a highly human-related manner. forward-looking perspective suggests organoids on transformative tools parsing pathogenesis, accelerating discovery, bridging gap between basic precision medicine.

Language: Английский

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