Studying of anti‐inflammatory and antioxidant effects of tectorigenin in ovalbumin‐induced asthma mice models

The Clinical Respiratory Journal, Journal Year: 2024, Volume and Issue: 18(4)

Published: April 1, 2024

Abstract Background Allergic asthma is an important respiratory system problem characterized by airway inflammation, breathlessness, and bronchoconstriction. its outcomes are triggered type 2 allergic immune responses. Tectorigenin a methoxy‐isoflavone with anti‐inflammatory effects. In this study, we investigated the effects of tectorigenin on pathophysiology in animal model. Methods Asthmatic mice were treated tectorigenin. Then hyperresponsiveness (AHR), eosinophil percentage, levels interleukin (IL)‐33, IL‐25, IL‐13, IL‐5, IL‐4, total ovalbumin (OVA)‐specific immunoglobulin (Ig)E, lung histopathology evaluated. Result significantly (P 〈 0.05) reduced infiltration (41 ± 7%) broncho‐alveolar lavage fluid (BALF), serum IL‐5 level 5, pg/mL), bronchial vascular inflammation (scores 1.3 0.2 1.1 0.3, respectively) but had no significant AHR, IL‐33, −25, −13, −4 (403 24, 56 7, 154 11, 89 6 pg/mL, respectively), OVA‐specific IgE (2684 265 264 19 ng/mL, goblet cell hyperplasia, mucus production. Conclusion could control secretion inflammatory mediators asthma, so it can be regarded as potential antiasthma treatment ability to eosinophilia‐related problems.

Language: Английский

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Experimental Research Progress on the Treatment of Type 2 Inflammatory Asthma with Traditional Chinese Medicines and Their Active Ingredients

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(11), P. 1438 - 1447

Published: Jan. 1, 2024

Language: Английский

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