Beyond donation to organ utilization in the USA

Current Opinion in Organ Transplantation, Journal Year: 2023, Volume and Issue: 28(3), P. 197 - 206

Published: March 9, 2023

Purpose of review The deceased donor organ pool has broadened beyond young, otherwise healthy head trauma victims. But an abundance donated organs only benefits patients if they are accepted, expeditiously transported and actually transplanted. This focuses on postdonation challenges opportunities to increase the number transplants through improved utilization. Recent findings We build upon recently proposed changes in terminology for measuring Among recovered transplant, nonuse rate (NUR REC ) risen above 25% kidneys pancreata. donors, DON 40% livers exceeds 70% thoracic organs. Programme-level variation offer acceptance rates vastly traditional, 1-year survival benchmark. Key boost utilization include donation after circulatory death hepatitis C virus (HCV)+ organs; acute kidney injury suboptimal biopsy kidneys; older steatotic livers. Summary Underutilization less-than-ideal, yet transplant-worthy remains obstacle maximizing impact U.S. transplant system. increased risk inferior posttransplant outcomes must always be weighed against risks remaining waitlist. Advanced perfusion technologies; tuning allocation systems placement efficiency; data-driven clinical decision support have potential medically complex

Language: Английский

Normothermic Machine Perfusion Is Associated With Improvement in Mortality and Graft Failure in Donation After Cardiac Death Liver Transplant Recipients in the United States

Transplantation Direct, Journal Year: 2024, Volume and Issue: 10(8), P. e1679 - e1679

Published: July 5, 2024

Use of normothermic machine perfusion (NMP) may help to expand the liver transplantation (LT) donor pool by potentially increasing utilization donation after circulatory death (DCD) organs. The aim this study was assess impact NMP on LT from DCD

Language: Английский