High Rate of Antibody Response to Multiple Doses of the COVID-19 Vaccine in Liver Transplant Recipients: Analysis of Predictive Factors DOI Creative Commons
N. Zignani, Andrea Costantino,

Michele Sagasta

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 352 - 352

Published: March 26, 2025

The COVID-19 pandemic highlighted the vulnerability of immunocompromised individuals, including liver transplant recipients (LTRs), who often exhibit reduced vaccine immunogenicity. While initial doses and subsequent boosters improved immune response, LTRs were prioritized for vaccination. Studies have shown increased antibody response after each booster dose. Vaccine hesitancy, defined as delayed or refused vaccination despite availability, poses a public health challenge, fueled by misinformation. This study aimed to evaluate anti-spike responses in vaccinated two at least one booster, also assessing adherence doses. We conducted retrospective observational center Milan, Italy, between January 2021 December 2023. had received four more mRNA vaccines (Pfizer Moderna) included. Anti-spike levels measured 60-80 days Data on status collected 2024. Statistical analysis was performed compare identify predictive factors. showed significant increase first compared second dose with trend versus further following fourth subgroup patients receiving However, decreased over time. In LTRs, predictors weaker chronic kidney disease metabolic etiology transplant. that multiple led continuous responses. progressive decline "to doses" should be related fact spread programs worldwide, is still current infection, but it much less severe than before.

Language: Английский

High Rate of Antibody Response to Multiple Doses of the COVID-19 Vaccine in Liver Transplant Recipients: Analysis of Predictive Factors DOI Creative Commons
N. Zignani, Andrea Costantino,

Michele Sagasta

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 352 - 352

Published: March 26, 2025

The COVID-19 pandemic highlighted the vulnerability of immunocompromised individuals, including liver transplant recipients (LTRs), who often exhibit reduced vaccine immunogenicity. While initial doses and subsequent boosters improved immune response, LTRs were prioritized for vaccination. Studies have shown increased antibody response after each booster dose. Vaccine hesitancy, defined as delayed or refused vaccination despite availability, poses a public health challenge, fueled by misinformation. This study aimed to evaluate anti-spike responses in vaccinated two at least one booster, also assessing adherence doses. We conducted retrospective observational center Milan, Italy, between January 2021 December 2023. had received four more mRNA vaccines (Pfizer Moderna) included. Anti-spike levels measured 60-80 days Data on status collected 2024. Statistical analysis was performed compare identify predictive factors. showed significant increase first compared second dose with trend versus further following fourth subgroup patients receiving However, decreased over time. In LTRs, predictors weaker chronic kidney disease metabolic etiology transplant. that multiple led continuous responses. progressive decline "to doses" should be related fact spread programs worldwide, is still current infection, but it much less severe than before.

Language: Английский

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