Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(5), P. 1309 - 1319

Published: April 16, 2024

Abstract Cancer of unknown primary (CUP) site poses diagnostic challenges due to its elusive nature. Many cases CUP manifest as pleural and peritoneal serous effusions. Leveraging cytological images from 57,220 at four tertiary hospitals, we developed a deep-learning method for tumor origin differentiation using histology (TORCH) that can identify malignancy predict in both hydrothorax ascites. We examined performance on three internal ( n = 12,799) two external 14,538) testing sets. In sets, TORCH achieved area under the receiver operating curve values ranging 0.953 0.991 cancer diagnosis 0.979 localization. accurately predicted origins, with top-1 accuracy 82.6% top-3 98.9%. Compared results derived pathologists, showed better prediction efficacy (1.677 versus 1.265, P < 0.001), enhancing junior pathologists’ scores significantly (1.326 1.101, 0.001). Patients whose initial treatment protocol was concordant TORCH-predicted origins had overall survival than those who were administrated discordant (27 17 months, 0.006). Our study underscores potential valuable ancillary tool clinical practice, although further validation randomized trials is warranted.

Language: Английский

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Needle tracking and segmentation in breast ultrasound imaging based on spatio-temporal memory network

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 17, 2025

Ultrasound-guided needle biopsy is a commonly employed technique in modern medicine for obtaining tissue samples, such as those from breast tumors, pathological analysis. However, it limited by the low signal-to-noise ratio and complex background of ultrasound imaging. In order to assist physicians accurately performing biopsies on tissues, minimize complications, avoid damage surrounding computer-aided segmentation tracking has garnered increasing attention, with notable progress made recent years. Nevertheless, challenges remain, including poor image quality, high computational resource requirements, various shape. This study introduces novel Spatio-Temporal Memory Network designed ultrasound-guided tumor biopsy. The proposed network integrates hybrid encoder that employs CNN-Transformer architectures, along an optical flow estimation method. From Ultrasound Imaging Department at First Affiliated Hospital Shantou University, we developed real-time dataset specifically puncture procedures which includes video data collected 11 patients. Experimental results demonstrate this model significantly outperforms existing methods improving positioning accuracy enhancing stability. Specifically, performance metrics follows: IoU 0.731, Dice 0.817, Precision 0.863, Recall 0.803, F1 score 0.832. By advancing precision localization, contributes enhanced reliability biopsy, ultimately supporting safer more effective clinical outcomes. paper demonstrates robust needles imaging, offering dependable technical support procedures.

Language: Английский

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One‐Stop Diagnosis in Interventional Pathology: A 7‐Year Experience With On‐Demand Care for Superficial Nodules

Cytopathology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The growing demand for specialised healthcare often results in prolonged waiting times diagnostic procedures, particularly oncological pathology. Interventional pathology, wherein pathologists perform sample collection and diagnosis, offers a potential solution through same-day services. This study aims to describe the operational framework of One-Stop interventional pathology consultation analyse its outcomes, focusing on response performance patients with superficial nodules. retrospective was conducted tertiary hospital from 2016 2023. involved ultrasound-guided fine needle aspiration (USFNA) core biopsy (USCNB) performed by an pathologist. Data procedure adequacy, times, outcomes were collected analysed. A total 877 procedures (718 USFNA, 159 USCNB) performed. median time specialist request definitive diagnosis 2 days (interquartile range 1-4), 18% receiving same day. Adequacy rates 98.6% USFNA 100% USCNB, low non-diagnostic (USFNA: 3.2%; USCNB: 0.6%). Lymph nodes most commonly sampled organ, head-and-neck areas predominant anatomical sites. model significantly reduced improved patient experience. efficient, patient-centred approach demonstrates high accuracy rates, supporting viability broader adoption. Further multicentre studies are needed validate findings optimise implementation.

Language: Английский

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Resident training in interventional pathology: Ultrasound‐guided fine‐needle aspiration and rapid on site evaluation—5 years of teaching experience in a single university hospital

Cytopathology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Abstract Introduction Despite the established role of interventional pathologist, their diagnostic performance is difficult to establish. At least in Spain training pathology residents ultrasound‐guided procedures for specimen collection limited or absent most institutions. We present our teaching experience instruction fine‐needle aspiration (FNA) a tertiary‐level hospital. Materials and Methods The who rotated through unit department application FNA rapid on‐site evaluation (U‐ROSE) was documented over 5 years. period broken down into learning phases included number performed, anatomical location, performance, among other aspects. Results Nineteen (19) were trained U‐ROSE, performed total 4003 procedures, with mean 211 per resident. In 53% cases only one pass required an adequated sample. more than 97% cases. frequently sampled sites thyroid gland ( n = 2347), followed by lymph node 667), soft tissues 663) salivary glands 322). Conclusion results support programme which essential lay foundations future pathologist.

Language: Английский

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Uses and limitations of small‐volume biopsies for the diagnosis of lymphoma

Cytopathology, Journal Year: 2024, Volume and Issue: 35(4), P. 454 - 463

Published: March 10, 2024

Abstract Although surgical biopsy remains the gold standard for diagnosis of lymphoma, small‐volume biopsies including fine‐needle aspiration and core needle are increasingly being used as a first line diagnostic tool. Small‐volume safe, rapid cost effective; however, utility varies by lymphoma subtype. It is important pathologists clinicians to recognize both strengths limitations such biopsies.

Language: Английский

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None

Infezioni in Medicina, Journal Year: 2024, Volume and Issue: 32(2)

Published: May 30, 2024

Following the introduction of RNA-based vaccines, COVID-19 vaccine-associated clinical lymphadenopathy (C19-LAP) has been reported as a side effect.Moreover, subclinical detected on imaging (SLDI) also observed, mainly incidental findings while performing screening tests oncological patients.In these cases, surgical lymphadenectomy, fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) have used valuable diagnostic tool for SLDI C19-LAP.In this review clinical, histologic cytologic features C19-LAP investigated.A search studies that histopathology cytopathology was performed PubMed Google Scholar, 11 January 2023.Thirty-one reports were retrieved included in pooled analysis.In total, we 54 patients with median age 47 years.In our research, excision, CNB and/ or FNAC enlarged lymph nodes cases.Of all only two metastases diagnosed one case reactive hyperplasia atypical follicles.The remaining cases (28 cases), follicular (13 Kikuchi-Fujimoto disease (6 granulomatous lymphadenitis (2 eosinophilic node abscesses (1 case), Langherans cell histiocytosis Rosai-Dorfman case).SLDI represented dilemma, especially oncologic patients.The role different tools discussed.

Language: Английский

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COVID-19 vaccine-associated lymphadenopathy: a review

Infezioni in Medicina, Journal Year: 2024, Volume and Issue: 32(2)

Published: May 30, 2024

Following the introduction of RNA-based vaccines, COVID-19 vaccine-associated clinical lymphadenopathy (C19-LAP) has been reported as a side effect. Moreover, subclinical detected on imaging (SLDI) also observed, mainly incidental findings while performing screening tests oncological patients. In these cases, surgical lymphadenectomy, fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) have used valuable diagnostic tool for SLDI C19-LAP. this review clinical, histologic cytologic features C19-LAP investigated. A search studies that histopathology cytopathology was performed PubMed Google Scholar, 11 January 2023. Thirty-one reports were retrieved included in pooled analysis. total, we 54 patients with median age 47 years. our research, excision, CNB and/or FNAC or enlarged lymph nodes cases. Of all only two metastases diagnosed one case reactive hyperplasia atypical follicles. The remaining cases (28 cases), follicular (13 Kikuchi-Fujimoto disease (6 granulomatous lymphadenitis (2 eosinophilic node abscesses (1 case), Langherans cell histiocytosis Rosai-Dorfman case). represented dilemma, especially oncologic role different tools discussed.

Language: Английский

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Morphology quiz: Large inguinal lymphadenopathy in a young man

Cytopathology, Journal Year: 2024, Volume and Issue: 35(4), P. 523 - 525

Published: April 6, 2024

A 25‐year‐old male with fever, joint pain and inguinal masses. Lab tests reveal polyadenopathy. Negative serology. Ultrasound shows a 42 mm hypoechoic node. FNAC core‐needle biopsy show… what? Read the article to find out.

Language: Английский

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The Current and Future Impact of Lymph Node Fine-Needle Aspiration Cytology on Patient Care

Surgical pathology clinics, Journal Year: 2024, Volume and Issue: 17(3), P. 509 - 519

Published: May 23, 2024

Language: Английский

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