Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling

Development, Journal Year: 2021, Volume and Issue: 148(18)

Published: July 16, 2021

How dermis maintains tissue homeostasis in cyclic growth and wounding is a fundamental unsolved question. Here, we study how dermal components of feather follicles undergo physiological (molting) plucking injury-induced regeneration chickens. Proliferation analyses reveal quiescent, transient-amplifying (TA) long-term label-retaining cell (LRDC) states. During the phase, LRDCs are activated to make new with distinct cellular flows. Dermal TA cells, enriched proximal follicle, generate both peripheral pulp, which extends distally expand epithelial-mesenchymal interactive interface for barb patterning, central provides nutrition. Entering resting LRDCs, accompanying collar bulge epidermal descend apical papilla. In next cycle, these papilla re-activated become pulp progenitor cells. lower sheath can pulp. Transcriptome identify marker genes highlight molecular signaling associated specification. We compare topological changes those hair convergently evolved follicle configuration. This work presents model analyzing remodeling mesenchymal progenitors.

Language: Английский

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Making region-specific integumentary organs in birds: evolution and modifications

Current Opinion in Genetics & Development, Journal Year: 2021, Volume and Issue: 69, P. 103 - 111

Published: March 27, 2021

Language: Английский

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Genes influencing deposition of melanin in breast muscle of the Xuefeng black bone chicken based on bioinformatic analysis

Genome, Journal Year: 2023, Volume and Issue: 66(8), P. 212 - 223

Published: April 24, 2023

The Xuefeng black bone chicken (XFBC) represents an important poultry genetic resource. However, the darkness in breast muscle is heterogeneous. molecular mechanisms underlying melanogenesis of XFBC remains unclear. This study used RNA-seq to compare difference transcriptome between hyperpigmentation and hypopigmentation muscle. Six cDNA libraries were constructed for groups XFBC. We identified 395 differently expressed genes (DEGs) group (P < 0.05, |log2FC|≥1). Gene ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis indicated several differentially enriched biological functions pathways involved set (GSEA) GO two significant gene sets, including pigment metabolic process transmembrane receptor protein tyrosine kinase activity. GSEA-KEGG metabolism related with protein-protein interaction network was eight clustered module. nine hub genes, TYR, TYRP1, DCT, GPR143, MLANA, SLC24A5, GPNMB, MLPH, EDNRB2. Taken together, DEGs provide a solid basis regulatory

Language: Английский

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Genomic, genetic and phylogenetic evidence for a new falcon species using chromosome-level genome assembly of the gyrfalcon and population genomics

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 13, 2023

Abstract The taxonomic classification of a falcon population found in the Altai region Asia has been heavily debated for two centuries and previous studies have inconclusive, hindering more informed conservation approach. Here, we generated chromosome-level gyrfalcon reference genome using Vertebrate Genomes Project (VGP) assembly pipeline. Using whole sequences 44 falcons from different species populations, including “Altai” falcons, analyzed their structure, admixture patterns demographic history. We find that are genomically mosaic saker ancestries, carry distinct W- mitochondrial-haplotypes cluster with lanner falcon. haplotype diverged 422,000 years ago ancestor sakers gyrfalcons, both which, turn, split 109,000 ago. W chromosome includes coding variants may influence important structural, behavioral reproductive traits. These findings support designation as ( Falco altaicus ).

Language: Английский

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Body weight optimization of broiler breeder hens. 1. Pullet growth, feed efficiency, carcass composition, and sexual maturation

Poultry Science, Journal Year: 2024, Volume and Issue: unknown, P. 104414 - 104414

Published: Oct. 1, 2024

Language: Английский

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Transcriptional profiling of the M. complexus in naked neck chickens suggest a direct pleiotropic effect of GDF7 on feathering and reduced hatchability

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 15, 2024

Abstract Background The locus for naked neck ( Na ) in chickens reduces feather coverage and leads to increased heat dissipation from the body surface resulting better adaptability hot conditions. However, gene is linked significantly lower hatchability due an late embryonic mortality. It has been argued that causative GDF7 may have a direct pleiotropic effect on via its muscle development. Thus, study presented here analyses transcriptome of hatching M. complexus) shows how impacts development leading reduced rates chickens. Results Using 12 chicken embryos (6 x wildtype Wt 6 RNA was extracted complexus each embryo sequenced. differential expression led discovery 461 differentially expressed (DE) genes experimental group. Among those, 77 were uncertain function (LOC symbols), with 31 classified as uncharacterised. regulation number pathways involved normal development, found be negatively influenced by genotype. Further cell-cell adhesion, cell signalling pathways, amino acid (AA) metabolism/transport also observed. (alias BMP12 ), whose localised overexpression skin causes Na/Na phenotype, overexpressed embryos, significant increase binding sites transcription factor PITX2 Conclusion In chickens, under control mutated cis-regulatory element, actions are known suppress distribution feathers through sensitizing action retinoic acid. this study, DE over 10 response elements (RAREs) close proximity observed, indicating changes retinol metabolism. With understanding mutation activity, indicates high likelihood excerpting effect, not just observed reduction patterning, but impacting M.complexus , consequently birds Furthermore, enrichment complexus, still ongoing embryos. This suggests yet fully developed, further increasing potential mortality chicks at hatching.

Language: Английский

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Sequential introgression of a carotenoid processing gene underlies sexual ornament diversity in a genus of manakins

Science Advances, Journal Year: 2024, Volume and Issue: 10(47)

Published: Nov. 20, 2024

In a hybrid zone between two tropical lekking birds, yellow male plumage of one species has introgressed asymmetrically replacing white another via sexual selection. Here, we present detailed analysis the trait to uncover its physical and genetic bases trace evolutionary history. We determine that carotenoid lutein underlies phenotype describe microstructural feather features likely enhance color appearance. These same reduce predicted water shedding capacity feathers, potential liability in tropics. Through genome-scale DNA sequencing hybrids each genus, identify BCO2 as major gene responsible for polymorphism. The tree genome-wide allele frequency patterns suggest carotenoid-pigmented collars initially arose third reached through historical flow. Complex interplay selection hybridization thus shaped phenotypes these species, where conspicuous traits are key reproductive success.

Language: Английский

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Research Note: Identification of breeding-related candidate genes in Tianjin-monkey chickens by transcriptome analysis

Poultry Science, Journal Year: 2023, Volume and Issue: 102(10), P. 102928 - 102928

Published: July 9, 2023

Tianjin-monkey Chicken is a locally bred dual-purpose naked neck poultry with high tolerance to heat stress and poor reproductive ability. We aim explore breeding-related genes promote its growth, reproduction, meat, egg performances. In this study, purebred, crossbred neck-naked neck-feathered Chickens (male = 5 female in each group) were sampled for transcriptome analysis. Differential gene expression analysis was performed identify candidate based on mRNA profiles. Functional enrichment analyses including GO, KEGG GSEA conducted. Forty-five identified, which significantly enriched pathways 37 GO terms. Some of the considered be valuable guiding breeding future, SPRY3, CPXM2, FST, HDDC2, TLR1B, CYBB, EHHADH.

Language: Английский

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Ecology, Evolution and Development

Development Growth & Differentiation, Journal Year: 2018, Volume and Issue: 61(1), P. 3 - 4

Published: Dec. 27, 2018

Developmental programs of living organisms have often been modified in response to environmental changes. Modifications phenotypes can occur through the natural selection genetic variations over many generations. Phenotypic also arise by within-generation developmental responses cues. Such phenotypic plasticity is driven epigenetic modulations gene expression within a single generation, but transgenerational transmission environmentally induced traits another matter. Recent studies provided evidence for inheritance acquired characteristics stimuli various organisms, including plants, worms, flies and mammals (Kishimoto, Uno, Okabe, Nono, & Nishida, 2017; Martienssen, Barkan, Taylor, Freeling, 1990; Seong, Li, Shimizu, Nakamura, Ishii, 2011; Weaver et al., 2004). In addition, there has possible association between changes genomic mutations during evolution. For example, triggers regulate transposable element insertion stress-responsive genes (Hosokawa Kakutani, 2018), chromatin organization contributes, at least part, regional variation substitution, deletion rates genome (Makova Hardison, 2015). These observations led us further pursue evolution involving changes, possibly conditions. this special issue Development, Growth Differentiation, we invited original research review articles from pioneering investigators who study processes wide range aim understand mechanisms such under Phenological events as flowering, fruiting growth cessation, are one well-known controlled cues; photoperiod temperature two major cues responses. Kudo (2019) describes importance “a phase lag” these signals seasonal plasticity. Regarding adaptation speciation Tsuchimatsu colleagues reviews recent integrative using population genomics that covered interactions with other local climatic conditions causes consequences reproductive isolation. Tsukaya Kinoshita summarize current understanding molecular aspects development one-leaf plants Gesneriaceae family (eudicots), which lack typical shoot apical meristem, discuss scenario how peculiar process evolved. Then, goal elucidating animal multicellularity revealing contents unicellular horozoans (the closest relatives animals), Suga describe new mate-pair information-based strategy improve quality draft assemblies on smaller scale. Kuo Lai Clitellata, include oligochaete worms leeches, leading unique morphological features leeches. The peripheral nervous system, cooperation central allows animals adjust their physiology behaviors internal external environment. Liu findings molecular, cellular system bilaterians, its evolutionary history. Ando Niimi historical background color patterns Asian multicolored ladybird beetle, Harmonia axyridis—from results classic findings—and pattern formation insects, development, evolution, ecology. Miura examines role juvenile hormone taxonomic groups, insects daphnids. Evolution complex appendicular muscular systems amniotes them develop sophisticated behavioral locomotive environments. We, Okamoto, Moriyama, Kuraku, Kai, Tanaka (2019), studied migrating muscle precursors, lead emergence limbs amniotes. Kitano, Ishikawa, Kusakabe parallelism transcriptomes marine stream ecotypes threespine stickleback geologically distinct regions show cis-regulatory main sources parallel transcriptome system. Koshiba-Takeuchi vertebrates alter morphologies functions circulatory according Finally, Chuong related modulation feather sex hormone-dependent morpho-regulatory modules. We hope provide opportunity integrated discussion incentive exploration On behalf Japanese Society Biology, editors would like thank all contributors issue.

Language: Английский

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Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 3, 2023

The transition from natal downs for heat conservation to juvenile feathers simple flight is a remarkable environmental adaptation process in avian evolution. However, the underlying epigenetic mechanism this primary feather mostly unknown. Here we conducted time-ordered gene co-expression network construction, analysis, and functional perturbations developing follicles elucidate four downy-juvenile events. We discovered that LEF1 works as key hub of Wnt signaling build rachis converts radial downy bilateral symmetry. Extracellular matrix reorganization leads peripheral pulp formation, which mediates epithelial - mesenchymal interactions branching morphogenesis. ACTA2 compartments dermal papilla stem cells cycling. Novel usage scale keratins strengthens sheath with SOX14 regulator. found largely conserved chicken (precocious) zebra finch (altricial) discussed possibility evolutionary started feathered dinosaurs.

Language: Английский

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