International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1584 - 1584

Published: Feb. 13, 2025

Cardiovascular diseases (CVD) are the primary cause of mortality globally. A significant aspect CVD involves their association with aging and susceptibility to neonatal programming. These factors suggest that adverse conditions during development can disrupt cardiomyocyte differentiation, thereby leading heart dysfunction. This study focuses on long-term effects inflammatory oxidative stress due lactose intolerance (NLI) transcriptome phenotype. Our recent bioinformatic focused toggle genes indicated NLI correlates switch off some in thyroid hormone, calcium, antioxidant signaling pathways, alongside switch-on/off involved DNA damage response inflammation. In presented study, we evaluated ploidy different regions left ventricle (LV), complemented by a transcriptomic analysis quantitative (gradual) difference expression. Cytophotometric morphologic analyses LV cardiomyocytes identified hyperpolyploidy bridges between nuclei suggesting telomere fusion. Transcriptomic profiling highlighted damage, aging, chromatin decompaction, along suppression pathways governing muscle contraction energy metabolism. Echocardiography revealed statistically dilation decrease ejection fraction. The estimation survival rates shortened median lifespan approximately 18% (p < 0.0001) compared control. Altogether, these findings may increase cardiovascular accelerating increased hyperpolyploidization reduced cardiac contractile function. Collectively, our data emphasize importance early identification management metabolic stressors, such as NLI, mitigate risks.

Language: Английский