Cancer Cell,
Journal Year:
2023,
Volume and Issue:
41(9), P. 1586 - 1605.e15
Published: Aug. 10, 2023
We
characterized
a
prospective
endometrial
carcinoma
(EC)
cohort
containing
138
tumors
and
20
enriched
normal
tissues
using
10
different
omics
platforms.
Targeted
quantitation
of
two
peptides
can
predict
antigen
processing
presentation
machinery
activity,
may
inform
patient
selection
for
immunotherapy.
Association
analysis
between
MYC
activity
metformin
treatment
in
both
patients
cell
lines
suggests
potential
role
non-diabetic
with
elevated
activity.
PIK3R1
in-frame
indels
are
associated
AKT
phosphorylation
increased
sensitivity
to
inhibitors.
CTNNB1
hotspot
mutations
concentrated
near
sites
mediating
pS45-induced
degradation
β-catenin,
which
render
Wnt-FZD
antagonists
ineffective.
Deep
learning
accurately
predicts
EC
subtypes
from
histopathology
images,
be
useful
rapid
diagnosis.
Overall,
this
study
identified
molecular
imaging
markers
that
further
investigated
guide
stratification
more
precise
EC.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1264 - 1264
Published: Jan. 23, 2022
Metformin
is
the
most
commonly
used
treatment
to
increase
insulin
sensitivity
in
insulin-resistant
(IR)
conditions
such
as
diabetes,
prediabetes,
polycystic
ovary
syndrome,
and
obesity.
There
a
well-documented
correlation
between
glucose
transporter
4
(GLUT4)
expression
level
of
IR.
Therefore,
observed
peripheral
utilization
after
metformin
likely
comes
from
induction
GLUT4
its
increased
translocation
plasma
membrane.
However,
mechanisms
behind
this
effect
critical
targets
are
still
largely
undefined.
The
present
review
explores
evidence
for
crucial
role
changes
activation
signaling
pathway
mediators,
AMPK,
several
posttranscriptional
modifications
based
on
previously
published
preclinical
clinical
models
metformin's
mode
action
animal
human
studies.
Our
aim
provide
comprehensive
studies
field
order
shed
some
light
complex
interactions
action,
expression,
translocation,
sensitivity.
Natural Products and Bioprospecting,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: May 9, 2022
Abstract
Human
longevity
has
increased
dramatically
during
the
past
century.
More
than
20%
of
9
billion
population
world
will
exceed
age
60
in
2050.
Since
last
three
decades,
some
interventions
and
many
preclinical
studies
have
been
found
to
show
slowing
aging
increasing
healthy
lifespan
organisms
from
yeast,
flies,
rodents
nonhuman
primates.
The
are
classified
into
two
groups:
lifestyle
modifications
pharmacological/genetic
manipulations.
Some
genetic
pathways
characterized
a
specific
role
controlling
lifespan.
Thus,
all
genes
potential
antiaging
targets.
Currently,
compounds
target
calorie-restriction
mimetic,
autophagy
induction,
putative
enhancement
cell
regeneration,
epigenetic
modulation
gene
activity
such
as
inhibition
histone
deacetylases
DNA
methyltransferases,
under
development.
It
appears
evident
that
exploration
new
targets
for
these
agents
based
on
biogerontological
research
provides
an
incredible
opportunity
healthcare
pharmaceutical
industries.
present
review
focus
properties
slow
life
span
extension
natural
products
various
biological
resources,
endogenous
substances,
drugs,
synthetic
compounds,
well
mechanisms
evaluation.
These
bioactive
could
benefit
discussed.
