The association between sarcopenic obesity, sarcopenia and functional dependence, malnutrition, and mortality: the phenomenon of obesity paradox in sarcopenic obesity

European Geriatric Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

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Association between physical activity and frailty transitions in middle-aged and older adults: a nationwide longitudinal study

International Journal of Behavioral Nutrition and Physical Activity, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 10, 2025

Abstract Background Frailty has become an important health problem in the middle-aged and older people population. Physical activity (PA) is a key intervention for frailty prevention management. However, studies of association between COVID-19 pre-pandemic PA worsening or improvement during pandemic remain unclear. Methods This longitudinal cohort study used data from English Longitudinal Study Ageing (ELSA), including participants aged 50 over. Three intensities (vigorous, moderate, mild) were categorized as less than once per week at least week, respectively, based on participant self-report. The index (FI) assessed status, defining FI ≥ 25. Logistic regression was applied to examine frailty, estimating odds ratios (OR) 95% confidence intervals (95% CI). Results Of 4379 non-frail baseline (median age 67, 54.9% female), 8.1% developed mean follow-up 3.5 years. Among 564 frail 71, 66.5% 17.9% regained health. Compared those engaging who engaged vigorous (OR: 0.47 [95% CI: 0.35–0.62]), moderate 0.37 0.29–0.48]), mild 0.38 0.26–0.56]) had lower risk worsening. Additionally, 2.04 1.29–3.21]) 2.93 1.54–5.58]) higher likelihood improvement. Sensitivity analyses comprehensive levels confirmed these findings. Participants maintained one (Vigorous, OR: 0.20 [95%CI: 0.12–0.33]; Moderate, 0.13 0.09–0.19]; Mild, 0.11–0.38]) rates (Moderate, 3.43 1.93–6.11]; 4.65 1.90-11.42]). In addition, individuals 0.35 0.20–0.60]; 0.36 0.22–0.56]) transitioned inactive active also exhibited frailty. Conclusions emphasized critical role preventing improving people, especially pandemic. Our highlighted importance maintaining habits reduce promote its Also, indicated that These findings enriched understanding provided valuable insights addressing impact future pandemics people.

Language: Английский

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Inflammatory markers mediate the association between weight-adjusted waist circumference and mortality in patients with cardiometabolic syndrome

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Cardiometabolic Syndrome (CMS) is associated with increased risks of cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality. The Weight-Adjusted Waist Circumference Index (WWI) has emerged as a novel metric for assessing obesity its health implications. To investigate the relationship between WWI mortality in CMS patients, considering mediating role inflammatory markers. study analyzed National Health Nutrition Examination Survey (NHANES) data from 2003 to 2018 identified 6506 patients CMS. was calculated square root waist circumference (cm) divided by weight (kg). Mortality were correlated Death (NDI). Cox regression models, adjusted demographic clinical covariates, assessed effect on cause-specific Finally, markers explored using mediation analysis. observed positive linear association all-cause, cardiovascular, diabetes-related mortalities among patients. After adjusting confounders, remained significant predictor Mediation analysis revealed that markers, particularly neutrophil systemic immune-inflammation index (SII), significantly mediated an independent inflammation potentially linking risk. These findings may inform risk assessment management strategies

Language: Английский

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Association between dietary patterns and existing natural teeth in Chinese elderly: a national community-based study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 13, 2025

Objective To promote healthy aging, we aimed to evaluate the independent and joint effects of protein, sugar-salt, anti-inflammatory diets on existing natural teeth among Chinese elderly, further explore mediating role body mass index (BMI). Methods Based 2017–2019 Longitudinal Healthy Longevity Survey (CLHLS), 11,608 participants aged 65 above were recruited in this cross-sectional study. Protein, measured via a simplified 13-item dietary frequency questionnaire (dietary around age 60). Restricted cubic spline multiple linear regression analyses evaluated associations between patterns teeth, mediation analysis explored BMI’s role. Results Protein positively linearly associated with while sugar-salt negatively associated. Compared low (Q1), high protein (Q4) higher number ( β : 1.70, 95%CI: 1.14, 2.25; 1.98, 1.45, 2.51, respectively; 28% 38% risk decreased for fewer than 20 respectively), whereas had lowest −1.14, −1.61, −0.67; 44% increased teeth). We found effect −1.97, 95% CI: −2.61, −1.33). Moreover, BMI mediated 10.88%, 19.69%, 10.74% respectively. Conclusion Promoting reducing intake elderly individuals may reduce tooth loss, possibly partly through overweight or obesity.

Language: Английский

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Association between central obesity and ADL impairment among the middle-aged and elderly population in China based on CHARLS

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

To explore the associations of central obesity indicators including waist circumference (WC), waist-to-height ratio (WHtR), and weight-adjusted index (WWI) with impairment basic activities daily living (BADL) instrumental (IADL) among middle-aged elderly population in China. This prospective study used baseline data from 2011 follow-up data, involving 6440 9646 participants, respectively. Binary logistic regression analysis was to assess relationships. Restricted cubic spline (RCS) curve also analyze correlation trends. Stratified analyses were performed identify potential differences. Receiver operating characteristic curves plotted evaluate predictive value each indicator. WC (OR = 1.01, 95% CI:1.01-1.02), WHtR 1.21, CI 1.09-1.33), WWI 1.10, CI:1.02-1.19) significantly associated BADL impairment. Only 1.16, 95%CI:1.09-1.23) IADL WC, linearly while The risk association between stronger drinking individuals males. In participants a BMI less than 24 kg/m² who had received high school education or above, increase accompanied by more significant ability is higher that WHtR, AUC values 0.597 0.615. WWI, as comprehensive indicator obesity, may be useful comprehensively identifying early activity population.

Language: Английский

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Association Between Cognitive impairment and Comprehensive Weight Phenotypes Among Older Adults In China: A Nationwide Survey

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Objective To investigate the relationship between obesity and cognitive impairment among older adults using body mass index (BMI) weight-adjusted waist circumference (WWI). Methods Drawing on data from Chinese Longitudinal Healthy Longevity Survey database spanning 2011 to 2018, study employed Cox regression analysis restricted cubic spline method examine BMI, WWI, impairment. Results A total of 2546 subjects were included in this study. According lean was a risk factor for (HR = 1.347, 95%CI:1.011 ~ 1.795), overweight 0.446, 95%CI:0.35 0.568) 0.225, 95%CI:0.161 0.314) protective adults. classification high WWI 2.064, 95%CI:1.731 2.461). The showed that when > 11cm/, increased with increase WWI. comprehensive weight phenotype constructed by BMI combined found have highest 1.542, 95%CI:1.087–2.187), low had largest effect function by(HR 0.108, 95%CI: 0.062 0.186). Conclusion Maintaining an appropriate level or even state can contribute preservation health This holds significant importance as it is preventive measure against onset

Language: Английский

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Body mass index, waist circumference, hip circumference, abdominal volume index, and cognitive function in older Chinese people: a nationwide study

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 8, 2024

Numerous studies have indicated an obesity paradox in observational research on aging health, where being normal weight or underweight adversely affects cognitive function, while moderate may offer protective benefits. This study aims to investigate the association between body mass index (BMI), waist circumference (WC), hip (HC), waist-to-height ratio (WHtR), waist-to-hip (WHR), abdominal volume (AVI), and joint effect of BMI HC impairment older Chinese people.

Language: Английский

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