Diuretics: a review of the pharmacology and effects on glucose homeostasis DOI Creative Commons
Mauricio Di Fulvio,

Yakshkumar Dilipbhai Rathod,

S. T. Sheik Abdul Khader

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Thiazides, thiazide-like and loop diuretics are commonly prescribed to manage hypertension heart failure. The main mechanism of action these involve inhibition Na+ reabsorption in the kidneys, leading increased urine production. While effective, diuretics, particularly hydrochlorothiazide, have been linked altered glucose metabolism other metabolic issues. These disruptions fuel homeostasis not clearly related their primary fluid management, raising concerns for patients with syndrome, which high blood pressure coexists obesity, insulin resistance, intolerance dyslipidemia. In this review, we conducted an extensive examination existing literature on classes covering publications from late 1950s present. Our objective was investigate origins, development current understanding widely recognized association between use general potential negative impact homeostasis. We focused clinical experimental evidence most diuretics: chlorthalidone, bumetanide furosemide. On one hand, supports hypothesis that effects primarily little, if any observed diuretics. addition, do appear be diuretic or intended pharmacological targets, about long-term specific vulnerable populations, including those syndrome. using animal models suggest variable secretion metabolism. Although mechanisms involved understood, further research is needed uncover molecular by certain disrupt contribute disturbances.

Language: Английский

Diuretics: a review of the pharmacology and effects on glucose homeostasis DOI Creative Commons
Mauricio Di Fulvio,

Yakshkumar Dilipbhai Rathod,

S. T. Sheik Abdul Khader

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Thiazides, thiazide-like and loop diuretics are commonly prescribed to manage hypertension heart failure. The main mechanism of action these involve inhibition Na+ reabsorption in the kidneys, leading increased urine production. While effective, diuretics, particularly hydrochlorothiazide, have been linked altered glucose metabolism other metabolic issues. These disruptions fuel homeostasis not clearly related their primary fluid management, raising concerns for patients with syndrome, which high blood pressure coexists obesity, insulin resistance, intolerance dyslipidemia. In this review, we conducted an extensive examination existing literature on classes covering publications from late 1950s present. Our objective was investigate origins, development current understanding widely recognized association between use general potential negative impact homeostasis. We focused clinical experimental evidence most diuretics: chlorthalidone, bumetanide furosemide. On one hand, supports hypothesis that effects primarily little, if any observed diuretics. addition, do appear be diuretic or intended pharmacological targets, about long-term specific vulnerable populations, including those syndrome. using animal models suggest variable secretion metabolism. Although mechanisms involved understood, further research is needed uncover molecular by certain disrupt contribute disturbances.

Language: Английский

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