Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers DOI Creative Commons
Laura Bravo, Sara Martínez‐López, José Luis Sierra-Cinos

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects moderate intake yerba nonhabitual A randomized, crossover, controlled was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, lipids, glucose metabolism, inflammatory cytokines, chemokines, different markers endothelial function, as well incretins, adipocytokines, hormones were measured baseline after 8 weeks consuming a decaffeinated isotonic drink (control). After daily consumption three servings tea, colony‐stimulating factors decreased all participants. LDL‐C normocholesterolemic individuals, while control interventions elicited similar hypolipidemic action group. Ghrelin glucose‐dependent insulinotropic polypeptide (GIP) significantly intake, glucagon‐like peptide 1 (GLP‐1) adipocytokines remained unchanged. Body fat percentage tricipital skinfold only subjects, with no on total body weight. In conclusion, could exert protective consumers subjects cardiovascular risk. Trial Registration : This trial retrospectively registered ClinicalTrials (NCT06729905)

Language: Английский

Regulation of GLP-1 and Glucagon Receptor Function by β-Arrestins in Metabolically Important Cell Types DOI
Liu Liu,

Muhammad Rashid,

Jürgen Wess

et al.

Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Glucagon-like peptide-1 (GLP-1) and glucagon (GCG) are polypeptides derived from a common precursor (preproglucagon) that modulates the activity of numerous cell types involved in regulating glucose energy homeostasis. GLP-1 GCG exert their biological functions via binding to specific G protein-coupled receptors (GLP-1Rs GCGRs). Ligand-activated GLP-1Rs GCGRs preferentially activate heterotrimeric protein Gs, resulting increased cytosolic cAMP levels. However, activation two also leads recruitment β-arrestin-1 -2 (βarr1 βarr2, respectively) intracellular surface receptor proteins. The β-arrestins activated contributes termination receptor-stimulated coupling. In addition, receptor-β-arrestin complexes can act as signaling nodes own right by modulating many pathways. this Review, we will discuss roles βarr1 βarr2 key metabolic mediated GCGRs. During past decade, GLP-1R agonists have emerged highly efficacious antidiabetic antiobesity drugs. Moreover, dual stimulate both predicted offer additional therapeutic benefits compared agonist monotherapy. We summarize try synthesize series studies suggesting development protein-biased and/or GCGR agonists, which do not lead β-arrestins, may even more agents.

Language: Английский

Citations

0
Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers DOI Creative Commons
Laura Bravo, Sara Martínez‐López, José Luis Sierra-Cinos

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects moderate intake yerba nonhabitual A randomized, crossover, controlled was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, lipids, glucose metabolism, inflammatory cytokines, chemokines, different markers endothelial function, as well incretins, adipocytokines, hormones were measured baseline after 8 weeks consuming a decaffeinated isotonic drink (control). After daily consumption three servings tea, colony‐stimulating factors decreased all participants. LDL‐C normocholesterolemic individuals, while control interventions elicited similar hypolipidemic action group. Ghrelin glucose‐dependent insulinotropic polypeptide (GIP) significantly intake, glucagon‐like peptide 1 (GLP‐1) adipocytokines remained unchanged. Body fat percentage tricipital skinfold only subjects, with no on total body weight. In conclusion, could exert protective consumers subjects cardiovascular risk. Trial Registration : This trial retrospectively registered ClinicalTrials (NCT06729905)

Language: Английский

Citations

0