The effect of physical exercise during radiotherapy on physical functioning in patients with head and neck cancer: a trial within cohorts, the VITAL study DOI Creative Commons

Yvette Kriellaars,

Jorine Ariane Vermaire,

Maaike Beugeling

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 4, 2023

Abstract Background During the last ten years, twelve studies are published investigating physical exercise interventions (PEIs) for patients with head and neck cancer (HNC) during or after radiotherapy (RT), chemoradiation (CRT) bioradiation (BRT). The overall conclusion is clear, PEIs HNC safe feasible. RT, CRT BRT ((C/B)RT) may maintain improve function quality of life (QoL). It is, however, necessary to do more research underpin these effects. Besides, a cost-effectiveness analysis missing. aim this study determine compare performance, muscle strength, fatigue, QoL, body composition, nutritional status, activity, treatment tolerability (C/B)RT, healthcare related costs in without 10 week intervention (C/B)RT. Methods This based on trial within cohorts (TwiCs) design will contain prospective cohort 112 patients. Half randomly be invited an experimental PEI. Measurements at baseline (M0), 12 weeks (M1), 6 months (M2) (M3). Statistical analyses performed intention-to-treat instrumental variable using SPSS. Discussion first randomized effect PEI Dutch population it A TwiCs used. However, design, estimation can challenging. Trial Registration protocol registered clinicaltrials.gov number NCT05988060.

Language: Английский

Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study DOI
Kaat Van Aperen, An De Groef, Thierry Troosters

et al.

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(2)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Expectations and Experiences of Participating in a Supervised and Home-Based Physical Exercise Intervention in Patients with Head and Neck Cancer during Chemoradiotherapy: A Qualitative Study DOI Creative Commons
Annemieke Kok, Ellen Passchier, Anne M. May

et al.

Current Oncology, Journal Year: 2024, Volume and Issue: 31(2), P. 885 - 899

Published: Feb. 4, 2024

(1) Background: Chemoradiotherapy (CRT) for head and neck cancer (HNC) is associated with severe toxicity resulting in fatigue weight loss, including loss of skeletal muscle mass. Exercise interventions might positively affect physical fitness quality life. Sufficient adherence compliance rates are necessary optimal effects. This study aimed to gain insight into expectations experiences factors influencing adherence, retention HNC patients participating exercise intervention during CRT. (2) Methods: Consecutive participants were invited semi-structured interviews, conducted pre- post-intervention. A deductive approach was used identify themes compliance. (3) Results: Thematic saturation reached after interviewing 14 pre-intervention. Five identified: planning time management, treatment toxicity, motivation exercise, supervision by a physiotherapist. The intensity the schedule important barriers. Facilitators mentioned emotional benefits, social support as well simplicity home-based setting intervention. (4) Conclusions: personalised approach, considering individual facilitators barriers patients, increase reap effects program.

Language: Английский

Citations

3
DECREASING EDEMA WITH PLATYSMA EXERCISES FOLLOWING THIRD MOLAR EXTRACTION SURGERY: A RANDOMIZED CONTROLLED TRIAL DOI
Sevim Beyza Ölmez, Gökhan Yazıcı, Merve Önder

et al.

Complementary Therapies in Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 101963 - 101963

Published: March 1, 2025

Language: Английский

Citations

0
Feasibility of a supervised and home‐based tailored exercise intervention in head and neck cancer patients during chemoradiotherapy DOI Open Access
Annemieke Kok, Ellen Passchier, Anne M. May

et al.

European Journal of Cancer Care, Journal Year: 2022, Volume and Issue: 31(6)

Published: Aug. 11, 2022

Chemoradiotherapy (CRT) for head and neck cancer (HNC) is associated with high toxicity that adversely affects physical functioning, body composition, fatigue, quality of life treatment outcomes. Exercise interventions during might counteract these negative effects. We therefore assessed the feasibility an exercise programme HNC patients CRT.Forty were offered a tailored 10-week endurance resistance training supervised home-based sessions. Feasibility endpoints (1) adherence (main outcome): ≥60% attendance; (2) recruitment: ≥30%; (3) retention rate: ≥85% (4) compliance ≥60%. Physical performance, muscle strength, fatigue pre- post-intervention.Overall was 54%. The recruitment rate 36%, 65%. Compliance to intervention protocol 66%. Statistically significant decreases found in mean grip fat-free mass clinically relevant deteriorations on several domains life, subscales found.We conclude this CRT its current form feasible only minority patients. suggest adaptations improve rates definitive multicentre trial.This study registered at Netherlands Trial Register (NTR7305), 6 June 2018, retrospectively registered.

Language: Английский

Citations

9
The effect of physical exercise during radiotherapy on physical performance in patients with head and neck cancer: a trial within cohorts study protocol, the vital study DOI Creative Commons

Yvette Kriellaars,

Jorine Ariane Vermaire,

Maaike Beugeling

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 1, 2024

Abstract Background During the last decade, twelve studies have been published investigating physical exercise interventions (PEIs) in patients with head and neck cancer (HNC) during radiotherapy (RT), chemoradiation (CRT) or bioradiation (BRT). These showed that these PEIs are safe feasible. However, only two of were randomised clinical trials (RCTs) a satisfying sample size. Thereby, there is no cost-effectiveness study related to PEI RT, CRT BRT ((C/B)RT) for HNC. Therefore, aim this investigate compare performance, muscle strength, fatigue, quality life (QoL), body mass index (BMI), nutritional status, activity, treatment tolerability, health care costs HNC without 10 week (C/B)RT. Methods This study, based on trial within cohorts (TwiCs) design, will contain prospective cohort at least 112 patients. Fifty-six randomly be invited an experimental PEI. consists both resistance endurance exercises optimize QoL, BMI, tolerability Measurements baseline, after 12 weeks, 6 months, months. Statistical analyses performed intention-to-treat instrumental variable analysis. Discussion seeks physical, economic implications With substantial size, attempts strengthen expand knowledge upon In conclusion, dedicated provide additional evidence Trial registration protocol was registered clinicaltrials.gov number NCT05988060 3 August 2023.

Language: Английский

Citations

0
Factors influencing physical activity in individuals with head and neck cancer: a scoping review DOI Creative Commons
Martina Schmocker, Ramona Engst, Markus Wirz

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(7), P. e083852 - e083852

Published: July 1, 2024

Higher physical activity (PA) levels are associated with better quality of life in people head and neck cancer (HNC). Despite this positive association, most individuals these types have a sedentary or low-activity lifestyle. Limited knowledge exists regarding the factors that influence PA group. Therefore, we reviewed mapped available literature on may HNC.

Language: Английский

Citations

0
Effectiveness of Exercise-Based Interventions on Fatigue among Head and Neck Cancer Patients on Radiotherapy: Systematic Review with Meta-Analysis DOI
Shalini G Nayak, Krishna Sharan,

N Ravishankar

et al.

Seminars in Oncology Nursing, Journal Year: 2024, Volume and Issue: unknown, P. 151755 - 151755

Published: Nov. 1, 2024

Language: Английский

Citations

0
Feasibility of individualized home exercise programs for patients with head and neck cancer–study protocol and first results of a multicentre single-arm intervention trial (OSHO #94) DOI Creative Commons
Sabine Felser,

Julia Rogahn,

Änne Glass

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0301304 - e0301304

Published: Aug. 22, 2024

Introduction Patients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions PwHNC are rare. The ‘OSHO #94’ trial investigates the short- medium-term effects individualized home QoL, activity functionality. study includes a feasibility phase (proof concept) order to evaluate acceptance. Here we present protocol as well results. Methods analysis This prospective, multicentre, single-arm intervention ≥18 years age aftercare or palliative care stable remission under immunotherapy. opened January 01, 2021, estimated completion by December 31, 2024. receive an program consisting mobilization, coordination, strengthening stretching exercises. should be carried out at least three times week over 12 weeks 15 30 minutes, supplemented aerobic training two minutes (intervention). Once weekly telephone calls physiotherapist performed. Subsequently, there is 12-week follow-up (FU) without specifications/contact. Outcomes measured before after following FU. Primary outcome (n = 25) was determination dropout rate during termination cut off if more than 30% withdrew premature. primary OSHO (N 53) change global QoL score pre- post-intervention (EORTC QLQ-C30). Secondary outcomes include clinical patient-reported measures, details functional diagnostic data (e.g. level activity, frequency, flexibility, fall risk performance). Results 25 were enrolled onto cohort. Only16% (4/25 patients) did not complete study. Therefore, recruitment continued. adjusted 60) 20% 53, calculated sample size n 42 11) dropout). Conclusions Individualized programs seem feasible. Consequently, aim now short exercise.

Language: Английский

Citations

0
The effect of physical exercise during radiotherapy on physical functioning in patients with head and neck cancer: a trial within cohorts, the VITAL study DOI Creative Commons

Yvette Kriellaars,

Jorine Ariane Vermaire,

Maaike Beugeling

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 4, 2023

Abstract Background During the last ten years, twelve studies are published investigating physical exercise interventions (PEIs) for patients with head and neck cancer (HNC) during or after radiotherapy (RT), chemoradiation (CRT) bioradiation (BRT). The overall conclusion is clear, PEIs HNC safe feasible. RT, CRT BRT ((C/B)RT) may maintain improve function quality of life (QoL). It is, however, necessary to do more research underpin these effects. Besides, a cost-effectiveness analysis missing. aim this study determine compare performance, muscle strength, fatigue, QoL, body composition, nutritional status, activity, treatment tolerability (C/B)RT, healthcare related costs in without 10 week intervention (C/B)RT. Methods This based on trial within cohorts (TwiCs) design will contain prospective cohort 112 patients. Half randomly be invited an experimental PEI. Measurements at baseline (M0), 12 weeks (M1), 6 months (M2) (M3). Statistical analyses performed intention-to-treat instrumental variable using SPSS. Discussion first randomized effect PEI Dutch population it A TwiCs used. However, design, estimation can challenging. Trial Registration protocol registered clinicaltrials.gov number NCT05988060.

Language: Английский

Citations

0