Medicine,
Journal Year:
2024,
Volume and Issue:
103(46), P. e40481 - e40481
Published: Nov. 15, 2024
Childhood
neurodevelopmental
disorders
(NDDs),
including
autism
spectrum
disorder
(ASD),
attention-deficit
hyperactivity
disorder,
and
Tourette
syndrome,
are
a
predominant
cause
of
health-related
disabilities
in
children
adolescents.
Nevertheless,
disease
biomarkers
still
limited.
The
aim
this
study
was
to
evaluate
the
potential,
causal
relationship
between
mitochondrial
DNA
copy
number
(mtDNA-CN),
metabolic
disorders,
childhood
NDDs
using
two-sample
Mendelian
randomization
(MR)
method.
Genetic
associations
with
mtDNA-CN,
lipoprotein
metabolism,
iron
metabolism
were
selected
as
exposures,
genome-wide
association
data
from
ASD,
syndrome
utilized
outcomes.
Results
suggested
that
high
degree
disordered
related
increases
ASD
risk
result
decrease
mtDNA-CN
(disordered
metabolism–mtDNA:
inverse
variance
weighting
β:
−0.03,
95%
confidence
interval:
−0.05
−0.02,
P
=
2.08
×
10
–5
;
mtDNA-CN–ASD:
odds
ratio:
0.83,
0.69–0.99,
.034).
research
findings
implied
can
mediate
potentially
influencing
development
ASD.
potential
impact
results
for
prevention
treatment
warrants
validation
robust
randomized
clinical
trials.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 10, 2024
Abstract
Aim
This
cross-sectional
study
aimed
to
identify
the
characteristic
changes
of
prefrontal
and
motor
areas
during
a
tai
chi
chuan
task
in
patients
with
type
2
diabetes
mellitus
(T2DM)
major
depressive
disorder
(MDD)
using
real-time
functional
near-infrared
spectroscopy
(fNIRS).
Methods
Three
parallel
groups
(T2DM
DD
group,
T2DM
healthy
group)
were
included
study,
who
recruited
from
December
10,
2022,
May
31,
2023.
All
conducted
designed
by
Eprime
3.0,
fNIRS
was
used
monitor
brain
activation,
connectivity
(FC)
lateralization
participants.
Results
Ninety
older
adults
(aged
≥
60)
participated
this
including
30
MDD,
T2DM,
subjects.
The
MDD
group
showed
altered
cerebral
function
compared
groups,
decreased
abnormal
index
left-sided
ratio
areas,
FC
among
supplementary
area,
dorsolateral
cortex.
Conclusions
Patients
which
contributed
our
understanding
neuropathology
depression
patients.
first
confirmed
ability
evaluate
wearable
merits
further
validation
larger
sample
size.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(46), P. e40481 - e40481
Published: Nov. 15, 2024
Childhood
neurodevelopmental
disorders
(NDDs),
including
autism
spectrum
disorder
(ASD),
attention-deficit
hyperactivity
disorder,
and
Tourette
syndrome,
are
a
predominant
cause
of
health-related
disabilities
in
children
adolescents.
Nevertheless,
disease
biomarkers
still
limited.
The
aim
this
study
was
to
evaluate
the
potential,
causal
relationship
between
mitochondrial
DNA
copy
number
(mtDNA-CN),
metabolic
disorders,
childhood
NDDs
using
two-sample
Mendelian
randomization
(MR)
method.
Genetic
associations
with
mtDNA-CN,
lipoprotein
metabolism,
iron
metabolism
were
selected
as
exposures,
genome-wide
association
data
from
ASD,
syndrome
utilized
outcomes.
Results
suggested
that
high
degree
disordered
related
increases
ASD
risk
result
decrease
mtDNA-CN
(disordered
metabolism–mtDNA:
inverse
variance
weighting
β:
−0.03,
95%
confidence
interval:
−0.05
−0.02,
P
=
2.08
×
10
–5
;
mtDNA-CN–ASD:
odds
ratio:
0.83,
0.69–0.99,
.034).
research
findings
implied
can
mediate
potentially
influencing
development
ASD.
potential
impact
results
for
prevention
treatment
warrants
validation
robust
randomized
clinical
trials.
