Direct oral anticoagulants do not affect miR-27a-3p expression, a regulator of coagulation cascade, in atrial fibrillation patients

Journal of Thrombosis and Thrombolysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract miR-27a-3p targets several proteins on the coagulation cascade. The potential effect of direct oral anticoagulants (DOACs) treatment expression and their broader regulative anticoagulation is unknown. Fifty-nine atrial fibrillation patients treated with rivaroxaban ( n = 19), apixaban 27) or dabigatran 13), were included in study. was analyzed at baseline after 7 days DOAC therapy by using a predesigned TaqMan assay. Relative quantitation calculated compared pooled population different sample groups. did not alter (0.80 fold-change, p 0.486, population; 0.839 0.706, rivaroxaban; 0.921 0.800, apixaban; 0.733 0.540, dabigatran). differ between controls bleeding cases (0.833 0.588, baseline). Female had trend towards increased (1.564 0.177) reduced (0.683 0.243) to male patients. Despite regulatory role cascade, DOACs its expression. However, additional studies ethnic groups are necessary fully elucidate effect, if any, Graphical

Language: Английский

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Exploring the microRNA-mitochondrial nexus in hepatocellular carcinoma

Mitochondrion, Journal Year: 2025, Volume and Issue: 84, P. 102045 - 102045

Published: April 24, 2025

Language: Английский

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What is the role of sex and gender in the future of precision cardiology?

European Heart Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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