The Inaccuracy of the Mood Disorder Questionnaire for Bipolar Disorder in a Community Sample: From the “DYMERS” Construct Toward a New Instrument for Detecting Vulnerable Conditions

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3017 - 3017

Published: April 27, 2025

Background/Objectives: The Mood Disorder Questionnaire (MDQ) is a widely used tool for the early detection of Bipolar (BD), yet its diagnostic accuracy remains debated. In particular, MDQ often yields false positives in individuals with anxiety, stress-related, or personality disorders, raising questions about clinical utility. This study aimed primarily to evaluate sensitivity, specificity, and predictive values identifying BD within large, community-based sample using structured interviews. Additionally, we explored construct DYMERS (Dysregulation Mood, Energy, Social Rhythms Syndrome), proposed condition characterized by mood instability, hyperactivation traits, rhythm dysregulation among MDQ-positive without formal psychiatric diagnosis. Methods: A total 4999 adults were surveyed across six Italian regions stratified random sampling method. Psychiatric diagnoses established DSM-IV-TR criteria via Advanced Neuropsychiatric Tools Assessment Schedule (ANTAS). was administered face validated version, positivity cut-off ≥7. exhibited low sensitivity high specificity (0.962; 95% CI: 0.961–0.963). Results: Among 2337 analyzable cases, showed (96.2%) but (42.9%) BD, indicating limited effectiveness as screening tool. terms, this implies that while are unlikely be positives, substantial proportion true cases not identified. Notably, significant subgroup displayed features consistent DYMERS. Conclusions: Our findings confirm value community samples. However, may help identify broader spectrum captured current systems. Future research should focus on validating entity developing targeted instruments capable capturing emerging dimension psychopathology.

Language: Английский

How Do We Actually Make a Diagnosis? Lessons Learned From the Bipolar Action Network

Psychiatric Annals, Journal Year: 2024, Volume and Issue: 54(12)

Published: Dec. 1, 2024

The Bipolar Action Network seeks to address the challenges in diagnosing bipolar disorder by bridging gap between research and clinical practice through a systematic approach. diagnostic method variability contributes errors of omission, such as failing identify hypomanic episodes patients presenting with depression, commission, misinterpreting mood instability symptoms. To improve accuracy, use validated tools is encouraged, including Composite International Diagnostic Interview (CIDI), Mood Disorder Questionnaire (MDQ), or Rapid Screener (RMS), Bipolarity Index Gary Sachs. These provide structured frameworks capture full spectrum disorder. However, integration these instruments into routine faces obstacles, lack accessibility within electronic medical records additional workload for clinicians. adopts collaborative learning health network model, engaging patients, families, clinicians co-develop solutions. also prioritizes simplicity its early phases, beginning user-friendly tool Clinical Global Impression Scale–Severity Disorder. Practical concerns, comorbid conditions, minimizing patient burden, streamlining workflows, remain central ongoing efforts. [ Psychiatr Ann . 2024;54(12):e335–e339.]

Language: Английский