Social hierarchy position in female mice is associated with plasma corticosterone levels and hypothalamic gene expression

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: May 13, 2019

Abstract Social hierarchies emerge when animals compete for access to resources such as food, mates or physical space. Wild and laboratory male mice have been shown develop linear hierarchies, however, less is known regarding whether female sufficient intrasexual competition establish significant social dominance relationships. In this study, we examined groups of outbred CD-1 virgin housed in a large vivaria formed hierarchies. We show that females use fighting, chasing mounting behaviors rapidly highly directionally consistent Notably, these are linear, steep despotic compared Female estrus state was not found effect on aggressive behavior, though dominant had elongated cycles (due increased time estrus) subordinate females. Plasma estradiol levels were equivalent between Subordinate significantly higher basal corticosterone Analyses gene expression the ventromedial hypothalamus indicated elevated ERα, ERβ OTR mRNA This study provides methodological framework neuroendocrine basis aggression mice.

Language: Английский

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Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 273 - 294

Published: March 22, 2022

Recent advances in fluorescence imaging permit large-scale recording of neural activity and dynamics neurochemical release with unprecedented resolution behaving animals. Calcium highly optimized genetically encoded indicators provides a mesoscopic view from defined populations at cellular subcellular resolutions. Rigorously improved voltage sensors microscopy allow for robust spike populational neurons various brain regions. In addition, recent protein engineering efforts the past few years have led to development neurotransmitters neuromodulators. Here, we discuss applications these fluorescent reporting response behaviors different biological systems as well drug discovery. We also report simple model guide sensor selection optimization.

Language: Английский

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Neural systems that facilitate the representation of social rank

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 377(1845)

Published: Jan. 10, 2022

Across species, animals organize into social dominance hierarchies that serve to decrease aggression and facilitate survival of the group. Neuroscientists have adopted several model organisms study in laboratory setting, including fish, reptiles, rodents primates. We review recent literature across species sheds light onto how brain represents rank guide socially appropriate behaviour within a hierarchy. First, we discuss responds status signals. Then, approach avoidance learning mechanisms propose could drive rank-appropriate behaviour. Lastly, memories individuals (social memory) this may support maintenance unique individual relationships This article is part theme issue ‘The centennial pecking order: current state future prospects for hierarchies’.

Language: Английский

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Prevalence of and risk factors for depressive and anxiety symptoms in a large sample of Chinese adolescents in the post-COVID-19 era

Child and Adolescent Psychiatry and Mental Health, Journal Year: 2021, Volume and Issue: 15(1)

Published: Dec. 1, 2021

Depressive and anxiety symptoms are widespread among adolescents today, creating a large social problem. However, few previous studies have addressed depression in Chinese cohorts. The aim of this study was to evaluate the prevalence risk factors for depressive middle school adolescent students post-COVID-19 era.A total 22,380 from Jiangsu Province were surveyed online, their general demographic data collected. Patient Health Questionnaire-9 (PHQ-9) used assess symptoms, seven-item Generalized Anxiety Disorder (GAD-7) scale measure symptoms.Of these participants (aged 12-17 years), 25.6% had 26.9% 20.6% combination symptoms. higher female (27.6%) than male (23.7%; χ2 = 45.479, P 0.000), proportion with (28.6%) (25.4%; 29.390, 0.000). Furthermore, binary logistic regression analysis showed that gender, region, parental relationship significantly associated adolescents, while age, symptoms.Our findings demonstrated reported high. Female urban poor may be policy makers, schools, families need pay more attention psychological health develop response plans take early intervention measures reduce anxiety.

Language: Английский

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Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults

General Psychiatry, Journal Year: 2021, Volume and Issue: 34(4), P. e100411 - e100411

Published: Aug. 1, 2021

Adolescence is the peak period for incidence of anxiety disorders. Recent findings have revealed immaturity neural networks underlying emotional regulation in this population. Brain vulnerability to adolescence related unsynchronised development anxiety-relevant brain functional systems. However, our current knowledge on deficits adolescent mainly borrowed from studies adults. Understanding adolescent-specific essential developing biomarkers and brain-based therapies targeting anxiety. This article reviews compares recent neuroimaging literature anxiety-related structural between adult populations, proposes a model highlighting differences adulthood networks. emphasises that control system tends be hypoactivated, fear conditioning immature, reward stress response systems are hypersensitive. Furthermore, striatum’s links amygdala prefrontal cortex strengthened, while link weakened adolescence. helps explain why adolescents vulnerable disorders provides insights into potential approaches intervene

Language: Английский

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Oxytocin–Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice

Endocrinology, Journal Year: 2017, Volume and Issue: 159(2), P. 763 - 775

Published: Nov. 24, 2017

Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics (i.e., social defeat stress) evokes a species-specific posture via unknown mechanisms. Oxytocin neurons have been shown be activated by stressful stimuli and prosocial anxiolytic actions. The roles of oxytocin during remain unclear. Expression c-Fos, marker neuronal activation, in receptor‒expressing was investigated mice. projection examined with an anterograde viral tracer, which induces selective expression membrane-targeted palmitoylated green fluorescent protein neurons. Defensive behaviors double receptor‒deficient mice were analyzed. After stress, c-Fos increased the bed nucleus stria terminalis, supraoptic nucleus, paraventricular hypothalamic nucleus. also brain regions, including ventrolateral part ventromedial hypothalamus periaqueductal gray. Projecting fibers from found showed reduced second stress. These findings suggest that activates oxytocin–oxytocin receptor systems, are consistent view activation gray, facilitates posture.

Language: Английский

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Controllable stress elicits circuit-specific patterns of prefrontal plasticity in males, but not females

Brain Structure and Function, Journal Year: 2019, Volume and Issue: 224(5), P. 1831 - 1843

Published: April 26, 2019

Language: Английский

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The Interplay Between Adolescent Friendship Quality and Resilient Functioning Following Childhood and Adolescent Adversity

Adversity and Resilience Science, Journal Year: 2020, Volume and Issue: 2(1), P. 37 - 50

Published: Nov. 16, 2020

Abstract Child and adolescent adversity (‘CA’) is a major predictor of mental health problems in adolescence early adulthood. However, not all young people who have experienced CA develop psychopathology; their functioning can be described as resilient . We previously found that following facilitated by friendships. during adolescence, friendships undergo significant change. It unknown whether after fluctuates with these normative changes friendship quality. used Latent Change Score Modelling large sample adolescents (i.e. the ROOTS cohort; N = 1238) to examine how emergent quality at ages 14 17 inter-relate change together. had strong associations age 14, although did predict higher 17. Higher 14-year-olds history was associated positive from Finally, improvements went hand-in-hand, even when taking into account baseline levels both, within or over time, association between time. show together Our results suggest improving this timeframe may benefit vulnerable group, should tested future research.

Language: Английский

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Sexual differentiation of neural mechanisms of stress sensitivity during puberty

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(43)

Published: Oct. 17, 2023

Anxiety disorders are a major public health concern and current treatments inadequate for many individuals. is more common in women than men this difference arises during puberty. Sex differences physiological stress responses may contribute to variability. During puberty, gonadal hormones shape brain structure function, but the extent which these changes affect sensitivity unknown. We examined how pubertal androgens behavioral neural social California mice ( Peromyscus californicus ), model species studying sex responses. In adults, defeat reduces approach increases vigilance females not males. show absent juveniles, that prepubertal castration sensitizes adult males defeat. Adult gonadectomy does alter defeat, indicating act puberty program adulthood. Calcium imaging medioventral bed nucleus of stria terminalis (BNST) showed threats increased activity generalized less threatening contexts. These results support recent hypotheses BNST responds immediate threats. Prepubertal treatment with nonaromatizable androgen dihydrotestosterone acts reduce effects on adults. data indicate activation receptors critical programming

Language: Английский

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Leveraging the unique social organization of California mice to study circuit-specific effects of oxytocin on behavior

Hormones and Behavior, Journal Year: 2024, Volume and Issue: 160, P. 105487 - 105487

Published: Jan. 27, 2024

Language: Английский

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