Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(1), P. 437 - 448
Published: Jan. 2, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
Increasing
evidence
suggests
higher
incidence
of
depression
in
IBD
patients
compared
with
the
general
population,
but
underlying
mechanism
remains
uncertain.
Rattan
pepper
polysaccharide
(RPP)
an
important
active
ingredient
rattan
pepper,
yet
its
effects
mechanisms
on
intestinal
inflammation
depression-like
behavior
remain
largely
unknown.
This
study
aims
to
investigate
ameliorating
effect
RPP
dextran
sulfate
sodium
salt
(DSS)-induced
as
well
reveal
mechanism.
Our
results
indicate
that
effectively
ameliorated
microbiota
imbalance
metabolic
disorders
short-chain
fatty
acids
(SCFAs)
bile
mice
DSS-induced
inflammation,
contributing
recovery
Th17/Treg
homeostasis.
Importantly,
alleviated
brain
caused
by
inflammatory
factors
entering
through
blood–brain
barrier.
may
be
attributed
inhibition
TLR4/NF-κB
signaling
pathway,
which
alleviates
neuroinflammation,
activation
CREB/BDNF
improves
synaptic
dysfunction.
Therefore,
our
findings
suggest
play
role
alleviating
gut
microbiota–gut–brain
axis.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(8), P. 104881 - 104881
Published: April 11, 2023
Lifestyle
is
an
important
factor
in
health,
and
researchers
are
trying
to
see
the
adverse
effect
on
human
health
of
a
change
lifestyle.
Many
people
follow
unhealthy
lifestyles,
which
affect
physical
mental
health.
Millions
suffer
from
various
problems
like
cardiovascular
disease,
overweight,
malnutrition,
hypertension,
stress,
violence,
etc.
There
many
medicines
that
can
cure
these
diseases,
but
they
have
side
effects.
When
man
consumes
green
leaves
vegetables
his
diet,
chances
reducing
risk
any
disease
increase.
Every
plant
has
primary
secondary
metabolites.
Flavonoid
metabolite
found
plants
plays
role
survival
by
performing
physiological
activities
being
able
withstand
effects
environment.
Quercetin
one
such
bioflavonoid
plants,
onions,
citrus
fruits,
parsley,
It
comes
under
category
flavone,
with
five
hydroxy
groups
chromen-4-one
skeletal
structure.
applications,
include
anti-cancer,
anti-bacterial,
anti-viral,
anti-inflammatory,
anti-diabetic,
However,
use
quercetin
limited
due
its
poor
bioavailability,
aqueous
solubility,
lower
stability
gastrointestinal
tract,
first-pass
effect.
To
enhance
application
quercetin,
derivatives
metal
complex
required
water
soluble,
helps
them
reach
target
site
without
provides
stability.
This
review
divided
into
three
main
sections:
The
first
section
explains
about
flavonoids
their
types;
second
methods
synthesis,
derivatives,
complex;
last
represents
complete
applications
drawbacks
how
overcome
or
deal
drawbacks.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(2), P. 411 - 411
Published: Feb. 19, 2024
Changes
in
the
gut
microbiome
can
affect
cognitive
and
psychological
functions
via
microbiota-gut-brain
(MGB)
axis.
Probiotic
supplements
are
thought
to
have
largely
positive
effects
on
mental
health
when
taken
sufficient
amounts;
however,
despite
extensive
research
having
been
conducted,
there
is
a
lack
of
consistent
findings
probiotics
anxiety
depression
associated
alterations.
The
aim
our
study
systematically
review
most
recent
literature
last
10
years
order
clarify
whether
could
actually
improve
symptoms.
Our
results
indicate
that
majority
suggests
beneficial
role
treatment
anxiety,
existence
substantial
number
less
findings.
Given
probiotics'
potential
offer
novel,
personalized
options
for
mood
disorders,
further,
better
targeted
psychiatric
populations
needed
address
concerns
about
exact
mechanisms
probiotics,
dosing,
timing
treatment,
possible
differences
outcomes
depending
severity
depression.
Brain Research Bulletin,
Journal Year:
2024,
Volume and Issue:
216, P. 111056 - 111056
Published: Aug. 24, 2024
The
intricate
interplay
existing
between
gut
microbiota
and
homeostasis
extends
to
the
realm
of
brain,
where
emerging
research
underscores
significant
impact
on
mood
regulation
overall
neurological
well-being
vice-versa,
with
inflammation
playing
a
pivotal
role
in
mediating
these
complex
interactions.
This
comprehensive
review
explores
inflammation,
alterations
microbiota,
their
major
depressive
disorder
(MDD).
It
provides
cohesive
framework
for
puzzle
pieces
this
triad,
emphasizing
recent
advancements
understanding
inflammatory
states'
contribution
features.
Two
directions
communication
brain
depression
are
discussed,
serving
as
potential
modulator.
Therapeutic
implications
were
discussed
well,
drawing
insights
from
interventional
studies
effects
probiotics
bacterial
composition
symptoms.
Ultimately,
will
attempt
provide
complete
valuable
future
therapeutic
interventions
MDD.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(1), P. 437 - 448
Published: Jan. 2, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
Increasing
evidence
suggests
higher
incidence
of
depression
in
IBD
patients
compared
with
the
general
population,
but
underlying
mechanism
remains
uncertain.
Rattan
pepper
polysaccharide
(RPP)
an
important
active
ingredient
rattan
pepper,
yet
its
effects
mechanisms
on
intestinal
inflammation
depression-like
behavior
remain
largely
unknown.
This
study
aims
to
investigate
ameliorating
effect
RPP
dextran
sulfate
sodium
salt
(DSS)-induced
as
well
reveal
mechanism.
Our
results
indicate
that
effectively
ameliorated
microbiota
imbalance
metabolic
disorders
short-chain
fatty
acids
(SCFAs)
bile
mice
DSS-induced
inflammation,
contributing
recovery
Th17/Treg
homeostasis.
Importantly,
alleviated
brain
caused
by
inflammatory
factors
entering
through
blood–brain
barrier.
may
be
attributed
inhibition
TLR4/NF-κB
signaling
pathway,
which
alleviates
neuroinflammation,
activation
CREB/BDNF
improves
synaptic
dysfunction.
Therefore,
our
findings
suggest
play
role
alleviating
gut
microbiota–gut–brain
axis.
