Expression and function of nicotinic acetylcholine receptors in specific neuronal populations: Focus on striatal and prefrontal circuits

Pharmacological Research, Journal Year: 2024, Volume and Issue: 204, P. 107190 - 107190

Published: May 3, 2024

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central nervous system and play an important role control of neural functions including neuronal activity, transmitter release synaptic plasticity. Although common subtypes nAChRs abundantly throughout brain, their expression different brain regions by individual types is not homogeneous or incidental. In recent years, several studies have emerged showing that particular specific populations which they major influence on activity local circuits behavior. It has been demonstrated even relatively rare can induce significant changes behavior contribute to pathological processes. Depending identity connectivity nAChRs-expressing populations, activation distinct opposing effects signaling. this review, we will summarize available literature describing nicotinic subunits two crucial regions, striatum prefrontal cortex. The review also briefly discuss non-neuronal, glial cells, as cannot be ignored potential targets nAChRs-modulating drugs. final section options could allow us target a neuronal-type-specific manner, only experimental field, but eventually clinical practice.

Language: Английский

---

Mechanisms of Antiparkinsonian Anticholinergic Therapy Revisited

Neuroscience, Journal Year: 2021, Volume and Issue: 467, P. 201 - 217

Published: May 25, 2021

Language: Английский

---

Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2022, Volume and Issue: 43(4), P. 481 - 498

Published: Nov. 30, 2022

Functional magnetic resonance imaging (fMRI) is widely used by researchers to noninvasively monitor brain-wide activity. The traditional assumption of a uniform relationship between neuronal and hemodynamic activity throughout the brain has been increasingly challenged. This now believed be impacted heterogeneously distributed cell types neurochemical signaling. To date, most cell-type- neurotransmitter-specific influences on hemodynamics have examined within cortex hippocampus rodent models, where glutamatergic signaling prominent. However, are relatively unknown in largely GABAergic regions such as caudate putamen (CPu). Given extensive contribution CPu function dysfunction behavior, increasing focus this region fMRI studies, improved understanding could broad impacts. Here we discuss existing findings contributions they may relate with special consideration for how these originate from various circuits. We hope review can help inform direction future studies well interpretation CPu.

Language: Английский

---

Electrophysiological insights into deep brain stimulation of the network disorder dystonia

Pflügers Archiv - European Journal of Physiology, Journal Year: 2023, Volume and Issue: 475(10), P. 1133 - 1147

Published: Aug. 2, 2023

Abstract Deep brain stimulation (DBS), a treatment for modulating the abnormal central neuronal circuitry, has become standard of care nowadays and is sometimes only option to reduce symptoms movement disorders such as dystonia. However, on one hand, there are still open questions regarding pathomechanisms dystonia and, other mechanisms DBS circuitry. That lack knowledge limits therapeutic effect makes it hard predict outcome individual patients. Finding electrophysiological biomarkers seems be promising enable adapted individualised treatment. biomarker search studies cannot conducted patients large scale experimental approaches with animal models needed. In this review, physiological findings deep in humans summarised current pathophysiological concepts discussed.

Language: Английский

---

Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin release factor and estrogen regulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 14, 2024

Cholinergic interneurons (ChIs) act as master regulators of striatal output, finely tuning neurotransmission to control motivated behaviors. ChIs are a cellular target many peptide and hormonal neuromodulators, including corticotropin releasing factor, opioids, insulin leptin, which can influence an animal's behavior by signaling stress, pleasure, pain nutritional status. However, little is known about how sex hormones via estrogen receptors the function these other neuromodulators. Here, we performed in situ hybridization on mouse tissue characterize effect choline acetyltransferase (

Language: Английский

---