Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

Inflammatory processes have been implicated in the pathophysiology of depression. In human studies, inflammation has shown to act as a critical disease modifier, promoting susceptibility depression and modulating specific endophenotypes However, there is scant documentation how inflammatory are associated with neural activity patients We therefore tested hypothesis that peripheral markers IL-6 TNF-α correlate resting state network functional connectivity using magnetic resonance imaging (fMRI) compared it healthy controls. used fMRI investigate (FC) Default Mode Network (DMN) Salience/Ventral Attention (SAL) their association 25 24 subjects. Results this study revealed both DMN SAL networks differentially distinct immunological pathways depending on whether person depressive phenotype or healthy. While FC correlated concentration cytokine subjects, FC's TNF-α's concentration. This highlights importance suggests modulatory effect

Language: Английский

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Navigating the Post-COVID-19 Immunological Era: Understanding Long COVID-19 and Immune Response

Life, Journal Year: 2023, Volume and Issue: 13(11), P. 2121 - 2121

Published: Oct. 26, 2023

The COVID-19 pandemic has affected the world unprecedentedly, with both positive and negative impacts. significantly impacted immune system, understanding immunological consequences of is essential for developing effective treatment strategies. purpose this review to comprehensively explore provide insights into aspects long COVID-19, a phenomenon where individuals continue experience range symptoms complications, even after acute phase infection subsided. system responds initial by producing various cells molecules, including antibodies, T cells, cytokines. However, in some patients, response becomes dysregulated, leading chronic inflammation persistent symptoms. Long encompasses diverse affecting multiple organ systems, respiratory, cardiovascular, neurological, gastrointestinal systems. In post-COVID-19 era, its impact on have become significant concern. Post-COVID-19 pathology, autoimmunity immune-mediated disorders, also been reported patients. This provides an overview current relationship responses, pathology patient outcomes. Additionally, addresses potential treatments immunomodulatory therapies, rehabilitation programs, mental health support, all which aim improve quality life COVID-19. Understanding complex interplay between crucial targeted therapeutic strategies providing optimal care era.

Language: Английский

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Omega-3 Fatty Acids and Neuroinflammation in Depression: Targeting Damage-Associated Molecular Patterns and Neural Biomarkers

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1791 - 1791

Published: Oct. 29, 2024

Major Depressive Disorder (MDD) is a prevalent mental health condition with complex pathophysiology involving neuroinflammation, neurodegeneration, and disruptions in neuronal glial cell function. Microglia, the innate immune cells of central nervous system, release inflammatory cytokines response to pathological changes associated MDD. Damage-associated molecular patterns (DAMPs) act as alarms, triggering microglial activation subsequent cytokine release. This review examines cellular mechanisms underlying MDD pathophysiology, focusing on lipid-mediated modulation neuroinflammation. We explore intricate roles microglia astrocytes propagating cascades discuss how these processes affect integrity at level. Central our analysis are three key molecules: High Mobility Group Box 1 (HMGB1) S100 Calcium Binding Protein β (S100β) alarmins, Neuron-Specific Enolase (NSE) an indicator stress. present evidence from vitro ex vivo studies demonstrating molecules reflect contribute neuroinflammatory milieu characteristic The then explores potential omega-3 polyunsaturated fatty acids (ω-3 PUFAs) neuroinflammation modulators, examining their effects activation, production, resilience models depression. critically analyze experimental data ω-3 PUFA supplementation influences expression HMGB1, S100β, NSE cultures. By integrating findings lipidomic neurobiology, this aims elucidate by which PUFAs may exert antidepressant through markers. These insights understanding neuroprotection inform development targeted, lipid-based therapies for both depression neurodegenerative disorders.

Language: Английский

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High baseline plasma anthranilic acid predicts remission upon acute-series ketamine infusion for treatment-resistant depression

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100503 - 100503

Published: April 1, 2025

Language: Английский

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Mental Health Sequelae of Cardiac Events: A Comprehensive Review of Biological Mechanisms, Prevalence, and Interdisciplinary Care Approaches

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Cardiovascular diseases are the leading cause of mortality worldwide, with postcardiac events such as myocardial infarction, acute coronary syndrome, and sudden cardiac arrest causing significant physiological trauma psychological effects. This study explores complex interplay between mental health disorders, focusing on biological pathways that connect these conditions in at-risk populations. The stress response following a event involves activation sympathetic nervous system hypothalamic-pituitary-adrenal axis, to release hormones inflammatory cytokines. Prolonged systems can result neurotransmitter imbalances, neuroinflammation, epigenetic modifications, increasing susceptibility disorders depression, anxiety, posttraumatic disorder (PTSD). Women exhibit higher vulnerability due hormonal fluctuations more pronounced response. prevalence is substantial, PTSD rates being particularly high among survivors infarction out-of-hospital arrest. These associated poor physical recovery, reduced quality life, an increased risk recurrent mortality. Resilience adaptive coping mechanisms serve protective factors, highlighting importance integrating care within rehabilitation programs. emphasizes need for early detection, targeted interventions, interdisciplinary approach improve outcomes patients recovering from incidents. Understanding psychiatric sequelae crucial cardiologists, management postmyocardial patients, ischemic attack survivors, individuals undergoing open-heart surgery. Early detection interventions long-term outcomes.

Language: Английский

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Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 110903 - 110903

Published: Sept. 18, 2023

Language: Английский

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Altered IL-3 and lipocalin-2 levels are associated with the pathophysiology of major depressive disorder: a case-control study

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 13, 2023

Abstract Background Major Depressive Disorder (MDD) is a common mental ailment and the primary reason for disability. It manifests severe impact on moods, thoughts, physical health. At present, this disorder has become concern in field of public Alteration neurochemicals thought to be involved pathogenesis many psychiatric disorders. Therefore, we aimed evaluate serum IL-3 lipocalin-2 MDD patients healthy controls (HCs). Method We included total 376 participants study. Among them, 196 were patients, 180 age-sex-matched HCs. recruited from Psychiatry Department Bangabandhu Sheikh Mujib Medical University (BSMMU), but different parts Dhaka. All study evaluated by psychiatrist using DSM-5 criteria. To assess severity depression, used Hamilton depression (Ham-D) rating scale. Serum levels measured commercially available enzyme-linked immune-sorbent assay kits (ELISA kits). Results According study, observed elevated (1,024.73 ± 29.84 pg/mL) reduced (29.019 2.073 ng/mL) compared HCs (911.11 20.55 pg/mL 48.065 3.583 ng/mL, respectively). No associations between patients. Conclusions present findings, alterations lipocalin might associated with MDD. These results support that altered can serve as early risk assessment markers depression. Further interventional studies are recommended better understanding role pathophysiology

Language: Английский

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The Use of MRI and TMS in Treatment-Resistant Depression: Advances in Pediatric Applications

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 194 - 194

Published: Feb. 14, 2025

Treatment-resistant depression (TRD) is a substantial burden for psychiatric care, affecting approximately one-third of patients with major depressive disorder (MDD). Adolescent populations are particularly challenging demographic to treat as early intervention crucial prevent treatment resistance, but options limited. Transcranial magnetic stimulation (TMS) has emerged promising non-invasive option TRD in adults well adolescents, offering hope who have not responded conventional therapies. This review examines the convergence functional resonance imaging (fMRI) tool examine how TMS modulates connectivity adolescents MDD. Such analyses led advances our understanding pathophysiology MDD, TRD, and mechanisms TMS. We this evidence, evaluate methodological approaches, identify critical gaps existing literature, highlighting neuroimaging-guided protocols offer therapeutic avenue adolescent cases where treatments proven ineffective.

Language: Английский

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Mental distress and inflammation in bladder cancer: The nerve makes things less vague

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100995 - 100995

Published: April 1, 2025

Language: Английский

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Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Neuroinflammation has been significantly associated with depression and anxiety, both of which are higher cardiometabolic risk. Systemic inflammation was also commonly described in patients disorders. It is thus unclear whether pro-inflammatory cytokines might mediate the effect between depression, disorders, particularly advanced ages. The multiethnic ≥ 50-year-old study population a subset Health Aging Brain Study: Disparities (HABS-HD). Logistic linear regression adjusted for relevant covariables were used to assess associations. Non-linear models evaluated using restricted cubic splines. Mediation analysis determine role (Tumor Necrosis Factor-alpha (TNF-alpha) Interleukine-6 (IL-6)). Models corrected multiple testing False Discovery Rate (FDR)method. In 2093 included cases, and/or anxiety 62% odds CVD (OR=1.62 [95% CI: 1.22-2.15]), 54% type 2 diabetes (OR=1.54 1.29-1.85]), 26% hypertension (OR=26% 1.07-1.48]), 29% obesity (OR=1.29 1.11-1.51]). Only IL-6 showed significant mediating association (10%, p-value FDR =0.016), (13%, <0.001), (16%, (23%, <0.001). Depression major partly mediated most these is, therefore, crucial recognize neuroinflammation preventive therapeutic management

Language: Английский

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