Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior DOI Creative Commons

Naoya Nishitani,

Yuki Sasaki,

Katsuyuki Kaneda

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract 3,4‐methylenedioxymethamphetamine (MDMA), a commonly abused recreational drug, induces prosocial effects such as increased sociability and empathy. The nucleus accumbens (NAc) has been suggested to play crucial role in these MDMA‐mediated effects. However, the relationship between social behavior NAc neural activity, of MDMA on this relationship, remain unknown. In study, we measured activity using fiber photometry classified behaviors mice at times transient increases during approach test (SAT). We found that transiently onset turning toward sniffing novel SAT, although frequency was relatively low. then examined decreased duration per bout but did not alter or mice. These results suggest does affect increase behaviors.

Language: Английский

The nucleus accumbens in reward and aversion processing: insights and implications DOI Creative Commons
Ying Xu, Yingjie Lin, Ming Yu

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

Citations

8
The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents DOI Creative Commons
Johnathan M. Borland

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105809 - 105809

Published: July 14, 2024

BORLAND, J.M., The effects of different types social interactions on the electrophysiology neurons in nucleus accumbens rodents, NEUROSCI BIOBEH REV 21(1) XXX-XXX, 2024.-Sociality shapes an organisms' life. is a critical brain region for mental health. In following review, physiology synthesized. More specifically, sex behavior, aggression, defeat, pair-bonding, play affiliative interactions, parental behaviors, isolation from and maternal separation measures excitatory synaptic transmission, intracellular signaling factors transcription translation rodent models are reviewed. Similarities differences depending type interaction then discussed. This review improves understanding molecular mechanisms sociality.

Language: Английский

Citations

1
Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice DOI
Christopher R. Pryce, Chenfeng Zhang,

Diana Kúkeľová

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Abstract Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, there currently no established therapies. One potential therapeutic approach is restoration of reward anticipation during appetitive behavior, deficits which co-occur with attenuated nucleus accumbens (NAc) activity, possibly due to NAc inhibition mesolimbic dopamine (DA) signaling. Targeting regulation ventral tegmental area (VTA) DA neuron responsiveness cues could involve either the direct or indirect – via pallidium (VP) pathways. candidate orphan G protein-coupled receptor GPR52, expressed by 2 neurons that project VP. In mouse brain-slice preparations, GPR52 inverse agonist (GPR52-IA) evoked inhibitory postsynaptic currents at NAc-VP neurons, disinhibit VTA neurons. A model chronic social stress leads reduced learning effortful motivation was applied investigate GPR52-IA behavioral effects. Control chronically stressed mice underwent a discriminative test tone-appetitive behavior-sucrose reinforcement: responding learning, these anticipatory behaviors were dose-dependently reinstated GPR52-IA. The same then an operant behavior-tone-sucrose restored it. new cohort, GRABDA-sensor fibre photometry used measure activity test: mice, co-occurred specifically tone signaled reinforcement ameliorated both deficits. These findings: (1) Demonstrate preclinical efficacy agonism for behavior. (2) Suggest GPR52-dependent disinhibition NAc-VP-VTA-NAc circuit, leading increased phasic signaling earned incentive stimuli, account clinically relevant

Language: Английский

Citations

0
Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice DOI Creative Commons
Chenfeng Zhang,

Diana Kúkeľová,

Hannes Sigrist

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 7, 2024

Language: Английский

Citations

0
Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior DOI Creative Commons

Naoya Nishitani,

Yuki Sasaki,

Katsuyuki Kaneda

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract 3,4‐methylenedioxymethamphetamine (MDMA), a commonly abused recreational drug, induces prosocial effects such as increased sociability and empathy. The nucleus accumbens (NAc) has been suggested to play crucial role in these MDMA‐mediated effects. However, the relationship between social behavior NAc neural activity, of MDMA on this relationship, remain unknown. In study, we measured activity using fiber photometry classified behaviors mice at times transient increases during approach test (SAT). We found that transiently onset turning toward sniffing novel SAT, although frequency was relatively low. then examined decreased duration per bout but did not alter or mice. These results suggest does affect increase behaviors.

Language: Английский

Citations

0