Cognitive Assessment in SARS-CoV-2 Patients: A Systematic Review DOI Creative Commons
Bruno Biagianti, Asia Di Liberto, Edoardo Nicolò Aiello

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: July 1, 2022

Background Patients with post-infective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) often show both short- and long-term cognitive deficits within the dysexecutive/inattentive spectrum. However, little is known about which alterations are commonly found in patients recovered from SARS-CoV-2, psychometric tools clinicians should consider when assessing cognition this population. The present work reviewed published studies to provide a critical narrative of neuropsychological (NPs) observed after SARS-CoV-2 infection tests most suited for detecting such sequelae depending on illness severity. Methods This review followed Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) guidelines was pre-registered Prospective Register Reviews (PROSPERO) (CRD42021253079). Observational quantitatively were considered. From 711 retrieved articles, 19 conducted without medical comorbidities included stratified by disease Results majority ( N = 13) adopted first-level tests. frequently administered screeners Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE)—with former more likely detect mild, latter moderate/severe deficits. Among second-level tests, those attention executive functions (EFs) highly represented. Remotely-delivered yielded lower percentages impairment. Overall, domains be impaired EFs, attention, memory. Conclusion can detected NPs testing. Depending test features, likelihood observing vary. Further larger sample sizes needed investigate clinical usefulness tools. primary goal preventative health services early detection intervention emerging

Language: Английский

Changes in cognitive functioning after COVID‐19: A systematic review and meta‐analysis DOI
Lucía Crivelli, Katie Palmer, Ismael Luis Calandri

et al.

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 18(5), P. 1047 - 1066

Published: March 17, 2022

Abstract Introduction We conducted a systematic review and meta‐analysis of the cognitive effects coronavirus disease 2019 (COVID‐19) in adults with no prior history impairment. Methods Searches Medline/Web Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA) guidelines. A Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID‐19 healthy controls was performed. Results Oof 6202 articles, 27 studies 2049 individuals included (mean age = 56.05 years, evaluation time ranged acute phase 7 months post‐infection). Impairment executive functions, attention, memory found post‐COVID‐19 patients. The subgroup 290 showed difference MoCA between patients versus −0.94, 95% confidence interval [CI] −1.59, −0.29; P .0049). Discussion Patients have lower general cognition compared up post‐infection.

Language: Английский

Citations

260
Post-acute sequelae of covid-19 six to 12 months after infection: population based study DOI Creative Commons
Raphael S. Peter, Alexandra Nieters, Hans‐Georg Kräusslich

et al.

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e071050 - e071050

Published: Oct. 13, 2022

Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, risk factors, examine the association with general health working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years confirmed SARS-CoV-2 infection between October 2020 March 2021 notified authorities in four geographically defined regions southern Germany. Participants 50 457 patients were invited participate study, whom 053 (24%) responded 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted covid-19; follow-up time 8.5 months) could be included analyses. Main outcome measures Symptom frequencies (six versus before infection), severity clustering, associations recovery Results The fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% 38.1%) neurocognitive impairment (31.3% (3561/11 361), 30.5% 32.2%) contributed most reduced capacity, but chest symptoms, anxiety/depression, headache/dizziness, pain syndromes also prevalent relevant for some differences according sex age. Considering new at least moderate daily life ≤80% recovered or overall estimate was 28.5% (3289/11 536, 27.7% 29.3%) among participants 6.5% (3289/50 457) infected adult population (assuming that all non-responders had completely recovered). true value is likely these estimates. Conclusions Despite limitation a low response rate possible selection recall biases, this suggests considerable burden self-reported post-acute sequelae, notably impairment, even young middle adults mild substantial impact on Trial registration German registry clinical studies DRKS 00027012.

Language: Английский

Citations

206
Cognitive Impairment After COVID-19—A Review on Objective Test Data DOI Creative Commons

Rania Daroische,

Mathilde Suhr Hemminghyth,

Thomas Hasmo Eilertsen

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: July 29, 2021

The aim was to conduct a review on the literature objective cognitive impairment in patients after COVID-19.

Language: Английский

Citations

166
COVID-19 associated cognitive impairment: A systematic review DOI
José Wagner Leonel Tavares-Júnior, Ana Célia Caetano de Souza,

José W.P. Borges

et al.

Cortex, Journal Year: 2022, Volume and Issue: 152, P. 77 - 97

Published: April 18, 2022

Language: Английский

Citations

140
Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study DOI Open Access
Giordano Cecchetti, Federica Agosta, Elisa Canu

et al.

Journal of Neurology, Journal Year: 2022, Volume and Issue: 269(7), P. 3400 - 3412

Published: March 6, 2022

Language: Английский

Citations

121
ESCMID rapid guidelines for assessment and management of long COVID DOI Creative Commons
Dana Yelin, Charalampos D. Moschopoulos, Ili Margalit

et al.

Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(7), P. 955 - 972

Published: Feb. 17, 2022

Language: Английский

Citations

113
Neurocognitive Profiles in Patients With Persisting Cognitive Symptoms Associated With COVID-19 DOI Open Access
Kamini Krishnan, Ashley Miller,

Katherine Reiter

et al.

Archives of Clinical Neuropsychology, Journal Year: 2022, Volume and Issue: 37(4), P. 729 - 737

Published: Jan. 10, 2022

A subset of individuals with coronavirus disease 2019 (COVID-19) appears to develop persisting cognitive and medical symptoms. Research in the acute stages illness, generally utilizing screening measures or case reports, suggests presence deficits attention executive function. This observational study investigated functioning among persistent complaints about 5.5 months after COVID-19 infection.

Language: Английский

Citations

82
Cognitive impairment in people with previous COVID-19 infection: A scoping review DOI Open Access
Margherita Bertuccelli, Luciana Ciringione, Maria Rubega

et al.

Cortex, Journal Year: 2022, Volume and Issue: 154, P. 212 - 230

Published: June 11, 2022

Language: Английский

Citations

76
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI DOI Creative Commons
Miloš Ajčević,

Katerina Iscra,

Giovanni Furlanis

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 10, 2023

Cognitive impairment is one of the most prevalent symptoms post Severe Acute Respiratory Syndrome COronaVirus 2 (SARS-CoV-2) state, which known as Long COVID. Advanced neuroimaging techniques may contribute to a better understanding pathophysiological brain changes and underlying mechanisms in post-COVID-19 subjects. We aimed at investigating regional cerebral perfusion alterations subjects who reported subjective cognitive after mild SARS-CoV-2 infection, using non-invasive Arterial Spin Labeling (ASL) MRI technique analysis. Using MRI-ASL image processing, we investigated 24 patients (53.0 ± 14.5 years, 15F/9M) with persistent complaints COVID-19 period. Voxelwise region-of-interest analyses were performed identify statistically significant differences blood flow (CBF) maps between patients, age sex matched healthy controls (54.8 9.1 13F/9M). The results showed hypoperfusion widespread network group, predominantly affecting frontal cortex, well parietal temporal identified by non-parametric permutation testing (p < 0.05, FWE-corrected TFCE). areas right hemisphere regions more extensive. These findings support hypothesis large dysfunction post-COVID complaints. nature ASL-MRI method play an important role monitoring prognosis

Language: Английский

Citations

62
Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection DOI Creative Commons
David H. Jiang,

Darius J. Roy,

Brett Gu

et al.

JACC Basic to Translational Science, Journal Year: 2021, Volume and Issue: 6(9-10), P. 796 - 811

Published: Sept. 1, 2021

The vast majority of patients (>99%) with severe acute respiratory syndrome coronavirus 2 survive immediate infection but remain at risk for persistent and/or delayed multisystem. This review published reports through May 31, 2021, found that manifestations postacute sequelae (PASC) affect between 33% and 98% disease 2019 survivors comprise a wide range symptoms complications in the pulmonary, cardiovascular, neurologic, psychiatric, gastrointestinal, renal, endocrine, musculoskeletal systems both adult pediatric populations. Additional are likely to emerge be identified over time. Although data on PASC factors vulnerable populations scarce, evidence points disproportionate impact racial/ethnic minorities, older patients, preexisting conditions, rural residents. Concerted efforts by researchers, health systems, public agencies, payers, governments urgently needed better understand mitigate long-term effects individual population health.

Language: Английский

Citations

69