Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study

Critical Care, Journal Year: 2022, Volume and Issue: 26(1)

Published: July 20, 2022

Abstract Background Cognitive impairment has emerged as a common post-acute sequela of coronavirus disease 2019 (COVID-19). We hypothesised that cognitive exists in patients after COVID-19 and it is most severe admitted to the intensive care unit (ICU). Methods This prospective controlled cohort study 213 participants performed at Helsinki University Hospital Helsinki, Finland, comprised three groups patients—ICU-treated ( n = 72), ward-treated 49), home-isolated 44)—with confirmed between March 13 December 31, 2020, participating comprehensive neuropsychological evaluation six months acute phase. Our included control group with no history 48). Medical demographic data were collected from electronic patient records interviews carried out four Questionnaires filled phase provided information about change functioning observed by close informant, well presence self-reported depressive post-traumatic symptoms. Results The differed (effect size η 2 p 0.065, 0.004) total score, calculated measures domains (attention, executive functions, memory). Both ICU-treated 0.011) 0.005) worse than patients. Among those more 12 years education, attention domain 0.021) or non-COVID controls 0.045); male patients, particular, impaired functions 0.037). Conclusions compared less controls, showed long-term impairment. existed particularly for men, functions. Trial registration number : ClinicalTrials.gov NCT04864938, retrospectively registered February 9, 2021

Language: Английский

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Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Journal of Neural Transmission, Journal Year: 2022, Volume and Issue: 129(9), P. 1119 - 1132

Published: Aug. 29, 2022

Abstract Parkinsonism secondary to viral infections is not an uncommon occurrence and has been brought under the spotlight with spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A variety viruses have described a potential inducing or contributing parkinsonism Parkinson’s disease (PD), although relationship between two remains matter debate originating description encephalitis lethargica in aftermath Spanish flu 1918. While some linked increased risk for development PD, others seem causal link parkinsonism. Here, we review currently available evidence on viral-induced focus pathophysiological mechanisms clinical features. We also as factor developing PD SARS-CoV-2 parkinsonism, which might important implications future research treatments.

Language: Английский

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Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort

Journal of Neurology, Journal Year: 2022, Volume and Issue: 270(3), P. 1215 - 1223

Published: Nov. 23, 2022

Abstract Background A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part the post-COVID-19 syndrome. This study aimed assess neuropsychological profile these patients. Methods Assessment at baseline (three months or more following COVID-19) a monocentric prospective cohort Multidomain tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, general health status administered. Results Of 58 screened, six excluded due possible alternative causes impairment (major neurodegenerative disease). remaining 52 individuals, only one had below-threshold screening result Mini-Mental State Examination, 13 scored below cut-off Montreal Cognitive Assessment. Extended testing revealed neurocognitive disorder (NCD) in 31 (59.6%) participants minor NCD majority cases ( n = 26). In NCD, domains learning/memory executive functions impaired 60.7%, complex attention 51.6%, language 35.5%, perceptual-motor function 29.0%. profiles associated daytime sleepiness but not sleep quality, total status, fatigue. Conclusion Neurocognitive can be confirmed around 60% individuals self-reported syndrome mild course. Notably, cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association profiles. Longitudinal studies are needed further evaluate course clarify pathophysiology.

Language: Английский

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Subjective and Objective Cognitive Impairments in Non-Hospitalized Persons 9 Months after SARS-CoV-2 Infection

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 256 - 256

Published: Jan. 16, 2023

Studies on cognitive problems of persons with mild COVID-19 courses are still lacking. This study aimed to determine the frequency and associated factors subjective objective after in non-hospitalized persons. Study participants were examined at University Hospital Augsburg from 04/11/2020 26/05/2021. The Wechsler Adult Intelligence Scale (WAIS) IV digit span, Stroop Color Word Test (SCWT), Regensburger verbal fluency test (RWT) and, ratings memory concentration applied. Of 372 (mean age 46.8 ± 15.2 years, 54.3% women, median time infection 9.1 months), 24.9% reported 21.9% problems. Overall, 55.6% had least a negative alteration any test. strongest impairments found regarding functions (41.1% alterations, 6.2% distinct impairments) (12.4% 5.4% impairments). SCWT showed alterations no more than 3.0% participants. Level school education, age, depressiveness emerged as significantly related tests. number complaints It is important identify impairment patients early offer them effective interventions.

Language: Английский

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Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

Background Post-acute coronavirus disease 2019 (COVID-19) symptoms occurred in most of the COVID-19 survivors. However, few studies have examined issue whether hospitalization results different post-acute symptom risks. This study aimed to compare potential long-term effects hospitalized and non-hospitalized Methods is designed as a systematic review meta-analysis observational studies. A search six databases was performed for identifying articles published from inception until April 20th, 2022, which compared risk survivors using predesigned strategy included terms SARS-CoV-2 (eg, COVID, , 2019-nCoV ), Syndrome post-COVID, post COVID conditions, chronic symptom, long long-haul sequelae, convalescence persistent ( hospitalized, hospital home-isolated ). The present conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020 statement R software 4.1.3 create forest plots. Q statistics I 2 index were used evaluate heterogeneity this meta-analysis. Results Six Spain, Austria, Switzerland, Canada, USA involving 419 742 included. number ranged 63 431, follow-up data collected through visits four another two an electronic questionnaire, visit telephone, respectively. Significant increase risks dyspnea (OR = 3.18, 95% CI 1.90–5.32), anxiety 3.09, 1.47–6.47), myalgia 2.33, 1.02–5.33), hair loss 2.76, 1.07–7.12) found with outpatients. Conversely, persisting ageusia significantly reduced than patients. Conclusion findings suggested that special attention patient-centered rehabilitation service based on needs survey should be provided who experienced high risk.

Language: Английский

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