Association of Vascular Risk Factors with the Risk of Parkinson's Disease among Stroke Survivors—Population-Based Study DOI Creative Commons
Seo Yeon Yoon, Hyun Im Moon, Jin‐Hyung Jung

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Background Stroke survivors usually have many vascular risk factors (VRFs), and recent studies reported the association of VRFs with cognitive decline among stroke survivors, which are also associated PD risk. Therefore, we aimed to investigate how influenced occurrence in individuals stroke. Methods The Korean National Health Insurance Service database was used. We selected who experienced new-onset (ICD-10: I60-I64) between 2008 2016 followed up until 2019. diagnosed according ICD-10 code G20 rare intractable disease registration V124. Lifestyle were collected using self-reported questionnaires, comorbidities defined based on codes, medication, laboratory anthropometric findings. Cox proportional hazard analyses conducted evaluate incidence survivors. Results Among 284,799 3,274 cases over a median follow-up period 5.04 years. In history stroke, smoking (former smoking, ratio (HR) = 0.80, 95% confidence interval (CI), 0.72–0.88; current HR 0.66, CI, 0.58–0.76) alcohol consumption (moderate drinking, 0.83, 0.75–0.91; heavy 0.74, 0.59–0.94) decreased PD. Physically active had showed reduced trend for ( P 0.0508). As risk, increased diabetes mellitus (P <.001), particularly those duration ≥5 years (HR 1.38, 1.25–1.52). Conclusions Our results suggest that Understanding managing relation is needed management after

Language: Английский

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline DOI Open Access

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Published: Aug. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

15
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions DOI Creative Commons

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

6
Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea DOI Creative Commons
Hea Lim Choi, Jong Hyeon Ahn, Won Hyuk Chang

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(4)

Published: Jan. 2, 2024

Abstract Background and purpose Previous studies have examined the risk of stroke in patients with Parkinson disease (PD), but incidence PD onset among its according to severity poststroke disabilities scarcely been investigated. This study aims determine whether is increased using a retrospective cohort large population‐based database. Methods We used data collected by Korean National Health Insurance Service from 2010 2018 307,361 380,917 sex‐ age‐matched individuals without uncover PD. Cox proportional hazards regression was calculate hazard ratio (HR) 95% confidence interval (CI), compared presence disability. Results During 4.31 years follow‐up, had 1.67 times higher (adjusted HR = 1.67, CI 1.57–1.78). The greater than those disabilities, even after adjustment for multiple covariates 1.72, 1.55–1.91; adjusted 1.66, 1.56–1.77, respectively). Conclusions Our demonstrated an patients. professionals need pay careful attention detecting movement disorders as clues diagnosing

Language: Английский

Citations

6
Development and Validation of a Machine Learning-Based Diagnostic Model for Parkinson's Disease in Community-Dwelling Populations: Evidence from the China Health and Retirement Longitudinal Study (CHARLS) DOI
Hongyang Fan, Sai Li, Xin Guo

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 130, P. 107182 - 107182

Published: Oct. 30, 2024

Language: Английский

Citations

2
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea DOI Creative Commons
Hea Lim Choi,

Su Min Jeong,

Keun Hye Jeon

et al.

Breast Cancer Research, Journal Year: 2024, Volume and Issue: 26(1)

Published: Dec. 27, 2024

Depression among breast cancer survivors is a significant concern affecting their long-term survivorship and quality of life. This study investigates the incidence depression identifies associated risk factors. retrospective cohort used data from Korean National Health Insurance Service database included 59,340 patients without history who underwent surgery between January 1, 2010, December 31, 2016. They were individually matched 1:2 by age with general population (n = 99,834). The mean follow-up period was 6.4 ± 2.6 years. Sub-distribution hazard ratios (sHRs) 95% confidence intervals (CIs) calculated considering death as competing adjusting for sociodemographic factors comorbidities. Breast (standard deviation) 51.5 (9.2) years had 39% increased compared to non-cancer controls (sHR 1.39, CI 1.36–1.42). During first year post-diagnosis, across all ages exhibited significantly elevated depression, sHR 3.23 (95% 3.08–3.37). Notably, younger 4.51 4.19–4.85), older 2.56 2.42–2.71). One post-surgery, (age ≤ 50 years) showed 1.16-fold increase in 1.16, 1.11–1.20), while > no change risk, which decreased over time. Use anthracycline, taxane, or endocrine therapy an 1.17, 1.13–1.22; 1.12, 1.07–1.16; 1.27, 1.14–1.41, respectively), showing 41% 1.41, 1.23–1.61). demonstrates association particularly heightened within post-diagnosis. Special attention needed meticulously screen depressive symptoms during early are premenopausal have undergone chemotherapy therapy.

Language: Английский

Citations

2
Association of Vascular Risk Factors with the Risk of Parkinson's Disease among Stroke Survivors—Population-Based Study DOI Creative Commons
Seo Yeon Yoon, Hyun Im Moon, Jin‐Hyung Jung

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Background Stroke survivors usually have many vascular risk factors (VRFs), and recent studies reported the association of VRFs with cognitive decline among stroke survivors, which are also associated PD risk. Therefore, we aimed to investigate how influenced occurrence in individuals stroke. Methods The Korean National Health Insurance Service database was used. We selected who experienced new-onset (ICD-10: I60-I64) between 2008 2016 followed up until 2019. diagnosed according ICD-10 code G20 rare intractable disease registration V124. Lifestyle were collected using self-reported questionnaires, comorbidities defined based on codes, medication, laboratory anthropometric findings. Cox proportional hazard analyses conducted evaluate incidence survivors. Results Among 284,799 3,274 cases over a median follow-up period 5.04 years. In history stroke, smoking (former smoking, ratio (HR) = 0.80, 95% confidence interval (CI), 0.72–0.88; current HR 0.66, CI, 0.58–0.76) alcohol consumption (moderate drinking, 0.83, 0.75–0.91; heavy 0.74, 0.59–0.94) decreased PD. Physically active had showed reduced trend for ( P 0.0508). As risk, increased diabetes mellitus (P <.001), particularly those duration ≥5 years (HR 1.38, 1.25–1.52). Conclusions Our results suggest that Understanding managing relation is needed management after

Language: Английский

Citations

0