Decreased Structural Connectivity Between Thalamic Nuclei and Hippocampus in Temporal Lobe Epilepsy—A Diffusion Tensor Imaging‐Based Study

European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 1, 2025

ABSTRACT Background Temporal lobe epilepsy (TLE) can lead to structural brain abnormalities, with thalamus atrophy being the most common extratemporal alteration. This study used probabilistic tractography investigate connectivity between individual thalamic nuclei and hippocampus in TLE. Methods Thirty‐six TLE patients who underwent pre‐surgical 3 Tesla magnetic resonance imaging (MRI) 18 healthy controls were enrolled this study. Patients subdivided into HS (TLE‐HS) MRI‐negative (TLE‐MRneg). Tractography whole segmentation, including parcellation, performed determine number of streamlines per mm hippocampus. Connectivity strength volume regions correlated clinical data. Results The entire ipsilateral seizure onset was significantly decreased TLE‐HS compared (Mann–Whitney‐ U test: p FDR < 0.01) anterior (ANT) as important contributor. Furthermore, ANT detected ( TLE‐MRneg which negatively duration ρ = −0.512, 0.025) positively frequency 0.603, 0.006). Moreover, −0.471, 0.042). Conclusions showed TLE‐HS, frequency. Understanding dynamics epileptogenic networks has potential shed light on surgery‐resistant refine selection process for ideal neurosurgical candidates, consequently enhancing post‐surgical outcomes.

Language: Английский

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Stimulation of the anterior thalamus can modulate behavior in multiple cognitive domains.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121101 - 121101

Published: Feb. 1, 2025

Language: Английский

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Advances in the Treatment of Epilepsy by Electrostimulation of the Pulvinar

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 20, 2025

Neuroregulatory therapy, encompassing deep brain stimulation and responsive neurostimulation, is increasingly gaining attention for the treatment of drug-resistant temporal occipital lobe epilepsy. Beyond approved anterior nucleus thalamus, pulvinar thalamus a potential target. Through confluence animal studies, electrophysiological research, imaging has been identified as having extensive connections with visual cortex, prefrontal limbic regions, multimodal sensory associative areas, playing pivotal role in multisensory integration serving propagation node both generalized focal This review synthesizes recent research on relation to cortical epileptic networks, well efficacy neuroregulatory therapy targeting Further warranted elucidate differential therapeutic effects stimulating various subregions specific mechanisms underlying epilepsy through stimulation.

Language: Английский

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Sawtooth delta of the thalamus: A physiological variant and the intracranial generator of rapid-eye movement sleep sawtooth waves

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: 249, P. 102770 - 102770

Published: April 19, 2025

Language: Английский

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