Transcranial electrical stimulation during functional magnetic resonance imaging in patients with genetic generalized epilepsy: a pilot and feasibility study DOI Creative Commons
Zachary D. Cohen, Mirja Steinbrenner, Rory J. Piper

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 19, 2024

Objective A third of patients with epilepsy continue to have seizures despite receiving adequate antiseizure medication. Transcranial direct current stimulation (tDCS) might be a viable adjunct treatment option, having been shown reduce epileptic in focal epilepsy. Evidence for the use tDCS genetic generalized (GGE) is scarce. We aimed establish feasibility applying during fMRI GGE study acute neuromodulatory effects tDCS, particularly on sensorimotor network activity. Methods Seven healthy controls and three received simultaneous acquisition while watching movie. Three conditions were applied: anodal, cathodal sham. Periods 60 s without applied between each condition. Changes cortex connectivity evaluated by calculating mean degree centrality across eight nodes defined Automated Anatomical Labeling atlas (primary motor (precentral left right), supplementary area (left mid-cingulum postcentral gyrus right)), conditions, participant. Results Simultaneous tDCS-fMRI was well tolerated both adverse effects. Anodal reduced (Friedman’s ANOVA Dunn’s multiple comparisons test; adjusted p = 0.02 0.03 respectively). Mean sham condition not different rest (adjusted 0.94). Conclusion Applying feasible safe small group GGE. caused significant reduction participants. This initial research supports using guide understand modulation that facilitate its clinical application future.

Language: Английский

Adult epilepsy DOI
Ali A. Asadi‐Pooya, Francesco Brigo, Simona Lattanzi

et al.

The Lancet, Journal Year: 2023, Volume and Issue: 402(10399), P. 412 - 424

Published: July 1, 2023

Language: Английский

Citations

107
Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation DOI Creative Commons
Flavia Venetucci Gouveia, Nebras M. Warsi, Hrishikesh Suresh

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00308 - e00308

Published: Jan. 4, 2024

Epilepsy is a common and debilitating neurological disorder, approximately one-third of affected individuals have ongoing seizures despite appropriate trials two anti-seizure medications. This population with drug-resistant epilepsy (DRE) may benefit from neurostimulation approaches, such as vagus nerve stimulation (VNS), deep brain (DBS) responsive (RNS). In some patient populations, these techniques are FDA-approved for treating DRE. VNS used adjuvant therapy children adults. Acting via the afferent network, modulates thalamocortical circuits, reducing in 50 ​% patients. RNS uses an adaptive (closed-loop) system that records intracranial EEG patterns to activate at time, being particularly well-suited treat arising within eloquent cortex. For DBS, most promising therapeutic targets anterior centromedian nuclei thalamus, nucleus DBS focal secondarily generalized forms DRE applied epilepsies Lennox-Gastaut syndrome. Here, we discuss indications, advantages limitations VNS, summarize spatial distribution neuroimaging observations related using NeuroQuery NeuroSynth.

Language: Английский

Citations

21
Neuro-stimulation in focal epilepsy: A systematic review and meta-analysis DOI
Henry C. Skrehot, Dario J. Englot, Zulfi Haneef

et al.

Epilepsy & Behavior, Journal Year: 2023, Volume and Issue: 142, P. 109182 - 109182

Published: March 25, 2023

Language: Английский

Citations

24
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices DOI
John P. Andrews, Jinghui Geng, Kateryna Voitiuk

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Language: Английский

Citations

8
Use of Recommended Neurodiagnostic Evaluation Among Patients With Drug-Resistant Epilepsy DOI
Henry M. Spotnitz, Cameron D. Ekanayake, Anna Ostropolets

et al.

JAMA Neurology, Journal Year: 2024, Volume and Issue: 81(5), P. 499 - 499

Published: April 1, 2024

Interdisciplinary practice parameters recommend that patients with drug-resistant epilepsy (DRE) undergo comprehensive neurodiagnostic evaluation, including presurgical assessment. Reporting from specialized centers suggests long delays to referral and underuse of surgery; however, longitudinal data are limited characterize evaluation among DRE in more diverse US settings populations.

Language: Английский

Citations

7
An approach to detect and predict epileptic seizures with high accuracy using convolutional neural networks and single-lead-ECG signal DOI
Mostafa Ghaempour, Kourosh Hassanli, Ebrahim Abiri

et al.

Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(2), P. 025041 - 025041

Published: Feb. 15, 2024

One of the epileptic patients' challenges is to detect time seizures and possibility predicting. This research aims provide an algorithm based on deep learning predict seizure from one two minutes before its occurrence. The proposed Convolutional Neural Network (CNN) can occurrence focal epilepsy through single-lead-ECG signal processing instead using EEG signals. structure CNN for detection prediction same. Considering requirements a wearable system, after few light pre-processing steps, ECG be used as input neural network without any manual feature extraction step. desired learns purposeful features according labelled signals then performs classification these Training 39-layer has been done separately. method with accuracy 98.84% them 94.29%. With this approach, promising indicator construction portable systems monitoring status patients.

Language: Английский

Citations

5
Intraparenchymal delivery of adeno-associated virus vectors for the gene therapy of neurological diseases DOI

Shinichi Kumagai,

Takeshi Nakajima,

Shin‐ichi Muramatsu

et al.

Expert Opinion on Biological Therapy, Journal Year: 2024, Volume and Issue: 24(8), P. 773 - 785

Published: July 27, 2024

In gene therapy with adeno-associated virus (AAV) vectors for diseases of the central nervous system, can be administered into blood vessels, cerebrospinal fluid space, or brain parenchyma. When transfer to a large area is required, first two methods are used, but in which local expected effective, directly

Language: Английский

Citations

5
Low‐Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad‐Spectrum Efficacy Across Models of Epilepsy DOI Creative Commons

Shuang Zou,

Yiwei Gong,

Mengqi Yan

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

The limited efficacy and very restricted antiseizure range of current deep brain stimulation (DBS) targets highlight the need to find an optimal target for managing various seizure types. Here, we aimed investigate DBS on ventromedial hypothalamus (VMH) in different types experimental epileptic seizures. was examined models, potential mechanisms were investigated by using vivo calcium signal recording optogenetics. c-fos expression significantly increased glutamatergic neurons VMH (VMHglu) following Then, 1-Hz low-frequency (LFS) at successfully attenuated severities across models epilepsy, including maximal electroshock, pentylenetetrazol, absence seizure, cortical or hippocampal kainic acid-induced acute hippocampal-kindling models. imaging recordings revealed that LFS could inhibit activities VMHglu. Optogenetic inhibition VMHglu mirrored LFS's impact. Further anterograde viral tracing confirmed extensive distributed projections VMHglu, which may compose circuitry basis broad-spectral LFS. These findings demonstrate VMH-LFS is a broad-spectrum treatment approach decreasing activity.

Language: Английский

Citations

0
Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy DOI Creative Commons

Linda Iris Joseph Tomy,

Elif Köksal Ersöz, Anca Nica

et al.

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(4), P. e1012943 - e1012943

Published: April 28, 2025

The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism action. In this study, we used stereoelectro-encephalography (SEEG) signals recorded from a patient with refractory epilepsy, caused focal cortical dysplasia, which is malformation development. SEEG recordings revealed that neocortical interictal discharges could be suppressed CMS. These effects were found to frequency-dependent: while 50 Hz CMS induced no change in epileptiform activity, at 70 Hz, 100 and 150 led periods suppression activity. shown have different durations depending on the protocol. We developed neurophysiologically-plausible thalamocortical model explain these observations. This included glutamatergic subpopulations GABAergic thalamic compartments. Synaptic inhibition short-term plasticity mechanisms integrated into latter compartment. hypothesized enhanced activation inhibitory during high frequency (>70Hz) would result GABA spillover activated synaptic receptors relay cells. decreased driving-input neocortex, hence suppressing dysplastic tissue. While cells was maximal for not case CMS, suggesting presynaptic rate reuptake increased. Thus, our suggests transient epileptic activity may primarily due extra-synaptic tonic findings contribute deeper understanding high-frequency epilepsy pave way further research optimization approach.

Language: Английский

Citations

0
Comparison of Deep Brain Stimulation of the Hippocampus to Thalamic Targets and Responsive Neurostimulation for Adult Intractable Epilepsy: A Systematic Review and Meta-Analysis DOI Creative Commons
Norris C Talbot, James P. Bridges,

Patrick M. Luther

et al.

World Neurosurgery, Journal Year: 2025, Volume and Issue: 194, P. 123621 - 123621

Published: Jan. 23, 2025

Stereotactic neuromodulation, such as deep brain stimulation (DBS) and responsive neurostimulation (RNS), have emerged some of the more promising means for managing drug-resistant epilepsy. This study serves a comprehensive analysis DBS anterior nucleus thalamus (ANT), centromedian thalamic (CMT), hippocampus RNS seizure reduction in adult intractable Following PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines, systematic review was conducted PubMed, Cochrane Library, Embase databases from January 2000 to 2024 objectively assess effectiveness various neuromodulation modalities on reduction. Different software EndNote Rayyan utilized organize 1996 total reviewed studies run blinded multi-phase process. A 25 were included with 21 166 patients suitable meta-analysis. ANT, hippocampus, all found significant individual reductions 54.0%, 70.0%, 63.5%. CMT excluded since only 1 met inclusion criteria was, therefore, not Furthermore, 3 analyzed procedures be when compared one another. Focal versus general epilepsy ANT also had no difference. significantly higher rate mesial temporal sclerosis normal imaging findings. These results provide vast amount supporting data these while indicating difference between operations. Therefore, this target population, operative decisions can made based surgeon preference patient circumstance without affecting outcomes.

Language: Английский

Citations

0