Focal Infrared Neural Stimulation Propagates Dynamical Transformations in Auditory Cortex

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Significance Infrared neural stimulation (INS) has emerged as a potent neuromodulation technology, offering safe and focal with superior spatial recruitment profiles compared to conventional electrical methods. However, the dynamics induced by INS remain poorly understood. Elucidating these will help develop new paradigms advance its clinical application. Aim In this study, we assessed local network of entrainment in auditory thalamocortical circuit using chronically implanted rat model; our approach focused on measuring energy-based field potential (LFP) stimulation. We further characterized linear nonlinear oscillatory LFP activity response single-pulse periodic performed spectral decomposition uncover specific band INS. Finally, examined spike-field transformations across synapse spike-LFP coherence coupling. Results found that significantly increases amplitude log-linear function energy per pulse, primarily entraining β γ bands synchrony extending 200 Hz some cases. A subset neurons demonstrated nonlinear, chaotic oscillations linked information transfer cortical circuits. utilized coherences correlate spike coupling frequency suggest an energy-dependent model activation resulting from Conclusions show reliably drives robust can potently modulate potentials wide range frequencies stimulus parameter-dependent manner. Based results, propose design principles for developing full coverage, all-optical neuroprostheses.

Language: Английский

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A generalized epilepsy network derived from brain abnormalities and deep brain stimulation

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 24, 2025

Abstract Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this and its relevance for treatment remain unclear. We combine locations abnormalities in IGE (131 coordinates from 21 studies) with human connectome to identify an network. validate by showing alignment structural previously identified areas activated epileptiform discharges simultaneous electroencephalogram-functional magnetic resonance imaging. The topography aligns networks involved motor control loss consciousness consistent seizure semiology. To investigate therapeutic relevance, we analyze data patients treated deep stimulation (DBS) seizures. Seizure frequency reduced median 90% after DBS sites intersect peak centromedian nucleus thalamus. Together, study helps unify prior findings target that can be tested clinical trials

Language: Английский

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Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(4), P. e1012943 - e1012943

Published: April 28, 2025

The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism action. In this study, we used stereoelectro-encephalography (SEEG) signals recorded from a patient with refractory epilepsy, caused focal cortical dysplasia, which is malformation development. SEEG recordings revealed that neocortical interictal discharges could be suppressed CMS. These effects were found to frequency-dependent: while 50 Hz CMS induced no change in epileptiform activity, at 70 Hz, 100 and 150 led periods suppression activity. shown have different durations depending on the protocol. We developed neurophysiologically-plausible thalamocortical model explain these observations. This included glutamatergic subpopulations GABAergic thalamic compartments. Synaptic inhibition short-term plasticity mechanisms integrated into latter compartment. hypothesized enhanced activation inhibitory during high frequency (>70Hz) would result GABA spillover activated synaptic receptors relay cells. decreased driving-input neocortex, hence suppressing dysplastic tissue. While cells was maximal for not case CMS, suggesting presynaptic rate reuptake increased. Thus, our suggests transient epileptic activity may primarily due extra-synaptic tonic findings contribute deeper understanding high-frequency epilepsy pave way further research optimization approach.

Language: Английский

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The thalamus: Structure, function, and neurotherapeutics

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00550 - e00550

Published: Feb. 1, 2025

Language: Английский

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Neuromodulation: comparison of vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 337 - 353

Published: Nov. 15, 2024

Language: Английский

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