Microbioma humano y epigenética: nuevas fronteras en la salud personalizada

South Florida Journal of Development, Journal Year: 2025, Volume and Issue: 6(2), P. e5007 - e5007

Published: Feb. 24, 2025

En esta investigación se presenta la relación entre el microbioma humano y epigenética, enfocándose en su importancia salud personalizada presencia varias patologías como las crónicas, metabólicas, autoinmunes neurodegenerativas. A partir de revisión estudios recientes, analizan interacciones los microbiomas, tales intestinales piel, alteraciones epigenéticas que afectan procesos fundamentales, regulación del sistema inmunológico, metabólico progreso cognitivo. El objetivo es investigar cómo alteración microbiomas mediante alimentación, probióticos, ejercicio físico varios métodos terapéuticos sofisticados puede influir marcas epigenéticas, ofreciendo posibilidades para intervenciones particulares basándose características individuales. Se toman cuenta casos efecto microbiota primeros 1,000 días vida, conexión eje microbioma-cerebro durante envejecimiento resistencia a antimicrobianos metabólicas. Este método combina instrumentos análisis multiómico tecnologías actuales un entendimiento más detallado biológicas. Por último, artículo propone marco interdisciplinario reinterpreta medicina actual, indicando profundo vínculo con epigenética transformar prevención tratamiento enfermedades desde una perspectiva personalizada.

Epigenetic Diversity and the Evolutionary Potential of Wild Populations

Evolutionary Applications, Journal Year: 2024, Volume and Issue: 17(10)

Published: Oct. 1, 2024

ABSTRACT Fast‐paced selective pressures imposed by climate change and anthropogenic activities call for adaptive evolutionary responses to emerge at ecological timescales. However, the evolution heritability of genomic variation underlie mechanistic constraints, which dictate a slower pace adaptation exclusively relying on standing genetic novel mutations. Environmentally responsive epigenetic mechanisms can allow acclimatisation phenotypes arise faster than DNA sequence‐based alone. Nevertheless, knowledge gap between identifying marks effectively deeming them functional is still wide in natural context often outside scope model organisms. With this Special Issue, we aimed narrow presenting compilation original research articles, reviews opinions topic epigenetics wild populations. We contextualised collection within overarching conservation biology, as firmly propose that significantly enhance effectiveness measures. Contributions highlighted putative role potential species populations directly indirectly affected climatic shifts actions. They further exemplified how be used biomarkers monitoring variations physiology, phenology behaviour. Lastly, perspective articles illustrated past present while suggesting future avenues.

Language: Английский

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Global health and food supply are endangered by an increasing frequency of antifungal resistance in pathogenic fungi. Wild-type fission yeast, Schizosaccharomyces pombe , can gain to insults such as caffeine compounds through reversible epimutations. Resistant epimutants exhibit histone H3K9 methylation-dependent heterochromatin islands at various chromosomal locations, reducing expression underlying genes. Two genes whose island-induced repression causes encode mitochondrial proteins: the LYR domain protein Cup1 Cox1 translation regulator Ppr4. Genetic mutations, cup1-tt ppr4Δ that phenocopy their respective epimutants, cause dysfunction, including respiratory deficiency, poor growth on non-glucose carbon sources, elevated reactive oxygen species. RNA-Seq analyses indicate cells activate mitonuclear retrograde pathway Pap1 transcription factor-dependent oxidative stress response pathways. Both mutants show increased nuclear localisation its recruitment promoters encoding oxidoreductases membrane transporters, causing efflux activity. cup1 ppr4 also dysfunction phenotypes efflux, explaining how heterochromatin-island epimutations drug resistance. Thus, wild-type harness impose bypass external insults. As has been linked several fungi, similar likely contribute development fungal pathogens.

Language: Английский