Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 817 - 817

Published: June 16, 2024

Skin is the largest organ and a multifunctional interface between body its environment. It acts as barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, it also known mirror of soul. The skin involved in temperature regulation by storage fat water. an interesting tissue regard to local transdermal application active ingredients for prevention treatment pathological conditions. Topical delivery emerging route drug cosmetic administration. beneficial avoiding side effects rapid metabolism. Many pharmaceutical, technological innovations have been described patented recently field. In this review, main features morphology physiology are presented being followed description classical novel nanoparticulate dermal formulations. biophysical aspects penetration drugs cosmetics into across their investigation diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems with advanced analytical techniques shown. current knowledge about mathematical modeling future perspectives briefly discussed end, all involving nanoparticulated systems.

Language: Английский

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Potential Applications of Chitosan in Seborrheic Dermatitis and Other Skin Diseases: A Comprehensive Review

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 533 - 542

Published: March 1, 2025

This review article explores the potential applications of chitosan, a natural polysaccharide derived from crustacean shells, in treatment seborrheic dermatitis (SD) and other skin diseases. SD is common chronic inflammatory condition characterized by erythema, scaling, itching, an oily appearance, predominantly affecting areas rich sebaceous glands. Current treatments, including antifungal agents, corticosteroids, calcineurin inhibitors, offer symptomatic relief but have limitations long-term use due to side effects resistance issues. Chitosan exhibits excellent biocompatibility, biodegradability, broad-spectrum antibacterial properties, making it promising candidate for treatment. highlights chitosan's multifunctional properties such as antimicrobial, anti-inflammatory, sebum-regulating, barrier-enhancing effects, which are closely related pathogenesis SD. Additionally, summarizes chitosan conditions, wound healing, infectious diseases, atopic dermatitis, demonstrating its broad therapeutic potential. Through this comprehensive evaluation, aims provide theoretical foundation clinical research on support development new, safer, more effective options various conditions.

Language: Английский

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Seborrheic Dermatitis: Exploring the Complex Interplay with Malassezia

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2650 - 2650

Published: March 14, 2025

Seborrheic dermatitis (SD) is a chronic inflammatory skin condition often involving the sebaceous-rich areas, characterized by erythematous scaly lesions. It frequently observed in individuals with immune dysregulation, suggesting interplay between system and disease development. An altered environment leads to an exaggerated response activation of innate immunity, participation mast cells, γδ T NOD–LRR–pyrin-domain-containing protein 3 (NLRP3) inflammasome. This review aims assess complex relationship Malassezia pathogenesis SD. We will explore how impaired predisposes overgrowth infection. examine role adaptive particularly helper driving inflammation All actors involved, whether part or are responsible for release pro-inflammatory cytokines, which contribute progression disease. Therapeutic strategies aimed at modulation SD have been tested clinical trials evaluating efficacy immunomodulatory treatments management synthesizes insights from immunological studies present in-depth analysis mechanisms underpinning SD, thereby proposing targeted therapeutic its management.

Language: Английский

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Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial

Journal of Lipid Research, Journal Year: 2024, Volume and Issue: 65(8), P. 100591 - 100591

Published: July 9, 2024

Language: Английский

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Ocular Manifestations in Seborrheic Dermatitis Epidemiology, Clinical Features, and Management: A Comprehensive Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Seborrheic dermatitis (SD) often leads to ocular manifestations (OM) that are frequently overlooked. This study comprehensively explains the genesis of these issues, which involves a combination Malassezia overgrowth, changes in sebum production, and inflammatory responses body. The periocular region is rich sebaceous glands, allowing thrive, can lead an reaction spreads eye surface, causing disorders such as blepharitis, conjunctivitis, keratitis, surface diseases. Although epidemiological data limited, it well established involvement occurs approximately 10%-40% individuals with SD. Early detection treatment crucial prevent potential vision-threatening complications. A comprehensive diagnostic approach necessary, including clinical examination, slit-lamp biomicroscopy, tear film analysis, corneal imaging. Managing conditions requires multidisciplinary strategy involving collaboration between dermatologists ophthalmologists. should involve topical systemic medications address skin components. Patient education critical for improving adherence therapy, self-management, early identification problems. In future, will be essential investigate intricate interactions species host immunological processes. collective effort creating new biomarkers tools, investigating targeted immunomodulatory drugs novel lipid-based medicines treatments, conducting large-scale longitudinal studies understand patterns prognostic variables better. By raising awareness, encouraging across disciplines, advancing research, healthcare practitioners significantly improve patients' quality life SD OM.

Language: Английский

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Going Beyond Ceramides in Moisturizers: The Role of Natural Moisturizing Factors

Journal of Drugs in Dermatology, Journal Year: 2024, Volume and Issue: 23(6), P. 466 - 471

Published: May 1, 2024

Xerosis is experienced by almost everyone at some time in their lives and the foundation of management dry skin (both consumer- healthcare professional--directed) rests on use moisturizers. Given wide range available moisturizers, counseling patients about selecting optimum moisturizer for individual situation relies knowledge ingredients formulations. Traditionally, main focus many moisturizers centered core functional structural role ceramides within epidermal barrier. However, while a key aspect transepidermal water loss other barrier functions, components than are equally essential increasing moisturization. The skin's natural moisturizing factors (NMFs) complex mixture water-attracting compounds such as amino acids, urea, lactate, pyrrolidone carboxylic acid (PCA), electrolytes which play fundamental preserving physiologic function regulating content stratum corneum. By facilitating retention, NMFs contribute significantly to suppleness, elasticity, normal desquamation, overall integrity Incorporation into addresses critical deficiencies moisture balance that exist xerotic atopic skin, disorders, mitigating signs symptoms associated with xerosis promoting optimal health. biochemical composition intricate interplay homeostasis translate central used prophylactic therapeutic various conditions, beyond alone.

Language: Английский

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Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14315 - 14315

Published: Sept. 20, 2023

Facial seborrheic dermatitis (SD) is an inflammatory skin disease characterized by erythematous and scaly lesions on the with high sebaceous gland activity. The yeast Malassezia regarded as a key pathogenic driver in this disease, but increased Staphylococcus abundances barrier dysfunction are implicated well. Here, we evaluated antimicrobial peptide omiganan treatment for SD since it has shown both antifungal antibacterial A randomized, patient- evaluator-blinded trial was performed comparing four-week, twice daily topical administration of 1.75%, comparator ketoconazole 2.00%, placebo patients mild-to-moderate facial SD. Safety monitored, efficacy determined clinical scoring complemented imaging. Microbial profiling performed, integrity assessed trans-epidermal water loss ceramide lipidomics. Omiganan safe well tolerated did not result significant improvement SD, nor affect other biomarkers, compared to placebo. Ketoconazole significantly reduced severity placebo, abundances, microbial diversity, restored function, decreased short-chain Cer[NSc34]. No decreases were observed efficacious Previously established properties could be demonstrated. Our multimodal characterization response reaffirmed previous insights into its mechanism action.

Language: Английский

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Adult and infantile seborrheic dermatitis: update on current state of evidence and potential research frontiers

International Journal of Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Abstract Seborrheic dermatitis (SD) is a highly prevalent dermatological condition globally. The demonstrates bimodal presentation with what commonly thought to be two subtypes: adult/adolescent seborrheic (ASD) and infantile (ISD). Despite the common prevalence of ASD ISD, there remains uncertainty around underlying pathogenetic mechanisms, risk factors, appropriate classification disease(s). This narrative review summarizes current understanding epidemiology, presentation, factors like epidermal barrier dysfunction, lipid abnormalities, cutaneous microbiome for ISD. Elements such as immune responsiveness, neuroendocrine genetics in these disease states are also investigated. Throughout our review, we highlight shared features discrepancies between ISD that present literature discuss potential avenues future research explore states. We aim contribute medical discourse on increase awareness need additional conditions, ultimately informing better targeting therapeutics moving forward.

Language: Английский

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Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function

Experimental Dermatology, Journal Year: 2024, Volume and Issue: 33(10)

Published: Oct. 1, 2024

ABSTRACT Psoriasis is an inflammatory skin disease associated with impaired barrier. The barrier function dependent on the extracellular lipid matrix which surrounds corneocytes in stratum corneum. Ceramides comprise essential components of this matrix. Alterations corneum ceramide profile have been directly linked to dysfunction and might be underlying factor impairment psoriasis. In study, we investigated Lesional non‐lesional 26 patients 10 healthy controls were analysed using in‐depth lipidomics by liquid chromatography‐mass spectrometry. Barrier was assessed measuring transepidermal water loss. showed a significant decrease abundance total ceramides alterations subclass composition compared control skin. Additionally, percentage monounsaturated significantly increased, average chain length decreased lesional Altogether, resulted markedly different for skin, but not Importantly, reduced psoriasis correlated profile, highlighting their interdependence. By assessing parameters 2 weeks apart, are able highlight reproducibility these findings, further affirms connection. To conclude, show that changes observed in, limited to, psoriatic Their direct correlation provides mechanistic basis concomitantly dysfunction.

Language: Английский

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Seborrheic Dermatitis: From Microbiome and Skin Barrier Involvement to Emerging Approaches in Dermocosmetic Treatment

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 208 - 208

Published: Nov. 28, 2024

Seborrheic dermatitis (SD) is a chronic inflammatory skin disease that primarily affects sebaceous-rich areas such as the scalp, face, and upper trunk. While precise etiology remains multifactorial, role of microbiome, particularly proliferation Malassezia species, alterations in barrier function are critical its pathogenesis. Disruption barrier, characterized by increased transepidermal water loss (TEWL) reduced production epidermal lipids, creates favorable environment for microbial overgrowth inflammation. Recent insights highlight interplay between impaired function, immune responses, microbiome perpetuating disease. Additionally, novel dermocosmetic approaches emerging target these underlying mechanisms, offering promising therapeutic avenues. This review provides comprehensive overview involvement dysfunction seborrheic discusses potential advanced treatments aimed at restoring homeostasis preventing recurrence.

Language: Английский

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