Research Progress in Skin Aging and Immunity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4101 - 4101

Published: April 7, 2024

Skin aging is a complex process involving structural and functional changes characterized by decrease in collagen content, reduced skin thickness, dryness, the formation of wrinkles. This underpinned multiple mechanisms including free radical theory, inflammation photoaging metabolic theory. The immune system, an indispensable part body’s defense mechanism, comprises macrophages, lymphocytes, dendritic cells, mast cells. These cells play pivotal role maintaining homeostasis responding to injury or infection. As age advances, along with various internal external environmental stimuli, may undergo senescence accelerated aging, cell division capability, increased mortality, gene expression patterns signaling pathways, altered functions. collectively impact overall function system. review summarizes relationship between immunity explores characteristics composition effects these on aging. Immune dysfunction plays significant suggesting that immunoregulation become one important strategies for prevention treatment

Language: Английский

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Bioactive Substances and Skin Health: An Integrative Review from a Pharmacy and Nutrition Perspective

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 373 - 373

Published: March 6, 2025

The skin is one of the largest and most important organs our body. There are numerous factors that related to health, including lifestyle factors, nutrition, or care. Bioactive substances from plant marine extracts play a key role in health. aim this research was compile main evidence on bioactive substances. An integrative review performed, reporting findings according PRISMA (2020). Thirteen search equations were developed. After applications process screening selection articles, 95 references compiled. results compounds classified into food-derived components, nutraceuticals, symbiotics, active origin, extracts). several indicate use interesting for highlighting some dietary nutrients, obtained metabolites origin that, showing anti-inflammatory antimicrobial effects, improvement conditions principles cosmetics.

Language: Английский

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Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(3)

Published: March 1, 2025

Cutaneous tissue is one of the main targets outdoor stressors, and nowadays, effect pollution on skin conditions premature ageing has been well correlated, although exact that different pollutants have not defined, especially when compared to other stressors. Among air pollutants, UV radiation particulate matter (PM) found among most aggressive in terms damage, inducing oxinflammatory responses, promoting degradation extracellular matrix (ECM) components, compromising cutaneous defensive barrier. Topical application technologies able prevent oxidative damage still best approaches protect our skin, considering well-known antioxidant network, an mixture more recommended than a single compound. In present study, human explants were exposed every day for 4 days diesel particles (DEE) or after daily pre-treatment with topical commercially available (AOX Mix), containing 15% ascorbic acid, 0.5% ferulic acid 1% tocopherol. Oxidative stress markers such as 4-hydroxynonenal, barrier proteins involucrin, filaggrin, claudin-1 desmocollin-1, resilience elastin tropoelastin, levels Type I III collagens assessed. was induced by confirming protection needed ageing.

Language: Английский

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Therapeutic Effect of Liquiritin Carbomer Gel on Topical Glucocorticoid-Induced Skin Inflammation in Mice

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1001 - 1001

Published: July 28, 2024

Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is dangerous condition that develops after glucocorticoid use. The patients become dependent on medication and, even stopped, dermatitis symptoms recur, severely impairing their quality life. Thus, need to aggressively confront critical. Prior research has demonstrated administration licorice’s flavonoid component liquiritin stimulates epidermal proliferation, which turn enhances creation collagen healing wounds. Therefore, purpose this work was determine if use carbomer gel can treat changes mice mechanisms involved. findings that, model inflammation, aided restoration barrier function. These outcomes have been caused by enhanced expression proteins Aquaporin 3, Keratin 10, Claudin-1, as well hyaluronan content. In meantime, dramatically decreased TNF-α, IL-1β, IL-6, IFN-γ, IgE mice, according ELISA tests. Furthermore, treatment boosted superoxide dismutase, catalase, malondialdehyde expression, counteracting detrimental effects glucocorticoids epidermis. summary, these imply damage through various action.

Language: Английский

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Role of microbiota in the GUT-SKIN AXIS responses to outdoor stressors

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 894 - 909

Published: Nov. 1, 2024

Language: Английский

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