3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes DOI Creative Commons
Iwona Jarocka-Karpowicz, Izabela Dobrzyńska, Anna Stasiewicz

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1285 - 1285

Published: Oct. 24, 2024

Phospholipids and their metabolites play an important role in maintaining the membrane integrity metabolic functions of keratinocytes under physiological conditions regeneration process after exposure to high-energy UVB radiation. Therefore, search for compounds with a protective regenerative effect on keratinocyte phospholipids, effectiveness two antioxidant has been tested: stable derivative ascorbic acid, 3-O-ethyl acid (EAA) cannabigerol (CBG), both which are primarily located structures keratinocytes. In addition, this study demonstrated that EAA CBG, especially two-component combination, enhance properties reduce lipid peroxidation assessed at level MDA (malondialdehyde)/neuroprostanes. Moreover, by reducing activity enzymes metabolise free PUFAs (polyunsaturated fatty acids) endocannabinoids (PLA2; phospholipase A2, COX1/2; cyclooxygenases 1/2, LOX-5; lipoxygenase 5, FAAH; amide hydrolase, MAGL; monoacylglycerol lipase), antioxidants have found regulate levels (AEA; anandamide, 2-AG; 2-arachidonoylglycerol, PEA; palmitoylethanolamide) eicosanoids (PGD2; prostaglandin D2, PGE2; E2, 15-d-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2, 15-HETE; 15-hydroxyeicosatetraenoic acid), enhanced The groups PUFA is mainly related activation G protein-related receptors (CB1/2; cannabinoid receptor 1 2, PPARγ; peroxisome proliferator-activated gamma, TRPV1; transient potential cation channel subfamily V member 1), expression reduced influence EAA, combination. It promotes metabolism disrupted UVB, particularly relation redox balance inflammation.

Language: Английский

The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review DOI Creative Commons
Ai Kuzumi, Asako Yoshizaki‐Ogawa, Takemichi Fukasawa

et al.

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Language: Английский

Citations

5
Anti-Inflammatory Activity of Cannabis sativa L. Extract in 2,4-Dinitrochlorobenzene-Induced Dermatitis in Rats DOI Creative Commons
Renata Wolińska,

Maria Zalewska,

Piotr Poznański

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 370 - 370

Published: March 5, 2025

Background: Cannabis sativa L. and its products are becoming popular for the treatment of inflammatory diseases. One main phytocannabinoids contained in cannabis is cannabidiol (CBD), which a component numerous cosmetic preparations used to treat skin diseases such as atopic dermatitis (AD) psoriasis. However, current data regarding efficacy safety CBD dermatological indications limited. Therefore, aim present study was evaluate anti-inflammatory effect high-CBD extract (eCBD) model AD. Methods: Dermatitis induced by repeated application 2,4-dinitrochlorobenzene (DNCB) rats’ ears. The therapeutic eCBD evaluated behavioral, histopathological, hematological studies following topical an ointment containing 2% CBD. Results: Application resulted attenuation DNCB-induced inflammation. Interestingly, anti-edematous more pronounced rats treated with than 1% hydrocortisone ointment. did not reduce frequency scratching, while there visible antipruritic application. Histopathological analysis revealed that both ointments significantly decreased mast cell count compared Vaseline control group. Furthermore, decrease number leukocytes blood. Conclusions: Topically administered had stronger glucocorticosteroid differently affected parameters. It suggested has potential

Language: Английский

Citations

0
Targeting the Endocannabinoidome: A Novel Approach to Managing Extraintestinal Complications in Inflammatory Bowel Disease DOI Creative Commons
Dinesh Thapa,

Anshu Ghimire,

Leon N. Warne

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 478 - 478

Published: March 27, 2025

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder marked by persistent gastrointestinal inflammation and spectrum of systemic effects, including extraintestinal manifestations (EIMs) that impact the joints, skin, liver, eyes. Conventional therapies primarily target intestinal inflammation, yet they frequently fail to ameliorate these complications. Recent investigations have highlighted complex interplay among immune system, gut, nervous system in IBD pathogenesis, thereby underscoring need for innovative therapeutic approaches. Methods: We conducted comprehensive literature search using databases such as PubMed, Scopus, Web Science, Science Direct, Google Scholar. Keywords “cannabinoids”, “endocannabinoid system”, “endocannabinoidome”, “inflammatory disease”, “extraintestinal manifestations” were used identify peer-reviewed original research review articles explore role endocannabinoidome (eCBome) IBD. Results: Emerging evidence suggests eCBome—a network comprising lipid mediators, receptors (e.g., CB1, CB2, GPR55, GPR35, PPARα, TRPV1), metabolic enzymes—plays critical modulating responses, maintaining gut barrier integrity, regulating inflammation. Targeting eCBome not only improves but also appears mitigate metabolic, neurological, complications arthritis, liver dysfunction, dermatological disorders. Conclusions: Modulation represents promising strategy management addressing both local components. These findings advocate further mechanistic studies develop targeted interventions leverage novel avenue

Language: Английский

Citations

0
3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes DOI Creative Commons
Iwona Jarocka-Karpowicz, Izabela Dobrzyńska, Anna Stasiewicz

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1285 - 1285

Published: Oct. 24, 2024

Phospholipids and their metabolites play an important role in maintaining the membrane integrity metabolic functions of keratinocytes under physiological conditions regeneration process after exposure to high-energy UVB radiation. Therefore, search for compounds with a protective regenerative effect on keratinocyte phospholipids, effectiveness two antioxidant has been tested: stable derivative ascorbic acid, 3-O-ethyl acid (EAA) cannabigerol (CBG), both which are primarily located structures keratinocytes. In addition, this study demonstrated that EAA CBG, especially two-component combination, enhance properties reduce lipid peroxidation assessed at level MDA (malondialdehyde)/neuroprostanes. Moreover, by reducing activity enzymes metabolise free PUFAs (polyunsaturated fatty acids) endocannabinoids (PLA2; phospholipase A2, COX1/2; cyclooxygenases 1/2, LOX-5; lipoxygenase 5, FAAH; amide hydrolase, MAGL; monoacylglycerol lipase), antioxidants have found regulate levels (AEA; anandamide, 2-AG; 2-arachidonoylglycerol, PEA; palmitoylethanolamide) eicosanoids (PGD2; prostaglandin D2, PGE2; E2, 15-d-PGJ2; 15-deoxy-Δ12,14-prostaglandin J2, 15-HETE; 15-hydroxyeicosatetraenoic acid), enhanced The groups PUFA is mainly related activation G protein-related receptors (CB1/2; cannabinoid receptor 1 2, PPARγ; peroxisome proliferator-activated gamma, TRPV1; transient potential cation channel subfamily V member 1), expression reduced influence EAA, combination. It promotes metabolism disrupted UVB, particularly relation redox balance inflammation.

Language: Английский

Citations

1