Dual-drug codelivery nanosystems: An emerging approach for overcoming cancer multidrug resistance DOI Open Access
Jianing Gong,

Taoran Shi,

Jinfeng Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114505 - 114505

Published: March 13, 2023

Multidrug resistance (MDR) promotes tumor recurrence and metastasis heavily reduces anticancer efficiency, which has become a primary reason for the failure of clinical chemotherapy. The mechanisms MDR are so complex that conventional chemotherapy usually fails to achieve an ideal therapeutic effect even accelerates occurrence MDR. In contrast, combination with dual-drug significant advantages in therapy. A novel codelivery nanosystem, combines administration nanotechnology, can overcome application limitation free drugs. Both characteristics nanoparticles synergistic dual drugs contribute circumventing various drug-resistant cells. Therefore, developing nanosystems different multidrug-resistant important reference value reversing enhancing antitumor effect. this review, advantages, principles, common nanocarriers systems summarized. molecular designed based on mainly introduced. Meanwhile, development prospects challenges also discussed, provide guidelines exploit optimized combined strategies future.

Language: Английский

FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM DOI Creative Commons
Yaguang Bi, Haixia Xu, Xiang Wang

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(12)

Published: Dec. 5, 2022

Abstract Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its life-threatening cardiotoxicity severely limiting clinical application. Mitochondrial damage-induced cardiomyocyte death considered essential cue for DOX cardiotoxicity. FUN14 domain containing 1 (FUNDC1) a mitochondrial membrane protein participating in the regulation of integrity multiple diseases although role cardiomyopathy remains elusive. Here, we examined whether PANoptosis, novel type programmed cell closely associated damage, was involved DOX-induced heart injury, and FUNDC1-mediated if any. FUNDC1 downregulated tissues patients dilated (DCM) DOX-challenged mice. deficiency aggravated cardiac dysfunction, PANoptosis. Further examination revealed that countered cytoplasmic release DNA (mtDNA) activation PANoptosome through interaction Tu translation elongation factor (TUFM), key translational expression repair DNA, via 96–133 amino acid domain. TUFM intervention reversed FUNDC1-elicited protection against mtDNA cytosolic Our findings shed light toward beneficial thus offering therapeutic promises

Language: Английский

Citations

77
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging DOI Creative Commons
Annet N. Linders, Itamar Braga Dias, Teresa López‐Fernández

et al.

npj Aging, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 23, 2024

Abstract The population of cancer survivors is rapidly increasing due to improving healthcare. However, therapies often have long-term side effects. One example therapy-related cardiac dysfunction (CTRCD) caused by doxorubicin: up 9% the patients treated with this drug develop heart failure at a later stage. In recent years, doxorubicin-induced cardiotoxicity has been associated an accelerated aging phenotype and cellular senescence in heart. review we explain evidence doxorubicin-treated comparing it healthy aged hearts, shed light on treatment strategies that are proposed pre-clinical settings. We will discuss impact could clinic future research.

Language: Английский

Citations

57
DOXORUBICIN-RELATED CARDIOTOXICITY: REVIEW OF FUNDAMENTAL PATHWAYS OF CARDIOVASCULAR SYSTEM INJURY DOI
Ashot Avagimyan, Nana Pogosova, L. V. Kakturskiy

et al.

Cardiovascular Pathology, Journal Year: 2024, Volume and Issue: 73, P. 107683 - 107683

Published: Aug. 6, 2024

Language: Английский

Citations

19
Cyclodextrin-based nanocarriers as promising scaffolds for overcoming challenges of doxorubicin delivery in cancer chemotherapy DOI Creative Commons
Sara Payamifar, Amin Foroozandeh, Mehrab Pourmadadi

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100677 - 100677

Published: Jan. 1, 2025

Language: Английский

Citations

8
Marine algal polysaccharides for drug delivery applications: A review DOI

Nada E Ramadan,

Fatma Youssef,

Amira A K Alshishtawy

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139551 - 139551

Published: Jan. 7, 2025

Language: Английский

Citations

2
In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes DOI Creative Commons

Islam Alfreahat,

Hamdi Nsairat, Ibrahim Al‐Deeb

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing were prepared using thin film hydration method. The physicochemical properties liposomes, average particle size, polydispersity index (PDI), zeta potential, characterized. Encapsulation efficiencies assessed, stability was evaluated over 9 days at room temperature. Cell viability measured an IC50 assay, P-gp expression levels determined ELISA. CAM/DOX-PEGylated exhibited optimal size (238 ± 26.7 nm), PDI (0.29 0.107), potential (-20.9 2.17 mV). These maintained good regarding charge days. 81.05% 78.13% DOX. value 0.13 µM, representing significant reduction compared physical mixture (0.25 µM) free (0.21 cells. ELISA analysis showed approximately 5% with 1.61% results indicate that encapsulated enhances cells, likely inhibition p-glycoprotein. approach may offer promising strategy overcome improve chemotherapy outcomes.

Language: Английский

Citations

2
Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function DOI

Lingyue Gao,

Zhuo‐Xun Wu,

Yehuda G. Assaraf

et al.

Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 57, P. 100770 - 100770

Published: June 18, 2021

Language: Английский

Citations

98
Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies DOI Creative Commons
David Dahlgren, Markus Sjöblom, Per M. Hellström

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: May 4, 2021

The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota. As result, up 40–100% all cancer patients dosed chemotherapeutics experience toxicity, called chemotherapeutics-induced mucositis (CIM). condition associated histological changes inflammation in the mucosa arising from stem-cell apoptosis disturbed cellular renewal maturation processes. In turn, this results various pathologies, including ulceration, pain, nausea, diarrhea, bacterial translocation sepsis. addition reducing patient quality-of-life, CIM often leads dose-reduction subsequent decrease anticancer effect. Despite decades experimental clinical investigations remains an unsolved issue, there strong consensus that effective strategies are needed for preventing treating CIM. Recent progress understanding molecular functional pathology had provided many new potential targets opportunities treatment. This review presents overview functions physiology healthy barrier followed by summary pathophysiological mechanisms involved development Finally, we highlight some pharmacological microbial interventions shown potential. Conclusively, one must accept date no single treatment has substantially transformed management We therefore believe best chance success use combination treatments. An optimal will likely include prophylactics (e.g., antibiotics/probiotics) impact acute phase anti-oxidants, inhibitors, anti-inflammatory agents) as well recovery stimulation proliferation adaptation).

Language: Английский

Citations

96
Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD DOI Creative Commons
Lindsey R. Hayes, Petr Kaláb

Neurotherapeutics, Journal Year: 2022, Volume and Issue: 19(4), P. 1061 - 1084

Published: July 1, 2022

Language: Английский

Citations

43
Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade DOI Creative Commons
Aditi Gupta, Vineet Meshram, Mahiti Gupta

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1038 - 1038

Published: June 25, 2023

The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a milestone in recognizing the immense potential fungi as prolific producers bioactive secondary metabolites use medicine, agriculture, and food industries. Following paclitaxel, research community has intensified efforts to harness putative lead molecules with anticancer, anti-inflammatory, antimicrobial, antioxidant, cardio-protective, immunomodulatory properties. Endophytic have been valuable source compounds over last three decades. Compounds such taxol, podophyllotoxin, huperzine, camptothecin, resveratrol effectively isolated characterized after extraction fungi. These findings expanded applications medicine related fields. In present review, we systematically compile analyze several important derived fungi, encompassing period 2011 2022. Our systematic approach focuses on elucidating origins exploring structural diversity biological activities exhibited by these compounds, giving special emphasis pharmacological mechanism action certain compounds. We highlight tremendous alternate sources metabolites, implications for combating major global diseases. This underscores significant role that can play development novel therapeutic agents address challenges posed prevalent diseases worldwide.

Language: Английский

Citations

41