Integrative Analyses of Mitophagy-Related Genes and Mechanisms Associated with Type 2 Diabetes in Muscle Tissue DOI Creative Commons

Wangjia Mao,

Guannan Zong, Yuan Gao

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10411 - 10429

Published: Sept. 18, 2024

Type 2 diabetes (T2D) represents the most prevalent metabolic condition that is primarily distinguished by a range of imbalances, including hyperglycemia, hyperlipidemia, and insulin resistance (IR). Currently, mitophagy has become increasingly recognized as an important process involved in pathogenesis progression T2D. Therefore, it very to explore role mitochondrial damage autophagy-related genes This study investigated development T2D, 12 MRHGs associated with T2D were identified using bioinformatic analysis machine learning methods. Our findings provide first insight into mitophagy-related their mechanisms aimed investigate possible molecular targets for therapy underlying information might be useful further elucidate T2D-related diseases identify more optimal therapeutic approaches.

Language: Английский

Targeting organ-specific mitochondrial dysfunction to improve biological aging DOI Creative Commons
Corina T. Madreiter‐Sokolowski, Ursula Hiden, Jelena Krstić

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 262, P. 108710 - 108710

Published: Aug. 22, 2024

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related diseases is of utmost importance. Mitochondria are the primary ATP production sites key regulators programmed cell death. Consequently, these highly dynamic organelles play a central role in maintaining tissue function, mitochondrial dysfunction pivotal factor progressive age-related decline cellular homeostasis organ function. The current review examines recent advances understanding interplay between organ-specific aging. Thereby, we dissect molecular mechanisms underlying impairment associated with deterioration exploring DNA, reactive oxygen species homeostasis, metabolic activity, damage-associated patterns, biogenesis, turnover, dynamics. We also highlight emerging therapeutic preclinical clinical tests that supposed rejuvenate such as antioxidants, biogenesis stimulators, modulators turnover Furthermore, discuss potential benefits challenges use interventions, emphasizing need for approaches given unique characteristics different tissues. conclusion, this highlights addressing mitigate aging, focusing on skin, liver, lung, brain, skeletal muscle, well reproductive, immune, cardiovascular systems. Based comprehensive multifaceted roles mitochondria, innovative may be developed optimized biological promote healthy across diverse

Language: Английский

Citations

9
Isolation and Characterization of EVs Containing Mitochondria from OIS Cells DOI
Ines Martic, David Feldmann, Maria Cavinato

et al.

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 243 - 254

Published: Jan. 1, 2025

Language: Английский

Citations

0
Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness DOI Creative Commons
A. Morelli, Ann Saada, Felix Scholkmann

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

There are several physiological reasons why biological organisms sleep. One key one concerns brain metabolism. In our article we discuss the role of metabolism in myelin, based on recent discovery that myelin contains mitochondrial components enable production adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). These probably originate from vesiculation membranes form derived vesicles (MDVs). We hypothesize acts as a proton capacitor, accumulating energy protons during sleep and converting it to ATP OXPHOS wakefulness. Empirical evidence supporting hypothesis is discussed, including data metabolic activity, MDVs, allometric scaling between white matter volume duration mammals.

Language: Английский

Citations

0
Tracing the evolutionary pathway: on the origin of mitochondria and eukaryogenesis DOI Creative Commons

J. Ernesto Bravo‐Arévalo

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The mito‐early hypothesis posits that mitochondrial integration was a key driver in the evolution of defining eukaryotic characteristics (DECs). Building on previous work identified endosymbiotic selective pressures as central to cell evolution, this study examines how gene transfer (EGT) and resulting genomic bioenergetic constraints shaped protein import systems. These systems were crucial for maintaining cellular function early eukaryotes facilitated their subsequent diversification. A primary focus is co‐evolution mechanisms endomembrane complexity. Specifically, I investigate necessity nuclear‐encoded drove adaptation bacterial secretion components, alongside innovations, refine translocation pathways. Beyond enabling expansion, endosymbiosis played fundamental role emergence compartmentalisation complexity LECA, driving organellar networks. By integrating genomic, structural phylogenetic evidence, aimed contribute framework, clarifying linked acquisition origin cells.

Language: Английский

Citations

0
Mitostasis in age-associated neurodegeneration DOI
Mrutyunjaya Panda, Maria Markaki, Nektarios Tavernarakis

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 167547 - 167547

Published: Oct. 1, 2024

Language: Английский

Citations

1
The roles of secretory autophagy in mitochondria release via extracellular vesicles: waste disposal and food delivery? DOI Creative Commons
Yuhan Gong,

Yucheng Zhou,

Linhui Feng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: May 24, 2024

OPINION article Front. Cell Dev. Biol., 24 May 2024Sec. Membrane Traffic Volume 12 - 2024 | https://doi.org/10.3389/fcell.2024.1392810

Language: Английский

Citations

0
Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan DOI Creative Commons
José Viña, Consuelo Borrás

FEBS Letters, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

In an era of rising global life expectancies, research focuses on enhancing the quality extended years. This review examines link between mitochondrial function and aging, highlighting importance healthspan alongside lifespan. involves significant human economic challenges, with longer lifespans often accompanied by reduced well‐being. Addressing decline, exploring targeted interventions, understanding complexities models are vital for advancing our knowledge in this field. Additionally, promoting physical exercise adopting personalized supplementation strategies based individual needs can contribute to healthy aging. The insights from Perspective article offer a hopeful outlook future advances extending both lifespan healthspan, aiming improve overall aging populations.

Language: Английский

Citations

0
A critical review of multiscale modeling for predictive understanding of cancer cell metabolism DOI
Marco Vanoni, Pasquale Palumbo,

Stefano Busti

et al.

Current Opinion in Systems Biology, Journal Year: 2024, Volume and Issue: 39, P. 100531 - 100531

Published: July 20, 2024

Language: Английский

Citations

0
Extracellular Vesicles & Co.: scaring immune cells in the TME since ever DOI Creative Commons
Carlo Rodolfo, Silvia Campello

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

The health tissue surrounding a solid tumor, namely the tumor microenvironment (TME), is an extremely complex universe of cells, extracellular matrix, and signals various nature, that support protect growth cancer cells. interactions taking place between cells TME are crucial not only for growth, invasion, metastasis but they also play key role in modulating immune system responses to cancer, vice-versa. Indeed, tumor-infiltrating (e.g., T lymphocytes natural killers) activity greatly affected by (mostly ligands/receptors paracrine) receive TME, which frequently generate immunosuppressive milieu. In last years, it has become evident soluble receptor signaling way communication with vesicles, such as exosomes, playing central role. Among different new kind vesicles recently discovered, migrasomes look like be extreme interest from others, have been reported able deliver very heterogeneous messages, profoundly affect recipient cells’ behavior. played classes especially relies on their not-directional diffusion originating while released migrating do directional effect. Migrasomes biology involvement progression, dissemination, resistance therapy still largely obscure field, promising development foreseen next future.

Language: Английский

Citations

0
Integrative Analyses of Mitophagy-Related Genes and Mechanisms Associated with Type 2 Diabetes in Muscle Tissue DOI Creative Commons

Wangjia Mao,

Guannan Zong, Yuan Gao

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10411 - 10429

Published: Sept. 18, 2024

Type 2 diabetes (T2D) represents the most prevalent metabolic condition that is primarily distinguished by a range of imbalances, including hyperglycemia, hyperlipidemia, and insulin resistance (IR). Currently, mitophagy has become increasingly recognized as an important process involved in pathogenesis progression T2D. Therefore, it very to explore role mitochondrial damage autophagy-related genes This study investigated development T2D, 12 MRHGs associated with T2D were identified using bioinformatic analysis machine learning methods. Our findings provide first insight into mitophagy-related their mechanisms aimed investigate possible molecular targets for therapy underlying information might be useful further elucidate T2D-related diseases identify more optimal therapeutic approaches.

Language: Английский

Citations

0