Autophagy, ER-phagy and ER dynamics during cell differentiation DOI Creative Commons
Michele Cillo,

Viviana Buonomo,

Anna Vainshtein

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169151 - 169151

Published: April 1, 2025

The endoplasmic reticulum (ER) is a multifunctional organelle essential for protein and lipid synthesis, ion transport inter-organelle communication. It comprises highly dynamic network of membranes that continuously reshape to support wide range cellular processes. During differentiation, extensive remodelling both ER architecture its proteome required accommodate alterations in cell morphology function. Autophagy, ER-phagy particular, plays pivotal role reshaping the ER, enabling cells meet their evolving needs adapt developmental cues. Despite ER's critical mechanisms responsible regulating dynamics are not fully understood. Emerging evidence suggests transcriptional post-translational regulation play fine-tuning unfolded response (UPR). This review explores molecular basis autophagy ER-phagy, highlighting during differentiation. A deeper understanding these processes could open new avenues targeted therapeutic approaches conditions where impaired.

Language: Английский

Autophagy, ER-phagy and ER dynamics during cell differentiation DOI Creative Commons
Michele Cillo,

Viviana Buonomo,

Anna Vainshtein

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169151 - 169151

Published: April 1, 2025

The endoplasmic reticulum (ER) is a multifunctional organelle essential for protein and lipid synthesis, ion transport inter-organelle communication. It comprises highly dynamic network of membranes that continuously reshape to support wide range cellular processes. During differentiation, extensive remodelling both ER architecture its proteome required accommodate alterations in cell morphology function. Autophagy, ER-phagy particular, plays pivotal role reshaping the ER, enabling cells meet their evolving needs adapt developmental cues. Despite ER's critical mechanisms responsible regulating dynamics are not fully understood. Emerging evidence suggests transcriptional post-translational regulation play fine-tuning unfolded response (UPR). This review explores molecular basis autophagy ER-phagy, highlighting during differentiation. A deeper understanding these processes could open new avenues targeted therapeutic approaches conditions where impaired.

Language: Английский

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