Immunological response and implications of Ad26.COV2. S (Janssen COVID-19 vaccine) vaccine in diabetic patients: a prospective cohort study in Ethiopia DOI Creative Commons
Chala Kenenisa Edae,

Abdisa Tufa Bedada,

Maria Degef Teklemariam

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Patients with Diabetes are at increased risk of severe COVID-19 and death, thus, it is imperative to provide them vaccination. Ad26.COV2. S vaccine has proven its efficacy. However, the immunological response patients diabetes in Ethiopia not been well studied. This prospective cohort study assessed immune responses after vaccination a single dose Ad26.COV2.S. The subjects were enrolled diabetic who 18 years old above attended clinic Adama Hospital Medical College. A sufficient blood sample was collected from each participant, following established standard protocols. We evaluated correlations among selected parameters (IgG, IgM, CRP, IL6, IFN-Y) employed statistical techniques such as chi-square tests, independent t-tests, Generalized Estimating Equations (GEE) analyze differences between given vaccinated non-vaccinated cohorts. method for modeling longitudinal or clustered data, particularly useful when dealing non-normal data like binary count by estimating generalized linear model while accounting potential observations. It found that showed significant alterations IgM elevation temporary increase inflammatory biomarkers CRP IL-6. Younger age females associated lower markers, no effects lifestyle factors (alcohol, chat, smoking) on outcomes observed. elicited patients, characterized initial increases markers subsequent stabilization, implications healthcare policies design tailored approaches groups.

Language: Английский

Immunological response and implications of Ad26.COV2. S (Janssen COVID-19 vaccine) vaccine in diabetic patients: a prospective cohort study in Ethiopia DOI Creative Commons
Chala Kenenisa Edae,

Abdisa Tufa Bedada,

Maria Degef Teklemariam

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Patients with Diabetes are at increased risk of severe COVID-19 and death, thus, it is imperative to provide them vaccination. Ad26.COV2. S vaccine has proven its efficacy. However, the immunological response patients diabetes in Ethiopia not been well studied. This prospective cohort study assessed immune responses after vaccination a single dose Ad26.COV2.S. The subjects were enrolled diabetic who 18 years old above attended clinic Adama Hospital Medical College. A sufficient blood sample was collected from each participant, following established standard protocols. We evaluated correlations among selected parameters (IgG, IgM, CRP, IL6, IFN-Y) employed statistical techniques such as chi-square tests, independent t-tests, Generalized Estimating Equations (GEE) analyze differences between given vaccinated non-vaccinated cohorts. method for modeling longitudinal or clustered data, particularly useful when dealing non-normal data like binary count by estimating generalized linear model while accounting potential observations. It found that showed significant alterations IgM elevation temporary increase inflammatory biomarkers CRP IL-6. Younger age females associated lower markers, no effects lifestyle factors (alcohol, chat, smoking) on outcomes observed. elicited patients, characterized initial increases markers subsequent stabilization, implications healthcare policies design tailored approaches groups.

Language: Английский

Citations

0