Abstract
This
issue
contains
a
series
of
articles
describing
the
various
resources,
studies,
results,
and
future
directions
for
collaborative
study
on
genetics
alcoholism
(COGA).
The
integrative
approach
initiated
by
this
group
~30
years
ago
serves
as
an
excellent
example
strength
team
science.
Individually,
aspects
COGA
would
be
limited
in
their
impact
toward
improved
understanding
alcohol
use
disorder.
Collectively,
wholistic
which
spans
deep
longitudinal
phenotypic
assessments
families
to
include
application
large‐scale
omics
technologies
cell‐culture
based
molecular
studies
has
demonstrated
power
working
together.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 5, 2024
Abstract
Despite
neurobiological
overlap,
alcohol
use
disorder
(AUD)
and
body
mass
index
(BMI)
show
minimal
genetic
correlation
(r
g
),
possibly
due
to
mixed
directions
of
shared
variants.
We
applied
MiXeR
investigate
architecture
between
AUD
BMI,
conjunctional
false
discovery
rate
(conjFDR)
detect
loci
their
directional
effect,
Local
Analysis
(co)Variant
Association
(LAVA)
for
local
r
,
Functional
Mapping
Annotation
(FUMA)
identify
lead
single
nucleotide
polymorphisms
(SNPs),
Genotype-Tissue
Expression
(GTEx)
examine
tissue
enrichment,
BrainXcan
assess
associations
with
brain
phenotypes.
indicated
82.2%
polygenic
despite
a
−.03.
ConjFDR
identified
132
SNPs,
53
novel,
showing
both
concordant
discordant
effects.
GTEx
analyses
overexpression
in
multiple
regions.
Amygdala
caudate
nucleus
volumes
were
associated
BMI.
Opposing
variant
effects
explain
the
rg
implicated
regions
involved
executive
function
reward,
clarifying
overlap
mechanisms.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: April 29, 2023
Abstract
Research
has
identified
clinical,
genomic,
and
neurophysiological
markers
associated
with
suicide
attempts
(SA)
among
individuals
psychiatric
illness.
However,
there
is
limited
research
those
an
alcohol
use
disorder
(AUD),
despite
their
disproportionately
higher
rates
of
SA.
We
examined
lifetime
SA
in
4,068
DSM-IV
dependence
from
the
Collaborative
Study
on
Genetics
Alcoholism
(23%
attempt;
53%
female;
mean
age:
38).
Within
participants
AUD
diagnosis,
we
explored
risk
across
other
clinical
conditions,
polygenic
scores
(PGS)
for
comorbid
problems,
neurocognitive
functioning
attempt.
Participants
who
had
attempted
greater
trauma
exposure,
major
depressive
disorder,
post-traumatic
stress
substance
disorders
compared
to
not
suicide.
Polygenic
attempt,
depression,
PTSD
were
reporting
a
attempt
(ORs
=
1.22
–
1.44).
reported
also
decreased
right
hemispheric
frontal-parietal
theta
interhemispheric
temporal-parietal
alpha
electroencephalogram
resting-state
coherences
relative
did
not,
but
differences
small.
Overall,
report
appear
experience
levels
trauma,
have
more
severe
comorbidities,
carry
variety
problems.
Our
results
demonstrate
need
further
investigate
presence
disorders.
Abstract
This
issue
contains
a
series
of
articles
describing
the
various
resources,
studies,
results,
and
future
directions
for
collaborative
study
on
genetics
alcoholism
(COGA).
The
integrative
approach
initiated
by
this
group
~30
years
ago
serves
as
an
excellent
example
strength
team
science.
Individually,
aspects
COGA
would
be
limited
in
their
impact
toward
improved
understanding
alcohol
use
disorder.
Collectively,
wholistic
which
spans
deep
longitudinal
phenotypic
assessments
families
to
include
application
large‐scale
omics
technologies
cell‐culture
based
molecular
studies
has
demonstrated
power
working
together.
