Explicit Consideration of Temperature Improves Predictions of Toxicokinetic–Toxicodynamic Models for Flupyradifurone and Imidacloprid in Gammarus pulex

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(22), P. 15920 - 15929

Published: Oct. 25, 2022

In the face of global climate change, where temperature fluctuations and frequency extreme weather events are increasing, it is needed to evaluate impact on ecological risk assessment chemicals. Current state-of-the-art mechanistic effect models, such as toxicokinetic–toxicodynamic (TK–TD) often do not explicitly consider a modulating factor. This study implemented in widely used modeling framework, General Unified Threshold model for Survival (GUTS). We tested using data from toxicokinetic toxicity experiments with Gammarus pulex exposed insecticides imidacloprid flupyradifurone. The revealed increased TK rates increasing under chronic exposures. Using Arrhenius equation, we could include influence into modeling. By further testing different approaches, differences scaling TD parameters be identified, urging investigations underlying mechanisms. Finally, our results show that predictions TK–TD models improve if explicitly.

Language: Английский

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Glyphosate- and aminomethylphosphonic acid (AMPA)-induced mortality and residues in juvenile brown trout (Salmo trutta f. fario) exposed at different temperatures

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 16, 2024

Abstract Background Glyphosate is a broad-spectrum, non-selective systemic herbicide with commonly assumed low potential for accumulation in biota. Nevertheless, glyphosate has been shown to bioaccumulate the tissues of several organisms. To understand bioconcentration dynamics fish, brown trout ( Salmo trutta forma fario ) different age were exposed concentrations glyphosate, formulation Roundup® LB Plus, and major transformation product aminomethylphosphonic acid (AMPA) two, three, or four weeks at temperatures laboratory. Mortality rates determined, tissue samples collected end experiment ascertain AMPA residues by liquid chromatography coupled mass spectrometry (LC–MS/MS). Results Brown mortality during exposure was considerably higher 15 °C than 7 °C. Also, significant increase containing muscle, head, backbone, caudal fin increasing observed. Six-month-old fish contained more per kg wet weight after ten-month-old fish. The factors (BCFs) much °C, but both cases decreased concentrations. BCF formulated one parent compound. Approximately 30–42% organ-absorbed remained even when kept clean water lacking test substances three termination exposure. Conclusion Our study demonstrated that there an interaction between ambient temperature terms toxicity. Further it surrounding media lead significantly increased these tissues, although neither nor bioaccumulation animal expected due high solubility this chemical. As consequence, uptake humans through consumption contaminated edible very likely.

Language: Английский

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Speed it up: How temperature drives toxicokinetics of organic contaminants in freshwater amphipods

Global Change Biology, Journal Year: 2022, Volume and Issue: 29(5), P. 1390 - 1406

Published: Nov. 30, 2022

The acceleration of global climate change draws increasing attention towards interactive effects temperature and organic contaminants. Many studies reported a higher sensitivity aquatic invertebrates contaminant exposure with or fluctuating temperatures. hypothesis this study was that the is associated changes toxicokinetic processes determine internal concentrations contaminants consequently toxic effects. Therefore, influence on underlying mechanisms were studied in two key amphipod species (Gammarus pulex Hyalella azteca). Bioconcentration experiments carried out at four different temperatures mixture 12 relevant polar Tissue medium samples taken regular intervals analysed by online solid-phase extraction liquid chromatography high-resolution tandem mass spectrometry. Subsequently, rates modelled dependence using Arrhenius equation. An exponential relationship between versus observed could be well depicted applying Due to similar uptake elimination rates, bioconcentration factors generally constant across range. Furthermore, respiration mostly similar. However, some cases (citalopram, cyprodinil), factor appeared dependent, which potentially explained active biotransformation. toxicokinetics may particularly non-equilibrated systems, such as peaks summer exemplified modelling field measured pesticide peak where increased up fourfold along gradient. results provide novel insights into chemical uptake, biotransformation scenarios can improve environmental risk assessment.

Language: Английский

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Climate warming shifts riverine macroinvertebrate communities to be more sensitive to chemical pollutants

Global Change Biology, Journal Year: 2024, Volume and Issue: 30(4)

Published: March 31, 2024

Abstract Freshwaters are highly threatened ecosystems that vulnerable to chemical pollution and climate change. Freshwater taxa vary in their sensitivity chemicals changes species composition can potentially affect the of assemblages exposure. Here we explore potential consequences future change on freshwater macroinvertebrate stressors using UK as a case study. Macroinvertebrate under end century (2080–2100) baseline (1980–2000) conditions were predicted for 608 sites four scenarios corresponding mean temperature 1.28 3.78°C. toxicity data collated 19 hierarchical distribution model was used predict untested relatedness within Bayesian approach. All shifted assemblage compositions, increasing prevalence Mollusca, Crustacea Oligochaeta species, insect Odonata, Chironomidae, Baetidae species. Contrastingly, decreases projected Plecoptera, Ephemeroptera (except Baetidae) Coleoptera Shifts taxonomic associated with percentage at risk from For 3.78°C scenario, 76% all became more sensitive 18 chemicals, increased. Climate warming‐induced increases greatest exposed metals dependent composition, which varied spatially. warming is result use, environmental exposure chemicals. show that, even absence these climate‐chemical interactions, shifts due will increase impact biodiversity may double or quadruple by 21st century.

Language: Английский

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The reaction of the macroinvertebrate Gammarus pulex to lanthanum-modified bentonite (LMB)

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126172 - 126172

Published: March 1, 2025

Language: Английский

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Climate change drives persistent organic pollutant dynamics in marine environments

Communications Earth & Environment, Journal Year: 2025, Volume and Issue: 6(1)

Published: May 13, 2025

Language: Английский

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Chemical Ecological Risk Assessment for Aquatic Life Under Climate Change: A Review from Occurrence, Bioaccumulation, and Toxicity Perspective

Reviews of Environmental Contamination and Toxicology, Journal Year: 2025, Volume and Issue: 263(1)

Published: May 17, 2025

Language: Английский

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Elimination Resistance: Characterizing Multi-compartment Toxicokinetics of the Neonicotinoid Thiacloprid in the Amphipod Gammarus pulex Using Bioconcentration and Receptor-Binding Assays

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(24), P. 8890 - 8901

Published: June 7, 2023

Delayed toxicity is a phenomenon observed for aquatic invertebrates exposed to nicotinic acetylcholine receptor (nAChR) agonists, such as neonicotinoids. Furthermore, recent studies have described an incomplete elimination of neonicotinoids by amphipods. However, mechanistic link between binding and toxicokinetic modeling has not been demonstrated yet. The the neonicotinoid thiacloprid in freshwater amphipod Gammarus pulex was studied several exposure experiments, complemented with vitro vivo receptor-binding assays. Based on results, two-compartment model developed predict uptake kinetics G. pulex. An thiacloprid, independent phase duration, concentrations, pulses, observed. Additionally, assays indicated irreversible nAChRs. Accordingly, toxicokinetic-receptor consisting structural membrane protein (including nAChRs) compartment developed. successfully predicted internal concentrations across various experiments. Our results help understanding delayed toxic receptor-mediated effects toward arthropods caused suggest that more awareness long-term needed regulatory context. supports future assessment contaminants.

Language: Английский

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Elucidating the spatial distribution of organic contaminants and their biotransformation products in amphipod tissue by MALDI- and DESI-MS-imaging

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 264, P. 115468 - 115468

Published: Sept. 20, 2023

The application of mass spectrometry imaging (MSI) is a promising tool to analyze the spatial distribution organic contaminants in organisms and thereby improve understanding toxicokinetic toxicodynamic processes. MSI common method medical research but has been rarely applied environmental science. In present study, suitability assess their biotransformation products (BTPs) aquatic invertebrate key species Gammarus pulex was studied. Gammarids were exposed mixture (carbamazepine, citalopram, cyprodinil, efavirenz, fluopyram terbutryn). parent compounds BTPs analyzed by two methods (MALDI- DESI-HRMSI) after cryo-sectioning, LC-HRMS/MS dissection into different organ compartments. contaminats gammarid tissue could be successfully analytical methods. intestinal system identified as main site biotransformation, possibly due presence biotransforming enzymes. more sensitive provided higher confidence BTP identification chromatographic separation MS/MS. DESI found for contaminants, whereas additional biomarkers using MALDI. results demonstrate investigations on accumulated contaminants. However, both required high exposure concentrations. Further improvements ionization would needed address environmentally relevant

Language: Английский

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Importance of Dietary Uptake for in Situ Bioaccumulation of Systemic Fungicides Using Gammarus pulex as a Model Organism

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(9), P. 1993 - 2006

Published: March 22, 2023

Bioaccumulation of organic contaminants from contaminated food sources might pose an underestimated risk toward shredding invertebrates. This assumption is substantiated by monitoring studies observing discrepancies predicted tissue concentrations determined laboratory-based experiments compared with measured systemic pesticides in gammarids. To elucidate the role dietary uptake bioaccumulation, gammarids were exposed to leaf material trees treated a fungicide mixture (azoxystrobin, cyprodinil, fluopyram, and tebuconazole), simulating leaves entering surface waters autumn. Leaf concentrations, spatial distribution, leaching behavior fungicides characterized using liquid chromatography coupled high-resolution tandem mass spectrometry (LC-HRMS/MS) matrix-assisted laser desorption ionization-mass spectrometric imaging. The contribution leached taken up feeding was assessed assembling caged (no access) uncaged (access leaves) dynamics test system analyzed LC-HRMS/MS toxicokinetic modeling. In addition, summer scenario simulated where water initial source contamination sorption. uptake, translocation, biotransformation compound-dependent. Internal access much higher than autumn scenario, but difference minimal scenario. choice dissectioning did not avoid efficiently assimilated leaves, indicating relevance this exposure pathway field. present study demonstrates potential impact on situ bioaccumulation for shredders autumn, outside main application period. parameters obtained facilitate modeling environmental scenarios. uncovered significance detritivores warrants further consideration scientific as well regulatory perspectives. Environ Toxicol Chem 2023;42:1993-2006. © 2023 Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

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