Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases DOI Creative Commons
Michael T. Petassi, Yeonoh Shin,

Aidan M. Jessop

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Most eukaryotes possess two Rad51/RecA family DNA recombinases that are thought to have arisen from an ancient gene duplication event: Rad51, which is expressed in both mitosis and meiosis; Dmc1, only meiosis. To explore the evolutionary relationship between these recombinases, here, we present high-resolution CryoEM structures of

Language: Английский

Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases DOI Creative Commons
Michael T. Petassi, Yeonoh Shin,

Aidan M. Jessop

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Most eukaryotes possess two Rad51/RecA family DNA recombinases that are thought to have arisen from an ancient gene duplication event: Rad51, which is expressed in both mitosis and meiosis; Dmc1, only meiosis. To explore the evolutionary relationship between these recombinases, here, we present high-resolution CryoEM structures of

Language: Английский

Citations

1