Quantification of collagen fiber properties in alcoholic liver fibrosis using polarization-resolved second harmonic generation microscopy DOI Creative Commons
Saya Matsuzaki, Eiji Hase, Hiroki Takanari

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 13, 2023

Liver fibrosis is assessed mainly by conventional staining or second harmonic generation (SHG) microscopy, which can only provide collagen content in fibrotic area. We propose to use polarization-resolved SHG (PR-SHG) microscopy quantify liver terms of fiber orientation and crystallization. samples obtained from autopsy cases with stage F0-F4 were evaluated an microscope, 12 consecutive PR-SHG images acquired while changing the polarization azimuth angle irradiated laser 0° 165° 15° increments using polarizer. The (φ) degree (ρ) estimated images. SHG-positive area increased as progressed, was well consistent Sirius Red staining. value φ random regardless stage. mean ρ (ρ-mean), represents crystallinity, varied more progressed F3, converged a significantly higher F4 than other stages. Spatial dispersion (ρ-entropy) also showed variation F3 decreased F4. It shown that could new information on properties fibers human fibrosis.

Language: Английский

Magnetic resonance elastography-based prediction model for hepatic decompensation in NAFLD: A multicenter cohort study DOI
Beom Kyung Kim, Jaclyn Bergstrom,

Rohan Loomba

et al.

Hepatology, Journal Year: 2023, Volume and Issue: 78(6), P. 1858 - 1866

Published: May 19, 2023

Background and Aims: Magnetic resonance elastography (MRE) is an accurate, continuous biomarker of liver fibrosis; however, the optimal combination with clinical factors to predict risk incident hepatic decompensation unknown. Therefore, we aimed develop validate MRE-based prediction model for patients NAFLD. Approach Results: This international multicenter cohort study included participants NAFLD undergoing MRE from 6 hospitals. A total 1254 were randomly assigned as training (n = 627) validation cohorts. The primary end point was decompensation, defined first occurrence variceal hemorrhage, ascites, or HE. Covariates associated on Cox-regression combined construct a in then tested cohort. median (IQR) age values 61 (18) years 3.5 (2.5) kPa 60 (20) 3.4 cohort, respectively. multivariable that age, MRE, albumin, aspartate aminotransferase, platelets had excellent discrimination 3- 5-year (c-statistic 0.912 0.891, respectively) diagnostic accuracy remained consistent c-statistic 0.871 0.876 at 3 5 years, respectively, superior Fibrosis-4 both cohorts ( p < 0.05). Conclusions: An allows accurate assists stratification

Language: Английский

Citations

12
Interpretations of the Role of Plasma Albumin in Prognostic Indices: A Literature Review DOI Open Access
Kim Oren Gradel

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(19), P. 6132 - 6132

Published: Sept. 22, 2023

This review assesses how publications interpret factors that influence the serum or plasma albumin (PA) level in prognostic indices, focusing on inflammation and nutrition. On PubMed, a search for “albumin AND prognosis” yielded 23,919 results. From these records, indices were retrieved, their names used as strings PubMed. Indices found 10 more original research articles included. The same strings, restricted to “Review” “Systematic review”, retrieved indices. data comprised latest up of reviews. Thirty had 294 (6 covering two indices) 131 reviews, most which from recent years. A total 106 related PA inflammation, 136 For equivalent numbers 54 65. In conclusion, mention marker nutrition rather than inflammation. is contrast several general reviews nutritional guidelines, state but not Hypoalbuminemia should prompt clinicians focus inflammatory aspects patients.

Language: Английский

Citations

12
Role of noninvasive tests in the prognostication of metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Yue Wang,

Sherlot Juan Song,

Yichong Jiang

et al.

Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

In managing metabolic dysfunction-associated steatotic liver disease, which affects over 30% of the general population, effective noninvasive biomarkers for assessing disease severity, monitoring progression, predicting development liver-related complications, and treatment response are crucial.The advantage simple fibrosis scores lies in their widespread accessibility through routinely performed blood tests extensive validation different clinical settings.They have shown reasonable accuracy diagnosing advanced good performance excluding majority patients with a low risk complications.Among elevated serum scores, more specific imaging biomarker has proved useful to accurately identify at biomarkers, enhanced is most widely utilized been approved United States as prognostic biomarker.For availability vibration-controlled transient elastography largely improved past years, enabling use stiffness measurement (LSM) accurate assessment significant fibrosis, cirrhosis.Combining LSM other available enhances ability diagnose at-risk steatohepatitis; predict some reaching an comparable that biopsy.Magnetic resonance imaging-based modalities provide quantification though current utilization limited research settings.Expanding future practice depends on factors such cost facility availability.

Language: Английский

Citations

4
Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models DOI

Tannaz Jamialahmadi,

Mehdi Azizmohammad Looha, Sara Jangjoo

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Language: Английский

Citations

0
Deep Learning-Based Prediction Models for Liver-Related and Cardiovascular Events in Steatotic Liver Disease DOI

Shun‐ichi Wakabayashi,

Takefumi Kimura,

Nobuharu Tamaki

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease DOI Creative Commons
Shun Ishido,

Nobuharu Tamaki,

Yuka Takahashi

et al.

BMC Gastroenterology, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 17, 2023

Abstract Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular (CVD). However, the of developing CVD in patients lean NAFLD is not yet fully understood. Therefore, this study aimed to compare incidence Japanese and those non-lean NAFLD. Methods A total 581 (219 362 NAFLD) were recruited. All underwent annual health checkups least 3 years, was investigated during follow-up. The primary end-point years. Results 3-year new rates 2.3% 3.9%, respectively, there no significant difference between two groups ( p = 0.3). Multivariable analysis adjusted age, sex, hypertension, diabetes, NAFLD/non-lean revealed that age (every 10 years) as an independent factor associated odds ratio (OR) 2.0 (95% confidence interval [CI]: 1.3–3.4), whereas (OR: 0.6; 95% CI: 0.2–1.9). Conclusions comparable prevention needed even

Language: Английский

Citations

10
Role of Spleen Stiffness Measurement in the Evaluation of Metabolic Dysfunction-Associated Steatotic Liver Disease DOI

Elizabeth E. Williams,

Andrea Mladenovic,

Dheeksha Ranginani

et al.

Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: 69(4), P. 1444 - 1453

Published: Feb. 8, 2024

Language: Английский

Citations

3
Proposal for standardized ultrasound analysis of the salivary glands: Part 1 submandibular gland DOI Creative Commons
Henry T. Hoffman, Michael Koch, Robert L. Witt

et al.

Laryngoscope Investigative Otolaryngology, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 1, 2024

The Salivary Gland Committee of the American Academy Otolaryngology-Head and Neck Surgery seeks to standardize terminology technique for ultrasonograpy used in evaluation treatment salivary gland disorders.

Language: Английский

Citations

3
AI‐Based Platelet‐Independent Noninvasive Test for Liver Fibrosis in MASLD Patients DOI Creative Commons

Shun‐ichi Wakabayashi,

Takefumi Kimura,

Nobuharu Tamaki

et al.

JGH Open, Journal Year: 2025, Volume and Issue: 9(4)

Published: April 1, 2025

Noninvasive tests (NITs), such as platelet-based indices and ultrasound/MRI elastography, are widely used to assess liver fibrosis in metabolic dysfunction-associated steatotic disease (MASLD). However, platelet counts not routinely included Japanese health check-ups, limiting their utility large-scale screenings. Additionally, while effective, is costly less accessible routine practice. Most existing AI-based models incorporate these markers, restricting applicability. This study aimed develop a simple yet accurate AI model for staging using only demographic biochemical markers. retrospective analyzed biopsy-proven data from 463 MASLD patients. Patients were randomly assigned training (N = 370, 80%) test 93, 20%) cohorts. The incorporated age, sex, BMI, diabetes, hypertension, hyperlipidemia, blood markers (AST, ALT, γ-GTP, HbA1c, glucose, triglycerides, cholesterol). Support Vector Machine demonstrated high diagnostic performance, with an area under the curve (AUC) of 0.886 detecting significant (≥ F2). AUCs advanced F3) cirrhosis (F4) 0.882 0.916, respectively. Compared FIB-4, APRI, FAST score (0.80-0.96), SVM achieved comparable accuracy eliminating need count or elastography. accurately assesses patients without requiring Its simplicity, cost-effectiveness, strong performance make it well-suited screenings clinical use.

Language: Английский

Citations

0
Mechanobiology in the development and progression of non-alcoholic fatty liver disease: an updated review DOI Open Access

Emilie K. Mitten,

György Baffy

Metabolism and Target Organ Damage, Journal Year: 2023, Volume and Issue: 3(1), P. 2 - 2

Published: Jan. 1, 2023

Mechanobiology is a rapidly emerging field focused on the biological impact of physical forces at molecular, cellular, and tissue level. Living cells perceive mechanical cues transform them into biochemical signals through mechanotransduction. Mechanotransduction complex process that involves mechanosensors (which are located in plasma membrane or within cell) mechanotransmission to nucleus occurs either by connection between mechanosensor mechanosignaling pathways). Essential functions, including development, growth, motility, metabolism, depend mechanoresponses generated these events. Multiple lines evidence indicate disruption homeostasis may contribute pathogenesis non-alcoholic fatty liver disease (NAFLD), highly prevalent metabolic disorder characterized abnormal accumulation lipid droplets hepatocytes (steatosis) often associated with inflammation cell injury (steatohepatitis). While predicting individual predisposition adverse outcomes NAFLD remains challenge, there increasing steatosis steatohepatitis trigger early stages critically progression. Lipid lipotoxicity modify viscoelasticity, alter biomechanics sinusoids, initiate aberrant pathways mechanotransduction non-parenchymal cells, such as sinusoidal endothelial hepatic stellate cells. Interactions interfaces each other, extracellular matrix, blood flow profoundly altered steatohepatitis; changes promote pro-angiogenic pro-fibrotic milieu. A better understanding mechanobiology facilitate identification novel molecular cellular targets management NAFLD.

Language: Английский

Citations

9