Hepatology Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
We read with great interest the article in Hepatology Research titled "Hepatic Mac2-BP expression depends on liver fibrosis and inflammation due to fat accumulation patients metabolic dysfunction-associated steatotic disease (MASLD)" by Uojima et al.1 Their study adopted an immunohistochemical approach evaluate Mac-2 binding protein (M2BP) MASLD. There are few reports of M2BP tissue MASLD patients, this has potential lead understanding pathology The development refinement non-invasive tests present certain challenges clinical practice hepatology. In field, MASLD2 been proposed as a new concept for fatty disease, replacing conventional non-alcoholic disease. Although biopsy remains gold standard diagnosing including MASLD, limitations, such invasiveness, sampling errors, variability histopathological interpretation, economic costs, which hence prompted tests.3, 4 al. investigated hepatic MASLD.1 glycosylated isomer (M2BPGi) provides basis one most typical tests. Developed Japan, M2BPGi test covered health insurance since 2015, reported be useful degree progression various diseases, well predicting risk cancer.5 is characterized fact that cutoff value differs depending cause fibrosis, even at same stage there rapid reduction after sustained antiviral effect achieved against hepatitis C virus.6 Furthermore, recent years, developed quantitative measurement system, M2BPGi-Qt, more accurate than qualitative methods, now Japan.7 Thus, diagnostic tool proven efficacy being applied practical use. However, although based form M2BP, origin incompletely understood.8 cell-adhesive glycoprotein binds galectin 3 (also referred Mac-2), its M2BPGi. circulates patient's serum easily captured blood tests, but currently difficult measure. On staining, Kamada demonstrated strongly expressed hepatocytes livers patients,9 whereas Bekki showed stellate cells (HSCs) secrete vitro culture hepatocytes.10 Furthermore Gantumur prominent mRNA HSCs derived from fibrotic livers, also detected Kupffer cells. these findings, they predict might produce introduce serum,8 propose M2BP-producing exclusively livers.8 their study, liver, thereby established was localized sinusoidal cells, staining higher latter.7 Interestingly, appears associated hepatocytes, sinusoid. These findings would thus tend indicate involved different inflammatory processes. Moreover, grade found positively correlated levels, no significant correlation observed between levels. authors accordingly hypothesized differences production involvement Accordingly, it under conditions inflammation, levels M2BPGi, produced undergoes glycosylation spaces involving HSCs. More detailed studies will, nevertheless needed verify hypothesis. Notably, however, association indicates may identifying high severe inflammation. Similarly, strong could serve beneficial marker detecting versus markers stages. Despite important much not fully understood regarding process whereby glycosylated. interesting note stages, potentially improve our By investigating how related we hope research will only markers, elucidation Author declares conflict interests article. Approval protocol Institutional Review Board: N/A. Informed Consent: Registry Registration No. study/trial: Animal Studies: Data sharing applicable article, datasets were generated or analyzed during current study.
Language: Английский