Impact of multilamellar formulations on stratum corneum lipid organization and epidermal lipid barrier enhancement (Part II) DOI Creative Commons
Joachim W. Fluhr, Razvigor Darlenski,

S. Daehnhardt-Pfeiffer

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 578 - 589

Published: Aug. 1, 2024

Abstract Introduction The integrity of the stratum corneum (SC) is crucial for skin's barrier function, protecting against environmental stressors and minimizing transepidermal water loss. Advances in skincare formulations have introduced multilamellar systems designed to emulate SC's lipid composition organization. This study hypothesizes that application a cream will significantly impact content lamellar structure, thereby enhancing epidermal barrier. Methods A saturated phosphatidylcholine‐based was applied cohort adult subjects with very dry skin. Electron microscopy utilized analyse micro‐morphology its integration into lipid‐depleted SC. Lipid analysis conducted quantify changes intercellular matrix. Results Transmission‐electron (TEM) imaging demonstrated possesses structured arrangement comparable natural SC architecture. Short‐term revealed time‐dependent restoration bilayers, while 14‐day regimen showed marked increase lamellae density length within indicated significant total content, notable enhancements ceramide free fatty acid levels, without altering cholesterol levels. ratio further confirmed rebalancing composition. Discussion selectively increased specific lipids critical suggesting an action mechanism aligns regulatory processes. selective augmentation indicates potential formulation not only restore but also enhance barrier, maintenance physiological ratios compatibility intrinsic repair mechanisms. Conclusion confirms can improve structural integrity, indicating enhanced function. They are pivotal professionals, dermatologists, product developers, enriching understanding creams' benefits applications improving

Language: Английский

Impact of multilamellar formulations on stratum corneum lipid organization and epidermal lipid barrier enhancement (Part II) DOI Creative Commons
Joachim W. Fluhr, Razvigor Darlenski,

S. Daehnhardt-Pfeiffer

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 578 - 589

Published: Aug. 1, 2024

Abstract Introduction The integrity of the stratum corneum (SC) is crucial for skin's barrier function, protecting against environmental stressors and minimizing transepidermal water loss. Advances in skincare formulations have introduced multilamellar systems designed to emulate SC's lipid composition organization. This study hypothesizes that application a cream will significantly impact content lamellar structure, thereby enhancing epidermal barrier. Methods A saturated phosphatidylcholine‐based was applied cohort adult subjects with very dry skin. Electron microscopy utilized analyse micro‐morphology its integration into lipid‐depleted SC. Lipid analysis conducted quantify changes intercellular matrix. Results Transmission‐electron (TEM) imaging demonstrated possesses structured arrangement comparable natural SC architecture. Short‐term revealed time‐dependent restoration bilayers, while 14‐day regimen showed marked increase lamellae density length within indicated significant total content, notable enhancements ceramide free fatty acid levels, without altering cholesterol levels. ratio further confirmed rebalancing composition. Discussion selectively increased specific lipids critical suggesting an action mechanism aligns regulatory processes. selective augmentation indicates potential formulation not only restore but also enhance barrier, maintenance physiological ratios compatibility intrinsic repair mechanisms. Conclusion confirms can improve structural integrity, indicating enhanced function. They are pivotal professionals, dermatologists, product developers, enriching understanding creams' benefits applications improving

Language: Английский

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