C24 Ceramide Lipid Nanoparticles for Skin Wound Healing

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 242 - 242

Published: Feb. 12, 2025

Background/Objectives: C24 ceramide plays a crucial role in skin regeneration and wound healing; however, its hydrophobic nature limits application therapeutic formulations. This study aims to enhance the bioavailability efficacy of by developing ceramide-based lipid nanoparticles (C24-LNP) evaluate their impact on healing. Methods: C24-LNP was synthesized characterized for aqueous stability bioavailability. In vitro experiments were conducted assess effects keratinocyte proliferation migration. Molecular biological analysis examined key signaling pathways, including AKT ERK1/2 phosphorylation. Additionally, an vivo mouse model utilized healing efficacy, with histological performed epidermal dermal regeneration. Results: exhibited improved compared free ceramide. studies demonstrated that significantly promoted revealed activation which are critical cell growth showed accelerated closure control group. Histological confirmed enhanced regeneration, leading structural functional repair. Conclusion: The nanoparticle formulation effectively increases enhances presents scalable cost-effective alternative traditional factor-based therapies, offering significant potential clinical applications care dermatological treatments.

Language: Английский

Lipid Dysregulation in Sebaceous Gland Disorders and the Impact of Sphingolipid Metabolism on Acne Pathogenesis

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский