Open Life Sciences,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Jan. 1, 2024
Moroccan
Cannabis
sativa
L.
seeds
were
investigated
for
their
phenolic
profile
and
antidiabetic
potential.
Ultra-high-performance
liquid
chromatography
with
diode
array
detection
electrospray
ionization
mass
spectrometry
analysis
revealed
a
rich
composition,
including
benzoic
acid,
cannabisin
B,
genistein,
epicatechin.
In
vitro,
the
seed
extract
exhibited
potent
α-amylase
inhibitory
activity
(half-maximal
concentration
=
25.02
±
4.03
μg/mL).
vivo
studies
in
diabetic
rats
demonstrated
significant
hypoglycemic,
hypolipidemic,
hepatoprotective,
nephroprotective
effects.
Molecular
docking
further
supported
these
findings,
revealing
strong
interactions
between
identified
enzyme.
These
results
highlight
potential
of
C.
as
natural
source
bioactive
compounds
diabetes
management.
Notulae Scientia Biologicae,
Journal Year:
2023,
Volume and Issue:
15(1), P. 11423 - 11423
Published: March 16, 2023
The
present
work
was
carried
out
to
evaluate
the
phenolic
compounds
and
antioxidant
activities
of
some
solvent
extract
(methanol,
hydroethanol
aqueous)
several
Moroccan
medicinal
plants
known
for
their
high
properties.
extracts
were
obtained
by
sonication,
then,
total
phenolics
flavonoids
determined
using
Folin-Ciocalteu
Aluminium
chloride.
Afterwards,
Total
Antioxidant
Capacity
DPPH
scavenging
methods
performed.
Results
phytochemical
analysis
showed
that
content
highest
in
hydroethanolic
Arbutus
unedo
with
160.76
mg
GAE
g-1DM,
Inula
viscosa
489.77
QE
g-1
DM.
Also,
it
can
be
noted
unedo,
Argania
spinosa,
Myrtus
communis
exhibited
most
potent
activity
respectively
0.026;
0.043;
0.036
ml-1.
Natural Resources for Human Health,
Journal Year:
2024,
Volume and Issue:
4(4), P. 398 - 414
Published: Sept. 24, 2024
Research
on
cannabis
and
its
bioactive
derivatives,
including
cannabinoids,
non-cannabinoids,
extracts,
has
significantly
increased
in
recent
years
due
to
their
potential
therapeutic
applications
as
demonstrated
by
numerous
published
studies.
Although
there
is
evidence
of
the
efficacy
cannabinoid
non-cannabinoid
compounds
from
treatment
various
diseases
syndromes,
further
research
required
mitigate
damage
that
could
result
excessive
use
products,
particularly
tetrahydrocannabinol
(THC),
such
psychotropic
effects,
addiction,
cognitive
deficits,
cardiovascular
problems,
impacts
mental
health.
This
review
describes
phytochemical
biological
studies
grown
Morocco,
utilizing
databases
SciFinder,
ScienceDirect,
Scopus,
Google
Scholar,
PubMed
provide
updated
data
Morocco.
The
findings
this
aim
enable
investors,
economic
operators,
researchers,
policymakers
better
understand
current
state
thereby
promoting
industry
growth
cannabis-related
innovation.
Additionally,
paper
includes
a
brief
discussion
legalization
highlighting
new
opportunities
for
investment
medical
cannabis.
study
also
underscores
much
remains
be
explored
regarding
Moroccan
cannabis,
isolation
pre-clinical
clinical
trials
mass
production
approved
cannabis-based
medicines.
Furthermore,
are
intended
inform
key
stakeholders
about
fostering
Open Life Sciences,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Jan. 1, 2024
Moroccan
Cannabis
sativa
L.
seeds
were
investigated
for
their
phenolic
profile
and
antidiabetic
potential.
Ultra-high-performance
liquid
chromatography
with
diode
array
detection
electrospray
ionization
mass
spectrometry
analysis
revealed
a
rich
composition,
including
benzoic
acid,
cannabisin
B,
genistein,
epicatechin.
In
vitro,
the
seed
extract
exhibited
potent
α-amylase
inhibitory
activity
(half-maximal
concentration
=
25.02
±
4.03
μg/mL).
vivo
studies
in
diabetic
rats
demonstrated
significant
hypoglycemic,
hypolipidemic,
hepatoprotective,
nephroprotective
effects.
Molecular
docking
further
supported
these
findings,
revealing
strong
interactions
between
identified
enzyme.
These
results
highlight
potential
of
C.
as
natural
source
bioactive
compounds
diabetes
management.
