The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy DOI Creative Commons
Timothy R. McCulloch, Gustavo Rodrigues Rossi,

Socorro Miranda‐Hernandez

et al.

Immunology and Cell Biology, Journal Year: 2024, Volume and Issue: 102(8), P. 721 - 733

Published: June 14, 2024

Abstract Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, leading treatment option in cancer autoimmunity. In this study, we used murine model Salmonella Typhimurium infection investigate whether checkpoint could be applied bacterial infection. We found that T‐cell immunoglobulin ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, CD4 + T cells, drastically limiting their proinflammatory function. Blockade TIGIT vivo using monoclonal antibodies able enhance immunity improve clearance. The efficacy anti‐TIGIT dependent capacity antibody bind Fc (fragment crystallizable) receptors, giving important insights into mechanism therapy. This research suggests targeting such as TIGIT, has potential responses toward bacteria restore antibacterial options face resistance.

Language: Английский

The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy DOI Creative Commons
Timothy R. McCulloch, Gustavo Rodrigues Rossi,

Socorro Miranda‐Hernandez

et al.

Immunology and Cell Biology, Journal Year: 2024, Volume and Issue: 102(8), P. 721 - 733

Published: June 14, 2024

Abstract Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, leading treatment option in cancer autoimmunity. In this study, we used murine model Salmonella Typhimurium infection investigate whether checkpoint could be applied bacterial infection. We found that T‐cell immunoglobulin ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, CD4 + T cells, drastically limiting their proinflammatory function. Blockade TIGIT vivo using monoclonal antibodies able enhance immunity improve clearance. The efficacy anti‐TIGIT dependent capacity antibody bind Fc (fragment crystallizable) receptors, giving important insights into mechanism therapy. This research suggests targeting such as TIGIT, has potential responses toward bacteria restore antibacterial options face resistance.

Language: Английский

Citations

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